Prediction of different ovarian responses using anti-Müllerian hormone following a long agonist treatment protocol for IVF

Heidar, Zahra; Bakhtiyari, Mahmood; Mirzamoradi, Masoumeh; Zadehmodarres, Shahrzad; Sarfjoo, Fatemeh Sadat; Mansournia, Mohammad Ali

doi:10.1007/s40618-015-0297-4

Cited by 22 publications

(11 citation statements)

References 33 publications

(36 reference statements)

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“…When analyzing IVF results published by Human Fertilization and Embryology Authority (HFEA), the live birth rate for the age range 40–42 was 12.7, 5.1 % for ages 43–44, and 1.5 % for women aged 45 and older [ 62 ]. It is well established that the success of IVF procedures depends on many factors among which the most important and independent ones are: age and serum AMH concentration [ 63 – 66 ]. AMH can strongly predict poor response in the controlled ovarian stimulation.…”

Section: Amh As An Indicator Of Fertility In Late Reproductive Age Womentioning

confidence: 99%

Fertility in women of late reproductive age: the role of serum anti-Müllerian hormone (AMH) levels in its assessment

Męczekalski

Czyźyk

Kunicki³

et al. 2016

J Endocrinol Invest

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IntroductionFertility is referred to the capability for having offspring and can be evaluated by fertility rate. Women’s fertility is strictly dependent on individual’s age. The fertility peak occurs in the early 20s, and it starts to decline in the third and fourth decades of life (falling sharply after age 35).AimThe aim of this work is to review the available data concerning fertility in women of late reproductive age, especially the role of serum anti-Müllerian hormone (AMH) levels.Results There are a lot of factors responsible for decrease of fertility in women of late reproductive age. These factors can be classified as oocyte-dependent (decrease in oocyte quantity and quality) and oocyte-independent (reproductive organs [uterus, oviducts] status and general health). Anti-Müllerian hormone (AMH) is a dimeric glycoprotein of the transforming growth factor-β (TGF-β) superfamily produced directly by the ovarian granulosa cells of secondary, preantral, and early antral follicles. It has been used as an ovarian reserve marker since 2002. Anti-Müllerian hormone seems to be the best endocrine marker for assessing the age-related decline of the ovarian pool in healthy women. Evaluation of AMH’s predictive value in the naturally aging population is important for counseling women about reproductive planning as well as for treatment planning for women experiencing hormone-sensitive gynecological conditions such as endometriosis and fibroids.Conclusions AMH can be considered as an indicator of fertility in late reproductive age women and pregnancy outcome in assisted reproductive technology cycles. AMH can strongly predict poor response in the controlled ovarian stimulation.

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Section: Amh As An Indicator Of Fertility In Late Reproductive Age Womentioning

confidence: 99%

Fertility in women of late reproductive age: the role of serum anti-Müllerian hormone (AMH) levels in its assessment

Męczekalski

Czyźyk

Kunicki³

et al. 2016

J Endocrinol Invest

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“…Compared with recent studies (Hamdine et al, 2015;Heidar et al, 2015;Nardo et al, 2009;Polyzos et al, 2013), the AMH cut-off value predicting high and normal ovarian response in the current study (2.6 ng/ml) is lower (Hamdine et al, 2015: 4.5 ng/ml; Heidar et al, 2015: 3.4 ng/ml;Nardo et al, 2009: 3.75 ng/ml; Polyzos et al, 2013: 3.52 ng/ml), which suggests that the utilization of AMH for high ovarian response should be tailored for the Chinese population. On the other hand, the AMH cutoff value predicting low and normal ovarian response (1.1 ng/ml) was similar to previous studies (Hamdine et al, 2015: 0.8 ng/ml; Heidar et al, 2015: 1.2 ng/ml; Nardo et al, 2009: 1.0 ng/ml; Polyzos et al, 2013: 1.37 ng/ml). Additionally, Ficicioglu et al (2014) suggested that AMH cut-off values ≤1 ng/ml may be appropriate for low ovarian response prediction.…”

Section: Analysis Variablesmentioning

confidence: 88%

“…ROC curve analyses indicated that Day 3 AMH concentration had the highest sensitivity and specificity values, and the AMH curve had the highest AUC (0.92) followed by the AUC for antral follicles (0.78) and then for age (AUC = 0.63). Recent studies also proved the superior prediction value of AMH among different markers of ovarian reserve and response to stimulation (Brodin et al, 2015;Heidar et al, 2015;Salmassi et al, 2015). This study further confirmed the AMH predictive value in a Chinese clinical setting.…”

