Prediction of biological characteristics of breast cancer using dual-phase FDG PET/CT

Sasada, Shinsuke; Masumoto, Norio; Suzuki, Eri; Sueoka, Satoshi; Goda, Noriko; Kajitani, Keiko; Emi, Akiko; Kadoya, Takayuki; Okada, Minoru

doi:10.1007/s00259-019-4259-5

Cited by 19 publications

(17 citation statements)

References 21 publications

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“…In the study that Sasada et al (22) evaluated a total of 1122 invasive breast cancers, 30 of which were ILC, in late imaging, the value we defined as Δ in our study is expressed as retention index (RI). Although there was no significant difference in our study, SUV max in the HER-2 positive group is higher than the group where MTV and TLG median values were negative (Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…It is known that late imaging contributes to the diagnosis in malignancies, where the imaging quality will be optimal as much as the radiopharmaceutical half-life allows (12). There are many studies reporting that late image in FDG-PET in breast cancer significantly increases sensitivity and specificity (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). However, these studies mostly consist of IDC patients.…”

Section: Introductionmentioning

confidence: 99%

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Contribution of Fluorodeoxyglucose-Positron Emission Tomography Late Imaging to Diagnosis and Correlation with Histopathology in Invasive Lobular Breast Cancer

Falay¹,

Seymen²

2020

jarem

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The aim of this study was to investigate the correlation between primary lesion and contralateral breast tissue metabolic parameters in standard and delayed images obtained on preoperative F-18-fluorodeoxyglucose (FDG) positron emission tomography (PET) and the correlation with pathological variables of primary lesion in invasive lobular breast cancer (ILC). Methods: Seventeen ILC cases in which standard and late FDG-PET imaging were performed between 2007 and 2018 were included in the study. SUV max , metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values and change rates (Δ) of primary malignant lesion and contralateral breast control area were recorded. T and N-stages, histological and nuclear grades of primary malignancy, estrogen receptor (ER), progesterone receptor, presence of human epidermal growth factor receptor (HER)-2 and Ki-67 values are compared with FDG-PET values. Results: No statistically significant correlation was found between metabolic parameters and histopathological components of 17 ILC patients (median age: 45 years) after surgery (11 breast conserving surgery, 6 mastectomy). Among the metabolic parameters obtained from contralateral breast tissue, SUV max-based ones [standard(s)-SUV max , late(g)-SUV max , ΔSUV max ] showed statistically significant differences with malignancy (p<0.000). Conclusion: Especially the negative median value of the control SUV max suggests that late imaging may provide additional contribution, especially in the dense breast tissue, in the ILC with high probability of multifocality/multicentricity. Although there was no statistically significant difference with histopathological components, parallel results (such as high Δ-TLG in presence of lymph node metastasis, HER-2 positive and high SUV max , MTV and TLG median values in ER negative cases) were seen with the literature mostly consisting of invasive ductal carcinoma. Confirmation of this important information obtained only from ILC patients is required in multicentre studies or meta-analyzes in which the number of cases will be higher.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Contribution of Fluorodeoxyglucose-Positron Emission Tomography Late Imaging to Diagnosis and Correlation with Histopathology in Invasive Lobular Breast Cancer

Falay¹,

Seymen²

2020

jarem

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“…Dans une sé rie de 32 patientes atteintes d'un cancer du sein, Chang et al ont montré que le RI (1 h-2 h) de la né oplasie primitive et des ganglions axillaires homolaté raux atteints é tait corré lé au statut HER2 mais pas au statut ER, PR, triple né gatif ni au p53 [67]. Dans une population de 78 [71]. Ils ont ainsi montré que le RI é tait associé aux caracté ristiques malignes de la tumeur (taille, grade, infiltration lymphovasculaire, HER2+, triplené gatif), mais uniquement quand la lé sion pré sentait une SUVmax initiale supé rieure à 1,4, et à diffé rencier les sous-types molé culaires.…”

Section: Cancers Mammairesunclassified

“…Dans une population de 78 patientes, Ozen et al n'ont pas montré de corré lation significative entre le RI mesuré sur la né oplasie mammaire primitive et la pré sence d'une atteinte ganglionnaire mé tastatique au niveau axillaire, au contraire des SUVmax pré coce et tardive [68]. Enfin, ré cemment, dans une population de 1523 patientes, Sasada et al ont montré que le RI de la né oplasie mammaire primitive (1 h-2 h) é tait corré lé à la pré sence d'une invasion mé tastatique ganglionnaire pour les lé sions avec une SUVmax initiale supé rieure ou é gale à 1,4 [71].…”

Section: Cancers Mammairesunclassified

TEP/TDM multi-phase : revue de la littérature

2021

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“…Additionally, PET/ CT is clinically indicated only for stage III breast cancer patients and so stage I and II breast cancers, which represent the majority, have been excluded from the analysis of these retrospective datasets. Radiogenomic analyses to date have principally focused on metabolic activity parameters of the primary tumor, most commonly via analysis of the maximum standardized uptake values, but also via analysis of the metabolic tumor volume and total lesion glycolysis (30)(31)(32)(33)(34)(35)(36)(37)(38)(39). While more advanced metrics such as histogram-based features have only recently been explored (30).…”

Section: Fdg Pet/ctmentioning

confidence: 99%