Prediction of 10-year coronary heart disease risk in Caribbean type 2 diabetic patients using the UKPDS risk engine

Ezenwaka, Chidum E.; Nwagbara, E; Seales, D; Okali, F; Hussaini, Syed Asadullah; Raja, B; A, Jones-Lecointe; Sell, Henrike; Avci, Haluk; Eckel, Jürgen

doi:10.1016/j.ijcard.2007.12.005

Cited by 10 publications

(6 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, males with T2DM compared to females had a significantly lower proportion with a moderate or greater risk category. This is inconsistent with a Caribbean study, which reported a relatively higher proportion of male patients at > 15% 10-year ICVD risk compared to females (60.4% vs 30.6%) [26]. This difference in results might be due to different models and algorithms for CVD risk calculation with different risk categories in different races.…”

Section: Discussionmentioning

confidence: 64%

Sex differences in 10-year ischemic cardiovascular disease risk prediction in Chinese patients with prediabetes and type 2 diabetes

Yang

Fish

Zhu

et al. 2019

BMC Cardiovasc Disord

View full text Add to dashboard Cite

BackgroundCardiovascular disease has become a serious public health problem in recent years in China. The aim of the study was to examine sex differences in cardiovascular risk factors and 10-year ischemic cardiovascular disease (ICVD) risk in Chinese patients with prediabetes (PreDM) and type 2 diabetes mellitus (T2DM).MethodsThis was a multi-site retrospective case-control study conducted from April–November 2016 using an electronic medical record database, involving 217 PreDM and 900 T2DM patients admitted to endocrinology units in four hospitals in China. CVD risk was estimated using the Chinese 10-year ICVD risk model. The differences in 10-year absolute ICVD risk according to PreDM, T2DM < 1 year, T2DM 1–5 years or T2DM ≥5 years and sex were analyzed using ANOVA.ResultsWhen compared to PreDM females, males with PreDM had significantly higher 10-year ICVD risk In contrast, the opposite pattern of 10-year ICVD risk was observed in T2DM; males had significantly lower 10-year ICVD risk. Moreover, compared to T2DM females, males with T2DM had a lower proportion s with moderate or greater ICVD risk (p < 0.001). When compared to PreDM males, males with T2DM < 1 year, and with T2DM 1–5 years had no difference in 10-year ICVD risk, but had higher ICVD risk with T2DM ≥5 years (p < 0.05). Compared to PreDM females, females with T2DM in all subgroups had higher ICVD risk (p < 0.05). Among those with T2DM, hypertension rates of awareness, treatment and control were 78.60%, 65.38% and 31.10%, respectively; hyperlipidemia rates of awareness, treatment and control were lower (29.15%, 8.30% and 3.47%, respectively). Females with T2DM had higher prevalence, awareness and treatment of hypertension and hyperlipidemia than males with T2DM (p < 0.001).ConclusionsThere is a greater need for cardiovascular risk reduction programs for females with T2DM at diagnosis. Given the low numbers for awareness, treatment and control of hypertension and hyperlipidemia in both males and females, significant resources focused on them must be expended, specifically improving regular assessment of blood pressure and blood lipids. Strengthening the management of chronic diseases through adherence to evidence-based guidelines to enhance clinical treatment may reduce 10-year ICVD in patients with T2DM in China.

show abstract

Section: Discussionmentioning

confidence: 64%

Sex differences in 10-year ischemic cardiovascular disease risk prediction in Chinese patients with prediabetes and type 2 diabetes

Yang

Fish

Zhu

et al. 2019

BMC Cardiovasc Disord

View full text Add to dashboard Cite

show abstract

“…Similarly, a report from the United States has identified ethnic-related difficulties in glycemic control among type 2 diabetic patients of African origin. [28,29] Although our previous report from this multiethnic population showed that patients of Indian origin had worse glycemic control than their counterparts of African origin, [14,16] one important observation in the current report is that the provision of facilities for self-monitoring of blood glucose improved both the glycemic control and 10-year CHD risk level in Afro-Caribbean patients studied.…”

