Prediction of Areal Bone Mineral Density and Bone Mineral Content in Children and Adolescents Living With HIV Based on Anthropometric Variables

Lima, Luiz Rodrigo Augustemak de; Krug, Rodrigo de Rosso; Silva, Rosane Carla Rosendo da; Carvalho, Aroldo P. de; González‐Chica, David Alejandro; Back, Isabela de Carlos; Petroski, Édio Luiz

doi:10.1016/j.jocd.2015.06.001

Cited by 10 publications

(15 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Using height, weight, arm circumference, body mass index, and femoral diameter, with age and skin color adjusted by sex, the models predicted 84% and 94% of aBMD and BMC, respectively. With subsequent validation in other populations, these models could allow an alternative for bone health monitoring in resource-limited settings 13 .…”

Section: Assessing Bone Health In Hiv-infected Children and Adolescentsmentioning

confidence: 99%

Bone health in HIV-infected children and adolescents

Eckard

Mora

2016

Current Opinion in HIV and AIDS

View full text Add to dashboard Cite

Purpose of review Chronic HIV infection and exposure to antiretroviral therapy compromises bone health in children and adolescents, potentially impacting their long-term quality of life. Thus, the purpose of this paper is to review the most recent literature on this topic in HIV-infected children and adolescents. Recent findings Recent studies continue to demonstrate bone abnormalities in HIV-infected children and adolescents, whether HIV is acquired perinatally or during adolescence. Researchers have employed new modalities, both high tech and those that can be utilized in resource-limited settings, to better assess bone health. New data suggest that this population may also be experiencing an increase incidence of factures, and they may not acquire the same peak bone mass as their HIV-uninfected counterparts. Reassuringly, however, in utero tenofovir exposure does not appear to have a significant impact on bone health in HIV-exposed, uninfected infants. Summary Recent findings underscore the need for further research on bone in HIV-infected children and adolescents. Longitudinal studies are especially needed to evaluate long-term risk of osteoporosis and fractures, since this population is exposed to HIV and antiretroviral therapy for many decades starting early in life and during the most critical time for skeletal growth and bone mass accrual.

show abstract

Section: Assessing Bone Health In Hiv-infected Children and Adolescentsmentioning

confidence: 99%

Bone health in HIV-infected children and adolescents

Eckard

Mora

2016

Current Opinion in HIV and AIDS

View full text Add to dashboard Cite

show abstract

“…Daily consumption of ART and immune-activation is related to the virus itself lead to important side effects, which become particularly evident in vertically infected patients, due to life-long exposure to both drugs and virus [1]. Two important and well documented side-effects are bone homeostasis impairment and reduction of bone mineral density (BMD) [2–4].…”

Section: Introductionmentioning

confidence: 99%

Impact of HIV-1 Infection and Antiretroviral Therapy on Bone Homeostasis and Mineral Density in Vertically Infected Patients

Donà

Mozzo

Luise³

et al. 2019

Journal of Osteoporosis

View full text Add to dashboard Cite

Daily assumption of antiretroviral drugs and HIV-related immune activation lead to important side effects, which are particularly evident in vertically infected patients. Bone homeostasis impairment and reduction of bone mineral density (BMD) is one of the most important side effects. Primary aim of this study is to assess the prevalence of bone homeostasis alterations in a group of vertically infected patients; secondary aim is to analyze the relationship between bone homeostasis alterations and anthropometric data, severity of HIV infection, and antiretroviral therapy. We studied 67 patients with vertically transmitted HIV-1 (aged 6-31 years), followed by the Pediatric Infectious Disease Unit of the University Hospital of Padua, Italy. We analyzed bone turnover markers (P1NP and CTx) and we performed lumbar spine and femoral dual energy X-ray absorption densitometry (DXA). Personal and anthropometric data and information on HIV-infection severity and antiretroviral therapy were collected for all patients. We found that BMD values recorded by DXA showed a significant correlation with age, race, BMI, physical activity, and antiretroviral therapy duration. P1NP was increased in 43% of patients, while CTX in 61% of them. P1NP alteration was related to age, race, BMI, physical activity, therapy duration, and ever use of protease inhibitors and nucleotide reverse transcriptase inhibitors. CTX alteration was found to be correlated only with age. In conclusion, our study confirms that a wide percentage of HIV vertically infected patients show reduced BMD and impaired bone homeostasis. Strict monitoring is needed in order to early identify and treat these conditions.

