Prediction of Abstinence in Opioid-Dependent Patients

Dijkstra, B.A.G.; Jong, C.A.J. de; Krabbe, Paul F M; Staak, C.P.F. van der

doi:10.1097/adm.0b013e31818a6596

Cited by 15 publications

(9 citation statements)

References 41 publications

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“…Paradoxically, one recent study reported that poor sleep during opioid detoxification was associated with abstinence during a 4-week follow-up period 50. The authors speculated that treatment staff may have given more attention to poor sleepers, resulting in better outcomes, but they could not support that explanation with data.…”

Section: Evidence That Sleep Predicts Relapse Across Psychoactive Submentioning

confidence: 98%

Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances

2010

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Relapse to uncontrolled use of a psychoactive substance is arguably the single most defining characteristic of an addiction. Relapse following addiction treatment is very common with serious consequences to individuals, families, and the public system of care, making predictors of relapse a highly significant area of study. Before the turn of the century, most of the addiction treatment outcome literature focused on psychosocial predictors of relapse. More recently, investigating biological predictors of relapse specifically and treatment outcome broadly has gained momentum. This line of research has linked sleep disturbances to the risk of relapse among persons who are recovering from an alcohol addiction. Given common neurobiological and psychosocial processes in sleep and addictive behaviors, we hypothesize that the link between sleep disturbance and relapse risk observed among alcohol addiction generalizes to all other types of psychoactive substances. This hypothesis has the potential for helping develop more effective and targeted treatment approaches for persons with addiction. As initial support for the hypothesis, this paper reviews evidence on common neurobiological processes among various types of psychoactive substances that suggests sleep is a universal risk factor for relapse. A conceptual framework is also presented to articulate causal mechanisms. The paper concludes with implications for research and practice.

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Section: Evidence That Sleep Predicts Relapse Across Psychoactive Submentioning

confidence: 98%

Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances

2010

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“…Sleep disturbance has been identified as a risk factor for relapse in addiction to a range of substances (see Brower & Perron, 2010 for review), including alcohol (Brower, Aldrich, & Hall, 1998), nicotine (Boutou et al, 2008), and cocaine (Sofuoglu et al, 2005). Much less work has documented the role of sleep in relapse in the context of opioid dependence (see Dijkstra et al, 2008 for an exception) despite observations of sleep disruption during opiate withdrawal (Wang & Teichtahl, 2007). To gain further insight into the effects of sleep disruption in patients in treatment for NMUPD, this study examined the effects of sleep quality on craving – a proximal outcome associated with subsequent opioid use (Tsui et al, 2014) – through the indirect associations with positive affect (PA) and negative affect (NA) at the day-to-day, within-person level.…”

Section: Introductionmentioning

confidence: 99%

Daily sleep quality affects drug craving, partially through indirect associations with positive affect, in patients in treatment for nonmedical use of prescription drugs

Lydon‐Staley

Cleveland

Huhn

et al. 2017

Addictive Behaviors

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Objective Sleep disturbance has been identified as a risk factor for relapse in addiction to a range of substances. The relationship between sleep quality and treatment outcome has received relatively little attention in research on nonmedical use of prescription drugs (NMUPD). This study examined the within-person association between sleep quality and craving in medically detoxified patients in residence for the treatment of NMUPD. Method Participants (n= 68) provided daily reports of their sleep quality, negative affect (NA), positive affect (PA), and craving for an average of 9.36 (SD= 2.99) days. Within-person associations of sleep quality and craving were examined using multilevel modeling. Within-person mediation analyses were used to evaluate the mediating roles of NA and PA in the relationship between sleep quality and craving. Results Greater cravings were observed on days of lower than usual sleep quality (γ10 = −0.10, p = .003). Thirty-one percent of the overall association between sleep quality and craving was explained by PA, such that poorer sleep quality was associated with lower PA and, in turn, lower PA was associated with greater craving. No evidence emerged for an indirect association between sleep quality and craving through NA. Conclusions Daily fluctuations in sleep quality were associated with fluctuations in craving, an association partially explained by the association between sleep quality and daily PA. These data encourage further research on the relationship between sleep, affect, and craving in NMUPD patients, as well as in patients with other substance use disorders.

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“…Variables of interest included socio‐demographic and clinical characteristics that have shown to influence opioid withdrawal expression and/or naltrexone induction, including age, gender, injection drug use (IDU), daily quantity, and time from last use at admission . Exploratory analyses were conducted by using Spearman correlation coefficients to assess the nature of potential relationships between day‐2 withdrawal changes, behavioral and biological variables, and induction onto XR‐NTX.…”

Section: Methodsmentioning

confidence: 99%

Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone

Mannelli

Swartz

Wu³

2018

American J Addict

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Prediction of Abstinence in Opioid-Dependent Patients

Cited by 15 publications

References 41 publications

Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances

Sleep disturbance as a universal risk factor for relapse in addictions to psychoactive substances

Daily sleep quality affects drug craving, partially through indirect associations with positive affect, in patients in treatment for nonmedical use of prescription drugs

Withdrawal severity and early response to treatment in the outpatient transition from opioid use to extended release naltrexone

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