Prediction of Diabetic Nephropathy from the Relationship between Fatigue, Sleep and Quality of Life

Abstract

Fatigue and poor sleep quality are the most common clinical complaints of people with diabetes mellitus (DM). These complaints are early signs of DM and are closely related to diabetic control and the presence of complications, which lead to a decline in the quality of life. Therefore, an accurate measurement of the relationship between fatigue, sleep status, and the complication of DM nephropathy could lead to a specific definition of fatigue and an appropriate medical treatment. This study recruited 307 people with Type 2 diabetes from two medical centers in Northern Taiwan through a questionnaire survey and a retrospective investigation of medical records. In an attempt to identify the related factors and accurately predict diabetic nephropathy, we applied hybrid research methods, integrated biostatistics, and feature selection methods in data mining and machine learning to compare and verify the results. Consequently, the results demonstrated that patients with diabetic nephropathy have a higher fatigue level and Charlson comorbidity index (CCI) score than without neuropathy, the presence of neuropathy leads to poor sleep quality, lower quality of life, and poor metabolism. Furthermore, by considering feature selection in selecting representative features or variables, we achieved consistence results with a support vector machine (SVM) classifier and merely ten representative factors and a prediction accuracy as high as 74% in predicting the presence of diabetic nephropathy.

Deteriorated sleep quality and associate factors in patients with type 2 diabetes mellitus complicated with diabetic peripheral neuropathy

“…Besides, the participants of this study were patients with T2DM who suffered DPN. The occurrence of complications of diabetes is not conducive to ensuring sleep quality ( Lien et al, 2020 ), which may be the reason for the higher prevalence of poor sleep quality in this study.…”

“…DPN is a major cause of physical disability in diabetic patients which can occur at all stages of diabetes development. Diabetic patients often experience poor sleep quality, while those with DPN may have even worse sleep quality ( Lien et al, 2020 ). In this study, the sleep quality and influencing factors were analyzed and nomogram prediction model in patients with T2DM who suffered DPN was constructed.…”