Prediction of caries increment in Scottish adolescents

Russell, J. I.; MacFarlane, T. W.; Aitchison, Tom; Stephen, K.W.; Burchell, C.K.

doi:10.1111/j.1600-0528.1991.tb00114.x

Cited by 61 publications

(49 citation statements)

References 12 publications

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“…Our data were also in line with previous observations showing no correla- tion between the salivary secretion rate and the DMFT index [Birkhed and Heintze, 1989;Russell et al, 1990Russell et al, , 1991. A novel and interesting finding was that the salivary CA VI concentration exhibits a negative correlation with the DMFT index.…”

Section: Discussionsupporting

confidence: 82%

“…In dental caries, the hard tissues of the teeth are demineralized in the acidic environment produced by the bacterial metabolism. Salivary pH and buffering capacity are known to be central factors protecting teeth from caries [Birkhed and Heintze, 1989;Russell et al, 1990Russell et al, , 1991Wolinsky, 1994]. According to our present results, the salivary CA VI concentration seems to be as important a factor as the pH and buffering capacity in reducing the individual's susceptibility to caries (table 1).…”

Section: Discussionsupporting

confidence: 57%

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A Low Concentration of Carbonic Anhydrase Isoenzyme VI in Whole Saliva Is Associated with Caries Prevalence

Kivelä

Parkkila²,

Parkkila³

et al. 1999

Caries Res

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Carbonic anhydrases maintain pH homeostasis in various tissues of the human body by catalyzing the reversible reaction CO₂ + H₂O <=> HCO₃^– + H⁺. Carbonic anhydrase isoenzyme VI (CA VI) is secreted into human saliva by the serous acinar cells of the parotid and submandibular glands. Although it represents about 3% of the total protein in stimulated parotid saliva, its exact physiological significance in the saliva has not been established. In the present study, saliva samples were collected under strictly controlled conditions from young, healthy men and assayed for CA VI concentrations using a specific time–resolved immunofluorometric assay. Salivary secretion rate, pH, buffering capacity, α–amylase activity levels, lactobacillus and Streptococcus mutans counts were also determined, and the results were correlated with the dental status of the subjects. Salivary CA VI concentration, pH and buffering capacity values correlated negatively with the numbers of decayed, missing and filled teeth (DMFT index). The correlations between salivary CA VI concentration and DMFT index were most significant in subjects with poor oral hygiene. No correlation was found between salivary CA VI concentration and lactobacillus or Streptococcus mutans counts. As predicted, salivary lactobacillus and Streptococcus mutans counts showed a close positive correlation with the DMFT index. In contrast, no significant correlation was seen between salivary secretion rate or amylase activity and the DMFT index. The present results indicate that low salivary CA VI concentrations are associated with increased caries prevalence, particularly in subjects with neglected oral hygiene.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionsupporting

confidence: 57%

A Low Concentration of Carbonic Anhydrase Isoenzyme VI in Whole Saliva Is Associated with Caries Prevalence

Kivelä

Parkkila²,

Parkkila³

et al. 1999

Caries Res

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show abstract

“…Lactobacilli levels also have been used, but they do not seem to be as effective as caries predictors as the S. mutans. [25][26][27][28] In this study, salivary Lactobacilli weren't statistically different in the study and reference groups that support the Wahlin and Holm [29] and Ou-Yang et al results. [12] The effects of chemotherapy on human salivary glands and the composition of human saliva are difficult to assess, and available information is relatively sparse and often contradictory.…”

Section: Discussionsupporting

confidence: 75%

Untitled

Bassir

2017

AJP

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Purpose: This study was aimed to evaluate the caries activity in children with acute lymphoblastic leukemia (ALL) undergoing maintenance stage chemotherapy courses. Materials and Methods: This is an observationalanalytical and case-control study conducted on the 27 children (4-12 years old) with ALL who were in the maintenance phase of chemotherapy in the Ahvaz Shafa Hospital, Iran. The participants of the control group, matched in terms of age, gender, and cultural status with the case group, were selected among the healthy children referred to Ahvaz Razi Hospital, Iran. The children received only a clinical dental examination without radiographs. The number of decayed (D), missing (M) and filled (F), and teeth (T) were recorded based on the WHO based DMFT index and without the use of radiography. Then, after radiographic assessment, the stimulated saliva samples were collected from the subjects to assess the salivary Streptococcus mutans counts, salivary Lactobacilli counts, and salivary buffer capacity. Results: The salivary S. mutans counts in ALL children were significantly higher than the control group (P < 0.001). In both groups, Lactobacilli counts and salivary pH and DMFT were similar (P > 0.05). Furthermore, the ALL group tended to have lower salivary flow rate than healthy subjects (P < 0.05). Conclusions: Specific oral prevention regimes should be planned with more cautions for children suffered hematology illness undergoing antineoplastic therapy with respect to children without blood problems.

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“…Studies on caries risk assessment have shown that past caries experience variables compared to other variables had a relatively strong association with caries increment and that caries experience was the best predictor of caries increment in children with a mixed dentition [Klock and Krasse, 1979;Honkala et al, 1984;Wilson and Ashley, 1989;Alaluusua et al, 1990;Russell et al, 1991;Disney et al, 1992;Alaluusua, 1993;Mattiasson-Robertson and Twetman, 1993;Raitio et al, 1996]. A recent study, which used the area under the ROC curve as a method to compare the prognostic accuracy of various predictors, has reported no appreciable effect when additional predictors such as mutans streptococci and lactobacilli counts, salivary flow rate, sucrose intake frequency, brushing frequency and social group were applied in combination with past caries experience [Hausen, 1997].…”

mentioning

confidence: 99%

Prognosis of Caries Increment with Past Caries Experience Variables

Helderman¹,

Hof

Loveren

2001

Caries Res

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This study aimed to select past caries experience variables as caries predictors and to compare their prognostic accuracy with the variables used in a method of caries prognosis developed in a Swiss child population. The data used for the analyses originated from an 8–year longitudinal study starting in 1980 on caries of 7.5–year–old Dutch children. Stepwise logistic regression analyses provided predictor variables. The newly introduced variables D₂₃fi, D₁₂₃fi and D₂₃pifi were interchangeable and the most powerful caries predictors. For the sake of uniformity and ease of application, D₂₃fi (number of fissures of the permanent first molar with non–cavitated or cavitated caries lesions) was chosen as the first variable in the logistic regression equations. The gain in accuracy of the second and third predictor variables (number of sound primary molars and the number of buccal and lingual smooth surfaces of the permanent first molar with non–cavitated or cavitated caries) in the regression equations was limited. The D₁ condition of surfaces could be omitted from the prediction models. The present forced three–predictor–regression equations for 7.5–, 9.5– and 11.5–year–old children were evaluated to assess their prognostic performance by using the area under the ROC curve as a measure of prognostic quality. For the present regression equations, the area under the ROC curve was 81–87%, which was higher compared to the Swiss regression equations for caries prognosis.

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Prediction of caries increment in Scottish adolescents

Cited by 61 publications

References 12 publications

A Low Concentration of Carbonic Anhydrase Isoenzyme VI in Whole Saliva Is Associated with Caries Prevalence

A Low Concentration of Carbonic Anhydrase Isoenzyme VI in Whole Saliva Is Associated with Caries Prevalence

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Prognosis of Caries Increment with Past Caries Experience Variables

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