Prediction of coronary heart disease or heart failure using high‐sensitivity cardiac troponin T: A pilot study

Árnadóttir, Ásthildur; Vestergaard, Kirstine Roll; Sölétormos, György; Steffensen, Rolf; Goetze, Jens P.; Iversen, Kasper

doi:10.1111/eci.13009

Cited by 8 publications

(5 citation statements)

References 23 publications

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“…Elevated troponin values suggest myocardial damage, which can be seen in acute myocardial infarction, unstable angina, pulmonary infarction, and heart failure. Our findings are consistent with those of a pilot study 31 and a cohort study 32 reporting hs-TnT as a good prognostic marker for mortality. Moreover, hs-TnT can be used to detect subclinical cardiac disease.…”

Section: Discussionsupporting

confidence: 92%

Clinical outcomes and survival analysis in patients with psycho-cardiological disease: a retrospective analysis of 132 cases

et al. 2021

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Objectives The deleterious effects of psychological problems on coronary heart disease (CHD) are not satisfactorily explained. We explored influential factors associated with mortality in psycho-cardiological disease in a Chinese sample. Methods Of 7460 cardiac patients, we selected 132 patients with CHD and mental illness. Follow-up was conducted via telephone. We analyzed clinical characteristics, clinical outcomes, and survival. Results The clinical detection rate of psycho-cardiological disease in the overall patient population was 1.8%. Of these, 113 patients completed follow-up; 18 died owing to cardiovascular diseases during follow-up. Kaplan–Meier analysis showed dysphagia, limb function, self-care ability, percutaneous coronary intervention, low-density lipoprotein, total cholesterol, pro-brain natriuretic peptide and high-sensitivity (hs) troponin T had significant associations with cumulative survival. Cox regression analysis showed total cholesterol (hazard ratio [HR]: 2.765, 95% confidence interval [CI]: 1.001–7.641), hs troponin T (HR: 4.668, 95% CI: 1.293–16.854), and percutaneous coronary intervention (HR: 3.619, 95% CI: 1.383–9.474) were independently associated with cumulative survival. Conclusions The clinical detection rate of psycho-cardiological disease was far lower than expected. Normal total cholesterol and hs troponin T were associated with reduced cardiovascular disease mortality over 2 years. Percutaneous coronary intervention is a prognostic risk factor in patients with psycho-cardiological disease.

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Section: Discussionsupporting

confidence: 92%

Clinical outcomes and survival analysis in patients with psycho-cardiological disease: a retrospective analysis of 132 cases

et al. 2021

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“…It was found that the patients in observation group had obviously lower LVESV, LVEDV, and LVEF than the Ctrl (P < 0.05), and LVESD, LVEDD, CO, and CI were obviously higher (P < 0.05). LVESV, LVEDV, LVEF, LVESD, LVEDD, CO, and CI indicators are important indicators used to evaluate the volume, shape, function, and structure of the heart [20]. It was found that Shexiang Baoxin pills could reduce the left ventricular volume, increase the left ventricular inner diameter, and improve the heart function by increasing cardiac output and enhancing cardiac systolic function.…”

