Prediction of anti-plasmodial activity of Artemisia annua extracts: application of NMR spectroscopy and chemometrics

Bailey, Nigel J.; Wang, Yulan; Sampson, Julia; Davis, Wendy A.; Whitcombe, Ian; Hylands, Peter J.; Croft, Simon L.; Holmes, Elaine

doi:10.1016/j.jpba.2003.12.024

Cited by 67 publications

(55 citation statements)

References 30 publications

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“…12.12 PLS-DA Y-predicted scatter plot for classes ToxED 50 > 65 μg/ml (class 0, squares) and ToxED 50 < 65 μg/ml (class 1, circles). Training set represented by closed shapes, (black filled square) and (black filled circle), test set represented by open shapes, (white square) and (white circle) (Reprinted from Bailey et al (2004). Copyright © 2004, with permission from Elsevier) control of herbal medicine based on molecular composition.…”

Section: Resultsmentioning

confidence: 99%

“…and Predict the Efficacy and Toxicity (Bailey et al 2004) Artemisia annua L. (also known as sweet wormwood or by its Chinese name qing hao) and the isolated constituent artemisinin have well-documented anti-plasmodial activity. It has been suggested that the efficacy of the A. annua plant itself derives from a synergistic effect and that it is a combination of constituents in the plant that confer the total anti-plasmodial activity.…”

Section: Artemisia Annua L As An Example To Studymentioning

confidence: 99%

“…Region δ2.5-8.5 is expanded vertically by a factor of 6 to allow observation of lower level aromatic resonances. Resonances attributable to artemisinin are indicated with an "A" (Reprinted from Bailey et al (2004). Copyright © 2004, with permission from Elsevier) resulting PCA score plot can be seen in Fig.…”

Section: The Metabolic Fingerprint Of Artemisia Annuamentioning

confidence: 99%

“…12.10 PCA score plot for A. annua plant extracts. Samples are separated into three groups, IC 50 < 0.1 μg/ml (black filled triangle), 0.1 μg/ml < IC 50 < 1 μg/ml (white diamond), and IC 50 > 1 μg/ml (black filled circle) (Reprinted from Bailey et al (2004). Copyright © 2004, with permission from Elsevier) analyzing the PCA loading plot, it was possible to determine the variables (spectral regions) that are responsible for this separation and are thus the regions that have greatest variation between the extracts.…”

Section: The Metabolic Fingerprint Of Artemisia Annuamentioning

confidence: 99%

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NMR-Based Metabolomic Methods and Applications

Xiao

Wang

2014

Plant Metabolomics

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Section: Resultsmentioning

confidence: 99%

Section: Artemisia Annua L As An Example To Studymentioning

confidence: 99%

Section: The Metabolic Fingerprint Of Artemisia Annuamentioning

confidence: 99%

Section: The Metabolic Fingerprint Of Artemisia Annuamentioning

confidence: 99%

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NMR-Based Metabolomic Methods and Applications

Xiao

Wang

2014

Plant Metabolomics

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“…The biological properties of several species of Asteraceae have been evaluated for antiprotozoal (Bailey et al, 2004;TalebContini et al, 2004) and antimicrobial (Salie et al, 1996;Stojanović et al, 2005) activities. As a result of these evaluations, artemisinin has been isolated from Artemisia annua L. (Asteraceae) and has well-documented antiplasmodial activity (Dhingra et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Antiprotozoal and Antimicrobial Activities ofCentaurea. Species Growing in Turkey

Karamenderes

Khan

Tekwani

et al. 2006

Pharmaceutical Biology

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Nuclear Magnetic Resonance as Analytical Tool for Crude Plant Extracts

Bilia

2014

Encyclopedia of Analytical Chemistry

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Authentication, quality control, and stability testing of crude plant extracts are generally achieved and well established through HPLC, HPTLC, and capillary GC, using specific detectors such as UV–vis, RI, and coupled systems (MS), which allow the qualitative and quantitative determination of the composition of the markers or active substances. The major disadvantages of these conventional methods lie in the time consuming for the development of simple and rapid chromatographic separation and for the preparation of samples before measurements. In addition, these techniques are not able to reveal unknown plant metabolites that can contribute to the biological activity. NMR spectroscopy is nondestructive, selective, and capable of simultaneous detection of a great number of constituents. The identification by NMR provides on both major and minor components, with no restrictions relating to volatility, polarity, or the presence of specific chromophores. Finally, the method can be applied without knowledge of the composition of the sample. NMR spectra contain information about the identity of the molecules in the extracts and are useful to quantify the constituents. NMR spectroscopy coupled with chemometric tools has been successfully applied to the characterization of various herbs and plant extracts for quality control, authentication, determining geographical origin, and detecting adulteration of herbal drugs and extracts.

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Prediction of anti-plasmodial activity of Artemisia annua extracts: application of NMR spectroscopy and chemometrics

Cited by 67 publications

References 30 publications

NMR-Based Metabolomic Methods and Applications

NMR-Based Metabolomic Methods and Applications

Antiprotozoal and Antimicrobial Activities ofCentaurea. Species Growing in Turkey

Nuclear Magnetic Resonance as Analytical Tool for Crude Plant Extracts

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