2016
DOI: 10.1186/s12887-016-0559-0
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Prediction of congenital hypothyroidism based on initial screening thyroid-stimulating-hormone

Abstract: BackgroundIn thyroid-stimulating-hormone (TSH)-based newborn congenital hypothyroidism (CH) screening programs, the optimal screening-TSH cutoff level is critical to ensuring that true cases of CH are not missed. Screening-TSH results can also be used to predict the likelihood of CH and guide appropriate clinical management. The purpose of this study is to evaluate the predictive value of various screening-TSH levels in predicting a diagnosis of CH in the Ontario Newborn Screening Program (ONSP).MethodsThe ini… Show more

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Cited by 34 publications
(26 citation statements)
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“…Congenital hypothyroidism (CH) includes all conditions in which exist insufficient function of the thyroid gland, regardless of etiology, and is clinically or laboratory detected at birth. The incidence of CH of 1:1,500 is comparable to reports in other jurisdictions (1,2). The disease is twice as common in female children.…”
Section: Introductionsupporting
confidence: 79%
“…Congenital hypothyroidism (CH) includes all conditions in which exist insufficient function of the thyroid gland, regardless of etiology, and is clinically or laboratory detected at birth. The incidence of CH of 1:1,500 is comparable to reports in other jurisdictions (1,2). The disease is twice as common in female children.…”
Section: Introductionsupporting
confidence: 79%
“…However, very few of our participants had clinically elevated TSH (0.4%) while more had clinically low TSH (6.3%). Thus, we had very little data to examine whether clinically elevated TSH, a generally rare (occurring in approximately 1:1,000 newborns) but strong predictor of congenital hypothyroidism, was associated with ASD [Hinton et al, ; Saleh et al, ]. Causes of atypically low TSH are diverse, with presentations in hyperthyroid or, more rarely, in hypothyroid disorders possibly due to a dysfunctional feedback loop [Rose et al, ].…”
Section: Discussionmentioning
confidence: 99%
“…A newborn screen for congenital hypothyroidism was considered positive if the infant filter paper TSH was > 17 μIU/ml in whole blood [20,21]. Based on the World Health Organization's (WHO) classification, maternal urine iodine concentration was further disaggregated into: severe iodine deficiency (< 20 μg/L); moderate iodine deficiency (20-49 μg/L); mild iodine deficiency (50-99 μg/L); sufficient iodine level (100-199 μg/L); above requirements (200-299 μg/L); and excessive iodine intake (> 300 μg/L).…”
Section: Definitionsmentioning
confidence: 99%