Section: Discussionmentioning

confidence: 99%

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

Gao

Wang

et al. 2021

Journal of Healthcare Engineering

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This paper was aimed to explore the application of the block matching pyramid (BMP) algorithm in echocardiographic spot tracking in patients with coronary heart disease (CHD) and angina pectoris, as well as the effect of Shexiang Baoxin pills (a kind of drug containing musk, which is good for cardiac diseases) on blood lipids, cardiac function, and curative effect. 206 patients with CHD angina pectoris in the hospital from July 2018 to May 2020 were selected as the research subjects and were enrolled into the control (Ctrl) group (conventional treatment, n = 103) and the observation group (the Shexiang Baoxin pill was given on the basis of conventional treatment, n = 103) in random. Then, the patients’ echocardiograms were obtained, and the BMP algorithm was used to track the echocardiograms. At 12 months after treatment, the total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were compared. Besides, the differences between left ventricular end-systolic volume (LVESV), left ventricular end-systolic diameter (LVESD), left ventricular end-diastolic volume (LVEDV), left ventricular end-diastolic dimension (LVEDD), cardiac index (CI), cardiac output (CO), and LVEF were observed. Finally, the efficacy of angina pectoris and electrocardiogram was calculated. It was found that the BMP algorithm can track the echocardiograms and display the movement and displacement of the patients’ left ventricle. After treatment, in contrast with the Ctrl, the levels of TC, TG, and LDL-C in the observation group were obviously lower ( P < 0.05 ); the LVESV, LVEDV, and LVEF were obviously lower ( P < 0.05 ), the LVESD, LVEDD, CO, and CI were obviously higher ( P < 0.05 ), the total score of angina after treatment was obviously lower ( P < 0.05 ), and the total effective rates of angina pectoris and echocardiogram were obviously higher ( P < 0.05 ). In conclusion, echocardiographic spot tracking can realize the diagnosis of patients with CHD angina pectoris, and Shexiang Baoxin pill can regulate the blood lipid level and improve the echocardiographic indicators and the clinical efficacy is obvious.

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“…The characteristics of troponin C isoform existing in both cardiac and skeletal muscle makes it not be considered as a sensitive marker of cardiac injury. However, the myocardium speci c troponin I and T is an useful biomarker for myocardial necrosis and has been clinically used for early diagnosis and prognosis in patients with cardiopulmonary diseases such as acute coronary syndrome, acute myocardial infarction, heart failure and pulmonary embolism [20][21][22][23][24][25][26][27]. Whereas the clinical use of cardiac troponin could not only be limited in primary cardiopulmonary diseases.…”

Section: Discussionmentioning

confidence: 99%

The prognostic value of cardiac troponin T in different age groups of traumatic brain injury patients

Wang

2021

Acta Neurol Belg

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BackgroundThe cardiac dysfunction has been con rmed as a common non-neurological complication and associated with increased mortality in traumatic brain injury (TBI) patients. As a biological marker of cardiac injury, the cardiac troponin T (TnT) has been veri ed correlated with outcome of some nontraumatic brain injury patients. However, the prognostic value of TnT in TBI patients has not been clearly illustrated. We designed this study to explore the association between TnT and outcome of TBI patients in different age subgroups. MethodsPatients diagnosed with TBI in a prospective critical care database were eligible for this study. Univariate logistic regression analysis was rstly performed to explore the relationship between included variables and mortality. Then, the real effect of TnT on outcome of different age subgroups was analyzed by multivariate logistic regression analysis adjusting the confounding effects of other signi cant risk factors. Finally, we draw receiver operating characteristic (ROC) curves to evaluate the prognostic value of TnT in different age groups of TBI patients.Results 520 patients were included in this study with mortality rate of 20.2%. There were 112 (21.5%) non-elderly patients (age < 65) and 408 (78.5%) elderly patients (age ≥ 65). Non-survivors had higher percentage of previous acute myocardial infarction (p = 0.019) and pupil no-reaction (p = 0.028; p = 0.011) than survivors. Survivors had higher GCS (p < 0.001) and lower TnT than non-survivors (p < 0.001). TnT was signi cantly associated with mortality in non-elderly patients (p = 0.031) but not in overall patients (p = 0.143) and elderly patients (p = 0.456) in multivariate logistic regression analysis. The AUC (area under the ROC curve) value of TnT in overall, non-elderly and elderly patients was 0.644, 0.693 and 0.632, respectively. Combining TnT with GCS increased the sensitivity of predicting mortality of both non-elderly and elderly TBI patients. ConclusionThe prognostic value of TnT differed between elderly and non-elderly TBI patients. Level of TnT was associated with mortality of non-elderly TBI patients but not elderly patients. Combining the TnT with GCS could increase the sensitivity of prognosis evaluation.

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Prediction of coronary heart disease or heart failure using high‐sensitivity cardiac troponin T: A pilot study

Cited by 8 publications

References 23 publications

Clinical outcomes and survival analysis in patients with psycho-cardiological disease: a retrospective analysis of 132 cases

Clinical outcomes and survival analysis in patients with psycho-cardiological disease: a retrospective analysis of 132 cases

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

The prognostic value of cardiac troponin T in different age groups of traumatic brain injury patients

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