Section: Analysis Variablesmentioning

confidence: 97%

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Anti-Müllerian hormone for prediction of ovarian response in Chinese infertile women undergoing IVF/ICSI cycles: a prospective, multi-centre, observational study

Gong

Zhu

et al. 2016

Reproductive BioMedicine Online

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This study explored the correlation between serum anti-Müllerian hormone (AMH) concentration and the number of retrieved oocytes after ovarian stimulation in Chinese infertile women undergoing assisted reproductive technology treatment and AMH cut-off values predicting low and high ovarian response. This was a prospective, multi-centre, observational study. A total of 615 subjects were included in nine assisted reproductive centres in China for outcome analysis. Subjects received assisted reproductive technology treatment and used recombinant human FSH (r-HFSH) or r-HFSH plus recombinant LH (rLH) for ovarian stimulation according to conventional treatment regimens. The main outcome variables were correlations between AMH and the number of retrieved oocytes and the cut-off values of AMH predicting low and high ovarian response. Serum AMH concentration was positively correlated with the number of oocytes retrieved in Chinese infertile women treated with IVF/intracytoplasmic sperm injection (ICSI) (Pearson correlation coefficient = 0.4754, P < 0.0001). The optimal AMH cut-off value was 2.6 ng/ml (sensitivity: 81.28%, specificity: 59.51%) in predicting high and normal response, and 1.1 ng/ml (sensitivity: 52.27%, specificity: 87.23%) in predicting low and normal response. In conclusion, serum AMH concentration can be used as a biomarker to predict ovarian response in Chinese infertile women treated with assisted reproductive technology.

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“…In any case, regardless of the debate in literature, it is certain that the two main factors that influence the success of ART procedures are age and AMH levels (75,(83)(84)(85) but no AMH value cut-off was identified under which pregnancy was excluded and many different studies have obtained pregnancy with ART in women with very low AMH concentration levels (80,(86)(87)(88). In conclusion AMH can strongly predict poor ovarian response in ovarian stimulation (89) and it is a useful tool to schedule fertility treatments, but it has little power in predicting pregnancy rate.…”

Section: Amh and Artmentioning

confidence: 99%

Anti-Müllerian hormone: clinical implications in Gynecological Endocrinology. An update review

et al. 2020

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Anti-Müllerian hormone (AMH) is produced by the granulosa cells of the ovary with serum levels that grow until puberty, remain stable up to 30 years and then begin to decline until menopause. It is mainly produced by pre-and early antral follicles with an average diameter of 5-8 mm and it indirectly represents the ovarian reserve (OR). The purpose of this review is to identify what can currently be done with AMH, according to the most recent scientific evidence. AMH does not appear to be a marker for fertility as it does reflect the quantity but not the quality of follicles. It is not able to predict the spontaneous onset of pregnancy, nor the pregnancy rate in cycles of assisted reproduction technology (ART) but is a good predictor of ovarian response to hyperstimulation and it is useful in planning a couple's fertility treatment even in the case of women undergoing chemotherapy, radiotherapy and ovarian surgery. It helps to identify women suffering from mild forms of polycystic ovary syndrome (PCOS) and diagnose and manage menopause and premature ovarian failure (POF). Finally, AMH levels may be used in case of granulosa cells tumors, both for diagnosis and follow up after surgery.

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Prediction of different ovarian responses using anti-Müllerian hormone following a long agonist treatment protocol for IVF

Abstract: By considering the age of the patient undergoing infertility treatment as a variable affecting ovulation, use of AMH levels showed to be a good test to discriminate between different ovarian responses.

Cited by 22 publications

References 33 publications

Fertility in women of late reproductive age: the role of serum anti-Müllerian hormone (AMH) levels in its assessment

Fertility in women of late reproductive age: the role of serum anti-Müllerian hormone (AMH) levels in its assessment

Anti-Müllerian hormone for prediction of ovarian response in Chinese infertile women undergoing IVF/ICSI cycles: a prospective, multi-centre, observational study

Anti-Müllerian hormone: clinical implications in Gynecological Endocrinology. An update review

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