Prediction of diabetic foot ulcer healing in type 2 diabetic subjects using routine clinical and laboratory parameters

Alrasheedi, Ibrahim M; Basheir, Osman H; Haider, Khawaja Husnain

doi:10.2147/rred.s98506

Cited by 9 publications

(19 citation statements)

References 12 publications

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“…21 Likewise, HbA1c wellknown marker of detecting glycaemic control for last 2 to 3 months, have gained importance and have been comprehensively investigated in relation with diabetic foot ulcers, gangrene, and limb amputation. 22 There are several conflicting reports about amputation risk and HbA1c levels in literature. Nerone et al, detected that major amputations was not affected to elevated HbA1c levels.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, in another study it was claimed that lower serum albumin levels show also poor prognosis and associated with increased amputation risk 21 . Likewise, HbA1c well‐known marker of detecting glycaemic control for last 2 to 3 months, have gained importance and have been comprehensively investigated in relation with diabetic foot ulcers, gangrene, and limb amputation 22 . There are several conflicting reports about amputation risk and HbA1c levels in literature.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot

Gülcü

Etli

Karahan

et al. 2020

International Wound Journal

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Diabetic foot is challenging progressive disease which requires multisystemic control. Neuropathy, arteriopathy, and cellular responses should treated collaboratively. Despite all medical advances, diabetic foot can highly resulted with amputation and also re‐amputation can be required because of failed wound healing. In this study, we aimed to investigate the relation between blood parameters and amputation events. Diabetic 323 patients include to the study who referred to orthopaedic clinic for amputation. Amputation levels (amputation levels phalanx, metatarsal, lisfranc, syme, below knee, knee‐disarticulation, above‐knee amputation) and re‐amputations recorded and compared with routine blood parameters. Re‐amputation was observed at 69 patients. The significant difference detected between lower albumin, higher HbA1c, higher CRP levels (P < 0.05) in regards to gross amputation levels, and increased wound depth. Furthermore, lower albumin levels and higher levels of WBC, HbA1c, CRP, and Creatinine were detected in re‐amputation levels. Especially, HbA1c, CRP, and Creatinine levels were found as upper bound of reference line for re‐amputation. The statistically optimal HbA1c cutoff point for diabetes was ≥7.05%, with a sensitivity of 86% and a specificity of 59%. In according to our results, simple blood parameters can be useful for observing the progress of amputation in diabetic foot. Particularly, lower albumin, and higher HbA1c, CRP, and Creatinine levels detected as related with poor prognosis. Besides, screening of HbA1c level seems to be highly sensitive for detecting of re‐amputation possibility.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot

Gülcü

Etli

Karahan

et al. 2020

International Wound Journal

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“…Thus, these factors should be critically considered while treating gangrene patients. As per a prospective analytical study conducted by AlGoblan et al, 25 early resolution of the foot ulcers occurred in 61% patients who were a normal weight, compared to 49% obese patients whose condition took more than double the time to resolve. 26 …”

Section: Pathophysiological Factors In Dry Gangrenementioning

confidence: 85%

Autoamputation of diabetic toe with dry gangrene: a myth or a fact?

Wahbi¹

2018

DMSO

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Diabetes is associated with various complications and reduced quality of life. Of the many complications, some are life-threatening. Among these, foot complications remain an important concern. The major foot complications include foot ulceration, cellulitis, abscess, wet gangrene, dry gangrene, and necrotizing fasciitis, with different pathophysiological concepts behind each of them. Gangrene occurs due to reduced blood supply in the body tissues that leads to necrosis. This condition may arise because of an injury, infection, or other health conditions, majorly diabetes. Gangrene is classified as dry, wet, and gas gangrene. In case of wet and gas gangrene, surgical amputation is usually performed to prevent the spread of infection to other tissues. In dry gangrene, due to the presence of clear demarcation, autoamputation is preferred in certain parts of the globe. The present review aims to analyze the mode of dry gangrene management in diabetic patients based on previous evidence and plans to highlight various management strategies available for dry gangrene and the advantages/disadvantages of different treatments with special consideration to autoamputation.

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“…[9,10,11,13,14,15,16,20,21,22,23,24,25,26,27] Results of studies designed to assess the risk of LEA in CLI patients following bypass surgery have also been reported previously. [13,14,15,21,22,23,24,25] Findings of the present study are consistent with several of these previous studies that also identified that WBC, PLR levels, and RC at hospital admission were important risk factors for LEA. [10,13,14]…”

Section: Discussionmentioning

confidence: 99%

Risk stratification for low extremity amputation in critical limb ischemia patients who have undergone endovascular revascularization

et al. 2019

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Prediction of diabetic foot ulcer healing in type 2 diabetic subjects using routine clinical and laboratory parameters

Cited by 9 publications

References 12 publications

Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot

Analysis of routine blood markers for predicting amputation/re‐amputation risk in diabetic foot

Autoamputation of diabetic toe with dry gangrene: a myth or a fact?

Risk stratification for low extremity amputation in critical limb ischemia patients who have undergone endovascular revascularization

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