The majority of existing findings regarding expansion risks in concretes containing waste glass stem from experimental studies. There is a need for rapid assessment methods to ensure safer recycling of glass waste in cementitious composites. In this study, an artificial neural network (ANN) model was developed to accurately predict ASR expansion/mitigation resulting from the integration of glass waste in mortars. The analysis considered glass incorporation either separately as waste glass powder (WGP) and waste glass aggregates (WGA), or in combination, at contents of up to 100% for WGA and 30% for WGP. A set of 175 mixtures was analyzed, considering five distinct variables, which encompassed different mix proportions, involving varying components of cement, natural aggregates, WGP, and WGA, in addition to the duration of environmental exposure. The results show that the expansion of WGA-mortars decreased with the increased incorporation of WGP. The expansion values obtained from validation and experience confirm the high accuracy of the developed ANN model, with validation coefficients reaching up to 98.061% and small value of t squared error (MSE).