Prediction of Coronary Artery Disease Severity Using CHADS2 and CHA2DS2-VASc Scores and a Newly Defined CHA2DS2-VASc-HS Score

Çetın, Mustafa; Cakici, Musa; Zencir, Cemil; Taşolar, Hakan; Baysal, Erkan; Ballı, Mehmet; Aktürk, Erdal

doi:10.1016/j.amjcard.2013.11.056

Cited by 93 publications

(113 citation statements)

References 24 publications

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“…Recently, Cetin et al [7] reported that the CHADS 2 , CHA 2 DS 2 -VASc, and newly defined CHA 2 DS 2 -VASc-HS scores could predict CAD severity using the Gensini score in patients who underwent diagnostic coronary angiography [7]. The CHA 2 DS 2 -VASc-HSF score was formulated [heart failure (signs/symptoms of heart failure confirmed with objective evidence of cardiac dysfunction), hypertension (HT) (defined as measurements of systolic and diastolic blood pressure ≥ 140/90 mm Hg or taking antihypertensive medications), age, diabetes mellitus (DM) (defined as a fasting blood glucose level > 126 mg/dL or blood glucose ≥ 200 mg/dL or using antidiabetic drugs), previous ischaemic stroke or transient ischaemic attack (TIA), vascular disease (defined as myocardial infarction [MI] and peripheral artery disease including prior revascularisation, amputation or angiographic evidence or aortic plaque), male sex, hyperlipidaemia (defined as increased level of low density lipoprotein cholesterol (LDL-C) according to the National Cholesterol Education Program-3 recommendations and history of using lipid lowering medications), smoking status (defined as smoking > 10 cigarettes a day for at least one year without a quit attempt), and family history of CAD (defined as MI before 55 years of age for men or 65 years of age for women in first-degree relatives)] (Table 1).…”

Section: Introductionmentioning

confidence: 99%

Predictive value of newly defined CHA2DS2-VASc-HSF score for severity of coronary artery disease in ST segment elevation myocardial infarction

et al. 2016

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A b s t r a c tBackground: CHADS 2 and CHA 2 DS 2 -VASc scores are widely used in clinical practice and include similar risk factors for the development of coronary artery disease (CAD). It is known that the factors comprising the newly defined CHA 2 DS 2 -VASc-HSF score promote atherosclerosis and are associated with severity of CAD. Aim:To investigate the association of the CHA 2 DS 2 -VASc-HSF score with the severity of CAD as assessed by SYNTAX score (SxS) in patients with ST segment elevation myocardial infarction (STEMI).Methods: A total of 454 consecutive patients with STEMI (males 79%, mean age 57.3 ± 12.9 years), who underwent primary percutaneous coronary intervention were included in our study. The patients were divided into three groups according to the SxS tertiles: low SxS group (SxS < 14; 151 patients), intermediate SxS group (SxS 14-20; 152 patients), and high SxS group (SxS ≥ 21; 151 patients). Results:The CHADS 2 , CHA 2 DS 2 -VASc, and CHA 2 DS 2 VASc-HSF scores were found to be significantly different among the SxS groups (p < 0.001, p < 0.001, and p < 0.001). After multivariate analysis, the CHA 2 DS 2 -VASc-HSF score was associated with high SxS (odds ratio [OR] 1.258, 95% confidence interval [CI] 1.026-1.544; p = 0.028) together with age (OR 1.032, 95% CI 1.013-1.050; p = 0.001) and ejection fraction (OR 0.927, 95% CI 0.901-0.955; p < 0.001). Conclusions:A newly diagnosed CHA 2 DS 2 -VASc-HSF score predicts the severity of atherosclerosis in patients with STEMI.

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Section: Introductionmentioning

confidence: 99%

Predictive value of newly defined CHA2DS2-VASc-HSF score for severity of coronary artery disease in ST segment elevation myocardial infarction

et al. 2016

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“…15 In addition, potential clinical use of CHA 2 DS 2 -VASc score in patients with HF and coronary artery disease (CAD) has been shown. 16,17 Several reports suggest that there is a close association between components of the CHA 2 DS 2 -VASc score and risk of VTE. [18][19][20][21][22][23][24][25] From this point of view, we speculated the hypothesis that higher CHA 2 DS 2 -VASc scores might be associated with risk of mortality in patients with APE.…”