show abstract

“…Also recreational handball represents intermittent high-intensity exercise leading to beneficial effects on BMD, muscle mass, and performance skeletal size was confirmed (de Lima et al 2016;Chowdhury and Bandyopadhyay 2014). For children and adolescents living with human immunodeficiency virus predictive equations have been developed for bone mineral content and BMD based on anthropometric variables such as height, arm circumference and femoral diameter (de Lima et al 2016). In healthy Indian women age 40-75, skeletal mass assessed by humerus, wrist, femur and ankle breadth were variables for prediction of BMD in elderly women (Chowdhury and Bandyopadhyay 2014).…”

Section: Discussionmentioning

confidence: 80%

“…The higher BMD of the athletes' skeleton at different measured sites, forearm (Boshnjaku et al 2015) or spine and femur (Mrabet et al 2013), was associated with the effect of regular practice of handball. Also recreational handball represents intermittent high-intensity exercise leading to beneficial effects on BMD, muscle mass, and performance skeletal size was confirmed (de Lima et al 2016;Chowdhury and Bandyopadhyay 2014). For children and adolescents living with human immunodeficiency virus predictive equations have been developed for bone mineral content and BMD based on anthropometric variables such as height, arm circumference and femoral diameter (de Lima et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Anthropometric profile of female handball players is related to bone mineral density

Pastuszak

Górski

Gajewski

et al. 2018

View full text Add to dashboard Cite

The aim of this study was to evaluate the relationship of a wide range of anthropometric parameters with BMD in normal-weight women: handball players and healthy untrained students. Thirteen former female handball players, (age 21.2±0.9 years, body mass 64.2±6.1 kg, training experience 6.7±2.4 years) and 51 randomly selected untrained students (age 20.6±1.2 years, body mass 58.1±6.8 kg), were examined. The anthropometric measurements included 16 variables. BMD was measured on the radius of the non-dominant hand at distal and proximal points with dual-energy X-ray absorptiometry (DXA), using a Norland pDEXA densitometer. Relationships between BMD and anthropometric variables were assessed in 64 normal-weight women (BMI≥18.5 and ≤ 24.99 kg/m2), by calculating Pearson’s linear correlation coefficient. We found a significant positive relationship between bone mass characteristics and biacromial breadth (0.30-0.53), calf (0.28-0.47) and arm (0.27-0.42) girth corrected, and lean body mass (LBM) (kg) (0.38-0.61) and (%) (0,27) in the group of normal-weight women. The student groups were significantly different (analysis of variance with Scheffé post hoc test, p<0.001) in BMD, bone mineral content (BMC) and Z-score at both measured points. The former handball players were also characterized by higher body mass and LBM (kg), as well as corrected body girths and biacromial breadth (p<0.001), compared to untrained students. The groups did not differ significantly in body height or total fat. The morphological profile of the female handball players is conducive to BMD. Skeletal characteristics and muscle tissue had a significant beneficial effect on bone mineral characteristics in young women with normal weight.

show abstract

Prediction of Areal Bone Mineral Density and Bone Mineral Content in Children and Adolescents Living With HIV Based on Anthropometric Variables

Cited by 10 publications

References 24 publications

Bone health in HIV-infected children and adolescents

Bone health in HIV-infected children and adolescents

Impact of HIV-1 Infection and Antiretroviral Therapy on Bone Homeostasis and Mineral Density in Vertically Infected Patients

Anthropometric profile of female handball players is related to bone mineral density

Contact Info

Product

Resources

About