Prediction of drug dissolution from Toremifene 80 mg tablets by NIR spectroscopy

Releasing fast and slow: Non-destructive prediction of density and drug release from SLS 3D printed tablets using NIR spectroscopy

“…Previous studies have highlighted the potential for non-destructive NIR spectroscopic methods to be able to predict the physical characteristics of tablets, including density and porosity ( Donoso et al, 2003 ; Otsuka, 2006 ), hardness ( Kandpal et al, 2017 ; Otsuka and Yamane, 2006 ; Qiushi et al, 2019 ) and drug release ( Ojala et al, 2020 ) due to the sensitivity to surface and internal structural effects. As an example, reflectance NIR spectroscopy has previously been used to quantify drug release in tablets manufactured at different compression levels ( Baranwal et al, 2019 ).…”

Artificial Intelligence-based Prediction of In Vitro Dissolution Profile of Immediate Release Tablets with Near-infrared and Raman Spectroscopy

“…In such a formulation, drug release rate is mainly determined by the concentration of the disintegrant in the tablet and the properties of the disintegrant such as particle size [29]. Earlier works have used NIR diffuse reflectance technique combined with PLS regression to predict the dissolution of formulations in which the dissolution rate was influenced by the amount of disintegrant [29][30][31]. However, Raman spectroscopy might have a better capability of measuring the concentration of the disintegrant in tablets, as compounds yield more distinct peaks when measured with this technique.…”

Prediction of dissolution profiles of sinomenine hydrochloride sustained-release tablets part I: using near-infrared spectra as predictors

“…Ojala et al used the design of experiments (DoE) approach to study the effects of variables systematically and substituted a conventional six-sample dissolution analysis of Toremifene 80 mg immediate release tablets by non-invasive NIR scanning of the production batches. 20 However, predicting dissolution profiles for sustained-release tablets can be very challenging due to their complex dissolution profiles.…”