Section: Discussionmentioning

confidence: 48%

“…It should, however, be noted that the risk of CHD is relatively low in the African or Afro-Caribbean population. [9,16] Indeed, the mean 10-year CHD risk score in this study is less than the 15% score the National Institute for Clinical Excellence (NICE) advocated for initiating statin treatment in the UK population. [30] However, the current study has interestingly demonstrated that the level of CHD risk in Afro-Caribbean women could be reduced further if the patients are empowered through self-monitoring of blood glucose.…”

Section: Discussionmentioning

confidence: 80%

“…[1,[8][9][10][11][12][13][14] Although cardiovascular disease is recognized as one of the leading causes of death in Trinidad and Tobago, [15] only one research report has characterized the CHD risk profile of diabetic patients in Trinidad and Tobago in quantitative terms. [16] A 10-year CHD risk can be estimated from the equations derived from the Framingham Heart Study [17] or the United Kingdom Prospective Diabetes Study (UKPDS) risk engine. [18] These two tools are comparable in estimating CHD risk levels.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Self-monitoring of blood glucose improved glycemic control and the 10-year coronary heart disease risk profile of female type 2 diabetes patients in Trinidad and Tobago

Dimgba

Okali

et al. 2011

Niger J Clin Pract

View full text Add to dashboard Cite

show abstract

“…In actuality, the UKPDS Risk Engine and the UKPDS Outcomes Model described below have been used extensively by modellers [38] to determine risk in individuals with diabetes [39] and to calculate cardiovascular risk as a primary outcome in interventional trials [40]. It has been used to assess the cost‐effectiveness of screening for diabetes [41] as well as for treatments [42].…”

Section: Simulation Of the Incidence Of Diabetic Complicationsmentioning

confidence: 99%

UKPDS—modelling of cardiovascular risk assessment and lifetime simulation of outcomes

Adler

2008

Diabetic Medicine

View full text Add to dashboard Cite

Although known principally as a clinical trial, the UK Prospective Diabetes Study (UKPDS) provided longitudinal data which helped define the natural history of cardiovascular complications in Type 2 diabetes. Using clinical, epidemiological, statistical and economics methods, UKPDS investigators developed mathematical models that helped define predictors (risk factors) for cardiovascular disease including angina, myocardial infarction, stroke, peripheral vascular disease and death in Type 2 diabetes. The UKPDS made clearer the contributions to risk of age, hyperglycaemia, elevated blood pressure, adverse blood lipids and smoking. Equations were developed, combined and incorporated into the UKPDS Risk Engine and the UKPDS Outcomes models. For example, the UKPDS risk engine-version 2-estimates that a white 62-year-old man with 11 years of Type 2 diabetes, a glycated haemoglobin of 8.3%, a systolic blood pressure of 145 mmHg and total and high-density lipoprotein cholesterol values of 5.8 and 1.1 mmol/l who did not smoke has a 33% chance of having overt coronary heart disease within 10 years. These models contribute to the estimation of risk and/or health outcomes adjusted for quality of life for use by, amongst others, clinicians, trialists, health planners, guideline developers and health economists.

show abstract

Prediction of 10-year coronary heart disease risk in Caribbean type 2 diabetic patients using the UKPDS risk engine

Cited by 10 publications

References 23 publications

Sex differences in 10-year ischemic cardiovascular disease risk prediction in Chinese patients with prediabetes and type 2 diabetes

Sex differences in 10-year ischemic cardiovascular disease risk prediction in Chinese patients with prediabetes and type 2 diabetes

Self-monitoring of blood glucose improved glycemic control and the 10-year coronary heart disease risk profile of female type 2 diabetes patients in Trinidad and Tobago

UKPDS—modelling of cardiovascular risk assessment and lifetime simulation of outcomes

Contact Info

Product

Resources

About