Prediction of distant metastasis and survival in adenoid cystic carcinoma using quantitative 18 F-FDG PET/CT measurements

Lim, Weon Jeong; Oh, Jungsu S.; Roh, Jong–Lyel; Kim, Jae Seung; Kim, Soo-Jong; Choi, Seung‐Ho; Nam, Soon Yuhl; Kim, Sang Yoon

doi:10.1016/j.oraloncology.2017.12.013

Cited by 18 publications

(10 citation statements)

References 26 publications

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“…With its advent and development over the last decade, PET-CT has a unique advantage in the diagnosis of malignant tumors, especially in monitoring local progression and distant metastases [ 37 , 38 , 39 , 40 ]. The PET-CT approach involves the use of radionuclide labeling of compounds involved in human tissue metabolism, signal detection, and then image reconstruction [ 41 ].…”

Section: Clinical Symptom and Diagnosis Of Recurrent Npcmentioning

confidence: 99%

Treatment of Recurrent Nasopharyngeal Carcinoma: A Sequential Challenge

Peng

Wang

Fan

et al. 2022

Cancers

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Recurrent nasopharyngeal carcinoma (NPC), which occurs in 10–20% of patients with primary NPC after the initial treatment modality of intensity-modulated radiation therapy (IMRT), is one of the major causes of death among NPC patients. Patients with recurrent disease without distant metastases still have a chance to be saved, but re-treatment often carries more serious toxicities or higher risks. For this group of patients, both otolaryngologists and oncologists are committed to developing more appropriate treatment regimens that can prolong patient survival and improve survival therapy. Currently, there are no international guidelines for the treatment of patients with recurrent NPC. In this article, we summarize past publications on clinical research and mechanistic studies related to recurrent NPC, combined with the experience and lessons learned by our institutional multidisciplinary team in the treatment of recurrent NPC. We propose an objective protocol for the treatment of recurrent NPC.

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Section: Clinical Symptom and Diagnosis Of Recurrent Npcmentioning

confidence: 99%

Treatment of Recurrent Nasopharyngeal Carcinoma: A Sequential Challenge

Peng

Wang

Fan

et al. 2022

Cancers

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“…Notably, the twenty-year survival rate is only 20%, due to high incidences of recurrence and metastasis [5]. The lungs constitute the most common site for metastases, while perineural invasion is characteristic of local progression in ACC [6][7][8]. Distant metastasis is the most common type of relapse, with about 30% of patients with distant metastasis not experiencing recurrence of the primary lesion [9,10].…”

Section: Introductionmentioning

confidence: 99%

Targeted Therapy, Chemotherapy, Immunotherapy and Novel Treatment Options for Different Subtypes of Salivary Gland Cancer

Müller

Haderlein

Lettmaier

et al. 2022

JCM

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Surgical resection remains the first line treatment for salivary gland cancer (SGC). In the case of locally advanced disease, surgery is followed by adjuvant radiotherapy. Surgical resection should be favored in resectable locoregional recurrent disease as well, and even the complete resection of all distant oligometastases has clinical benefit for the patients. For inoperable and disseminated metastatic disease, a multitude of systemic therapies including chemotherapy, targeted therapy, and immunotherapy are available. In this review, the current therapeutic options for inoperable recurrent or metastatic SGCs are summarized. Systemic treatment can achieve prolonged progression-free and overall survival, while the overall prognosis remains poor. Current clinical trials include only a limited number of patients and mostly combine different histologic subtypes. Additionally, no randomized controlled trial comparing different therapeutic options has been performed. In the future, further studies with a larger patient cohort and ideally only one histologic subtype are needed in order to improve the outcome for SGC patients. However, this may be difficult to accomplish due to the rarity and diversity of the disease. Additionally, molecular analyses need to be performed routinely in order to individualize treatment and to go one step further towards precision medicine.

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“…However, none of these authors analysed the possible risk factors of DM. Although a number of clinical pathologic variables, including tumour stage, neck lymph node stage, disease stage and disease histology, have been reported to be associated with DM in salivary adenoid cystic carcinoma [15–17], whether there are similar phenomena in parotid AciCC remains unknown. Therefore, the current study aimed to evaluate the predictors of DM in parotid AciCC.…”

Section: Introductionmentioning

confidence: 99%

Predictors of distant metastasis in parotid acinic cell carcinoma

Fang

et al. 2019

BMC Cancer

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Background Distant metastasis (DM) is a common treatment failure pattern in acinic cell carcinoma (AciCC) of the major salivary glands; therefore, the main goal of this study was to analyse the predictors of DM in parotid AciCC. Methods Consecutive patients with surgically treated parotid AciCC who were followed for at least 5 years were retrospectively reviewed. Data regarding age, sex, TNM stage, pathologic characteristics, surgical treatment, and follow-up examinations were collected and analysed. The primary end-point was DM control (DMC); the DMC survival was calculated from the date of surgery to the date of event or the latest follow-up examination and analysed by the Kaplan-Meier method. Independent prognostic factors were evaluated by the Cox proportional hazards method. Results A total of 144 patients were included. Positive intraparotid nodes (IPNs) were noted in 34 (31.8%) patients. High-grade transformation was noted in 12 (8.3%) patients. A total of 83 (57.6%) patients underwent neck dissection, and neck node metastasis was proven in 37 (44.6%, 37/83) patients. The 10-year DMC rate was 86%. The Cox model analysis confirmed IPN metastasis (1.854 [1.061–4.144], p = 0.011) and high-grade transformation (4.219 [1.948–15.553], p < 0.001) as independent predictive factors of the DMC survival. Conclusion IPN metastasis and high-grade transformation are independent prognostic factors of the DMC survival.

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Prediction of distant metastasis and survival in adenoid cystic carcinoma using quantitative 18 F-FDG PET/CT measurements

Cited by 18 publications

References 26 publications

Treatment of Recurrent Nasopharyngeal Carcinoma: A Sequential Challenge

Treatment of Recurrent Nasopharyngeal Carcinoma: A Sequential Challenge

Targeted Therapy, Chemotherapy, Immunotherapy and Novel Treatment Options for Different Subtypes of Salivary Gland Cancer

Predictors of distant metastasis in parotid acinic cell carcinoma

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