Prediction of delayed neck metastasis in patients with stage I/II squamous cell carcinoma of the tongue

Abstract

Such factors provide useful information with regard to DNM and the prognosis. We concluded that patients with early SCC whose tumors are > 4 mm in thickness and immunopositive for Flt-4 are particularly at risk of developing DNM.

A meta-analysis of the randomized controlled trials on elective neck dissection versus therapeutic neck dissection in oral cavity cancers with clinically node-negative neck

“…This is similar to the findings from all the randomized controlled trials in this meta-analysis (Table 4) The depth or thickness of the primary tumor has been shown to be an important factor in neck metastasis, if the tumor depth exceeds 4mm, the risk of developing occult metastasis in the neck is increased to between 38 -70% [8,84,105]. Tumor thickness is therefore an important pathologic factor to identify the patients at greater risk of developing neck node metastasis.…”

“…This value was a little bit higher than what other studies have reported [8,84,105]. The same study also showed a survival rate of 81% in patients with tumor depth of less than 4mm as compared to 43% for those with tumor depth greater than 4mm [46].…”

Importancia de la detección temprana de cáncer.

“…El hallazgo de cáncer en los ganglios es el factor de riesgo para recurrencia, ya que disminuye la sobrevida de 50% a 15-30% en un periodo de 5 años (6). Varios estudios coinciden en que el hallazgo de cáncer en los ganglios regionales es el factor de riesgo para recurrencia (3)(4)(5)(6). Una serie grande publicada por Lam, con más de 600 sujetos con diagnóstico de cáncer de lengua, acumulados en 24 años, muestra que factores como: la presencia de ganglios cervicales comprometidos, la localización del cáncer en la base de la lengua y la edad avanzada, están relacionados con una menor tasa de sobrevida.…”

Polymorphisms of microRNA-Binding Sites in Integrin Genes Are Associated with Oral Squamous Cell Carcinoma Susceptibility and Progression

“…OSCC is characterized by low survival rate and high morbidity (Funk et al 2002;Okamoto et al 2002). The 5-year survival rate of OSCC is slightly above 50%, which is in part due to the lack of effective biomarkers for both early diagnosis and optimal treatment (Weinberg and Estefan 2002).…”