Section: Introductionmentioning

confidence: 99%

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

Onuk

Karataş

İpek

et al. 2016

Clin Appl Thromb Hemost

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Background: CHA 2 DS 2 -VASc score has been validated in risk prediction for stroke and thromboembolism in patients with atrial fibrillation (AF). Association of CHA 2 DS 2 -VASc score with higher risk of venous thromboembolism and pulmonary embolism (PE) has also been shown. In this study, we investigated the long-term prognostic value of CHA 2 DS 2 -VASc score in patients with acute pulmonary embolism (APE). Methods: Consecutive patients with APE presenting to our emergency department were retrospectively recruited. Patients with AF and who died secondary to causes other than PE were excluded from the study. The CHA 2 DS 2 -VASc score and pulmonary embolism severity index (PESI) were calculated. Results: Two hundred seventy seven participants were included in the study. The mortality rate was 18.7%. Twenty-two cases died within 30 days, and 30 cases died during the follow-up period (median: 13 months). The mean CHA 2 DS 2 -VASc score was significantly higher in dead patients compared to survivors (3.61 + 1.35 vs 1.95 + 1.52, P < .01). In multivariate regression analysis, systolic pulmonary artery pressure (hazard ratio [HR]: 1.03, 95% confidence interval [CI]: 1.01-1.06, P ¼ .02), PESI score (HR: 1.010, 95% CI: 1.004-1.017, P < .01), and CHA 2 DS 2 -VASc score (HR: 1.67, 95% CI: 1.19-2.16, P < .01) were found to be independently correlated with mortality. The patients whose CHA 2 DS 2 -VASc score was between 1 and 3 had 5.67 times and patients whose CHA 2 DS 2 -VASc score was 4 had 16.8 times higher risk of mortality compared to patients with CHA 2 DS 2 -VASc score ¼ 0. Conclusion: Patients with higher CHA 2 DS 2 -VASc scores had higher rates of mortality after APE.

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“…However, it was recognised to also be usefulin the prediction of the severity of coronary artery disease [2] and coronary artery disease-related mortality due to the presence of some common risk factors [3]. It may also be used for prediction of mortality and morbidity in congestive heart failure patients who are candidates for cardiac re-synchronisation treatment [4] and thrombotic events developing after percutaneous coronary intervention (PCI) [5].…”

Section: Introductionmentioning

confidence: 99%

CHA2DS2-VASc score predicts contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction, who have undergone primary percutaneous coronary intervention

Çiçek¹,

Yıldırım²

2018

Kardiol Pol

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A b s t r a c t Background and aim:We aimed to investigate the predictive value of the CHA 2 DS 2 -VASc score in the development of contrast-induced nephropathy (CIN). Methods:A total of 2972 patients who had been diagnosed with ST elevation myocardial infarction (STEMI) and who had undergone primary coronary angioplasty were included in the study. The patients were divided into three groups according to the CHA 2 DS 2 -VASc score, i.e.: low risk (1 point), intermediate risk (2 points), and high risk (≥ 3 points). The groups were followed with regard to CIN development. Results:The median CHA 2 DS 2 -VASc score was significantly higher in the CIN(+) group compared to the CIN(-) group (3 vs. 2, p < 0.001). The rate of CIN was 3.32-fold higher (OR 3.32, 95% CI 1.98-5.55, p < 0.001) in the high-risk group (CHA 2 DS 2 -VASc ≥ 3) compared to the low-risk group (CHA 2 DS 2 -VASc = 1). Age (OR 1.25, 95% CI 1.14-1.36, p < 0.001), female gender (OR 1.52, 95% CI 1.23-1.89, p < 0.001), hypertension (OR 1.50, 95% CI 1.265-1.78, p < 0.001), peak creatinine kinase-MB (OR 1.15, 95% CI 1.10-1.21, p < 0.001), and the Killip score > 1 (OR 4.25, 95% CI 3.10-5.82, p < 0.001) were found to be independent predictors for CIN development. Conclusions:The CHA 2 DS 2 -VASc score is an independent and strong predictor of CIN development in patients with acute STEMI.

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Prediction of Coronary Artery Disease Severity Using CHADS2 and CHA2DS2-VASc Scores and a Newly Defined CHA2DS2-VASc-HS Score

Cited by 93 publications

References 24 publications

Predictive value of newly defined CHA2DS2-VASc-HSF score for severity of coronary artery disease in ST segment elevation myocardial infarction

Predictive value of newly defined CHA2DS2-VASc-HSF score for severity of coronary artery disease in ST segment elevation myocardial infarction

Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

CHA2DS2-VASc score predicts contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction, who have undergone primary percutaneous coronary intervention

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Prediction of Coronary Artery Disease Severity Using CHADS2 and CHA2DS2-VASc Scores and a Newly Defined CHA2DS2-VASc-HS Score

Cited by 93 publications

References 24 publications

Predictive value of newly defined CHA2DS2-VASc-HSF score for severity of coronary artery disease in ST segment elevation myocardial infarction

Predictive value of newly defined CHA2DS2-VASc-HSF score for severity of coronary artery disease in ST segment elevation myocardial infarction

Higher CHA2DS2-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism

CHA2DS2-VASc score predicts contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction, who have undergone primary percutaneous coronary intervention

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Higher CHA₂DS₂-VASc Score Is Associated With Increased Mortality in Acute Pulmonary Embolism