Prediction of Deleterious Single Amino Acid Polymorphisms with a
Consensus Holdout Sampler
Óscar Álvarez-Machancoses,
Eshel Faraggi,
Enrique J. deAndrés-Galiana
et al.
Abstract:Background:
Single Amino Acid Polymorphisms (SAPs) or nonsynonymous Single Nucleotide
Variants (nsSNVs) are the most common genetic variations. They result from missense
mutations where a single base pair substitution changes the genetic code in such a way that the triplet
of bases (codon) at a given position is coding a different amino acid. Since genetic mutations
sometimes cause genetic diseases, it is important to comprehend and foresee which variations are
harmful and which ones are neutral (not causing c… Show more
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