Prediction of drug release from ethylcellulose coated pellets

Muschert, Susanne; Siepmann, Florence; Leclercq, B.; Carlin, Brian; Siepmann, Juergen

doi:10.1016/j.jconrel.2008.12.003

Cited by 86 publications

(37 citation statements)

References 21 publications

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“…Nevertheless, the release of the active agent from delivery systems can be classified based on other mechanisms, such as, erosion (the product gradually dissolves in membrane shell), diffusion (the oil diffuses out of delivery system), extraction (mechanical forces during chewing or processing enlarge area of oil) and burst (a reservoir system ruptures under influence of mechanical or osmotic forces) [115]. Several diffusion models have been proposed in the literature to describe the release of an active agent from microcapsules [86,[116][117][118][119][120][121][122][123]. Table 5 presents a summary of the model release related to the diffusion of active agents through the polymeric membranes of microcapsules.…”

Section: Microcapsules Morphology and Release Mechanismsmentioning

confidence: 99%

Microencapsulation of essential oils with biodegradable polymeric carriers for cosmetic applications

Martins

Barreiro

Coelho

et al. 2014

Chemical Engineering Journal

287

167

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Microencapsulation provides an important tool for cosmetic and/or pharmaceutical industry, enabling protection and controlled release of several active agents. The encapsulation of essential oils in core-shell or matrix particles has been investigated for various reasons, e.g., protection from oxidative decomposition and evaporation, odor masking or merely to act as support to ensure controlled release. A large number of microencapsulation methods have been developed in order to be adapted to different types of active agents and shell materials, generating particles with a variable range of sizes, shell thicknesses and permeability, providing a tool to modulate the release rate of the active principle. With this work, an overview regarding properties and applications of essential oils and biodegradable polymers in the cosmetic field, focusing the use of polylactide as the base material to encapsulate thyme oil, as well as of microencapsulation processes with a particular emphasis on the coacervation, will be presented.2

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Section: Microcapsules Morphology and Release Mechanismsmentioning

confidence: 99%

Microencapsulation of essential oils with biodegradable polymeric carriers for cosmetic applications

Martins

Barreiro

Coelho

et al. 2014

Chemical Engineering Journal

287

167

View full text Add to dashboard Cite

show abstract

“…The osmolality of the gastrointestinal tract varies between 100 and 400 mOsm/kg (19). Muschert et al investigated different pellets containing various drugs under physiological (0.28-0.62 osmol/kg) conditions and concluded that the variation in the drug release rates from ethyl cellulose-coated pellets were only minor, irrespective of the type of the drug and pellet starter core (20,21).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar, and Microcrystalline Cellulose Inert Cores

et al. 2010

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Abstract. The objective of the present study was to investigate the effect of the pellet core materials isomalt, sugar, and microcrystalline cellulose on the in vitro drug release kinetics of coated sustainedrelease pellets as well as to evaluate the influence of different ratios of polymethacrylate copolymers exhibiting different permeability characteristics on the drug release rate. For characterization of the drug release process of pellets, the effect of osmolality was studied using glucose as an osmotically active agent in the dissolution medium. The pellet cores were layered with diclofenac sodium as model drug and coated with different ratios of Eudragit® RS30D and Eudragit® RL30D (ERS and ERL; 0:1 and 0.5:0.5 and 1:0 ratio) in a fluid bed apparatus. Physical characteristics such as mechanical strength, shape, and size proved that the inert cores were adequate for further processing. The in vitro dissolution tests were performed using a USP Apparatus I (basket method). The results demonstrated that, besides the ratio of the coating polymers (ERS/ERL), the release mechanism was also influenced by the type of starter core used. Sugar-and isomalt-type pellet cores demonstrated similar drug release profiles.

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“…In the second step alkali cellulose is further treated with ethyl chloride to yield raw EC. Similar to many cellulose derivatives, EC is a nontoxic, nonallergic, and nonirritant polymer characterized by an excellent film-forming ability (Muschert et al 2009). Among its many applications, EC can be used to encapsulate various drugs and/or chemicals through different techniques (Dow Chemical Company 1998).…”

Section: Introductionmentioning

confidence: 99%

Influence of key parameters on the morphology of ethylcellulose microcapsules prepared via room-temperature spray drying

Stefanescu

2010

Cellulose

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In this contribution, the morphology of ethylcellulose (EC) microspheres prepared with a room-temperature spray-drying technique is examined as a function of solution concentration, nozzle-totarget distance, and choice of solvent. Additionally, to determine the morphology of EC microspheres in the presence of an aqueous encapsulated material, a series of encapsulation measurements was conducted using hydrogen peroxide solution as the core component. It was observed that highly concentrated EC solutions lead to the formation of tail-like fibers adjacent to the sprayed microcapsules because of the high viscosity of solutions. Furthermore, when the solutions are sprayed from relatively short nozzle-to-target distances, porous EC films are formed on the target surface along with the EC microspheres. Three nozzle-to-target distances were tested (38, 69, and 115 cm), and the optimal one was found to be 115 cm. To determine how and to what extent the solvent used in room-temperature spraydrying experiments affects the morphology of resultant microspheres, EC was dissolved in either acetone or dichloromethane (DCM), and sprayed from the resultant solutions. While microcapsules prepared from the EC-in-DCM system exhibit even, but porous wall surfaces, microspheres prepared from the EC-in-acetone solution display irregular, but cavity-free wallsurfaces. Finally, as opposed to the pure EC capsules, the ones containing H 2 O 2 solution exhibit very smooth wall surfaces; this effect was attributed to the plasticizing effect that the aqueous solution has on the ethylcellulose macromolecules.

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Prediction of drug release from ethylcellulose coated pellets

Cited by 86 publications

References 21 publications

Microencapsulation of essential oils with biodegradable polymeric carriers for cosmetic applications

Microencapsulation of essential oils with biodegradable polymeric carriers for cosmetic applications

Evaluation of Drug Release From Coated Pellets Based on Isomalt, Sugar, and Microcrystalline Cellulose Inert Cores

Influence of key parameters on the morphology of ethylcellulose microcapsules prepared via room-temperature spray drying

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