Prediction of 1-year clinical outcomes using the SYNTAX score in patients with prior heart failure undergoing percutaneous coronary intervention: sub-analysis of the SHINANO registry

Minamisawa, Masatoshi; Miura, Takashi; Motoki, Hirohiko; Kobayashi, Hideki; Kobayashi, Masanori; Nakajima, Hiroyuki; Kimura, Hironobu; Akanuma, Hiroshi; Mawatari, Eiichiro; Sato, Toshio; Hotta, Shoji; Kamiyoshi, Yuichi; Maruyama, Takuya; Watanabe, Noboru; Eisawa, Takayuki; Aso, Shinichi; Uchikawa, Shinichiro; Senda, Keisuke; Morita, Takehiro; Hashizume, Naoto; Abe, Naoyuki; Ebisawa, Soichiro; Izawa, Atsushi; Miyashita, Yusuke; Koyama, Jun; Ikeda, Uichi

doi:10.1007/s00380-016-0896-9

Cited by 14 publications

(14 citation statements)

References 30 publications

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“…SS is usually used for calculating the severity and complexity of CAD and as a guideline for interventional cardiologist to choose more appropriate treatment between percutaneous coronary intervention (PCI) and coronary artery bypass graft surgery [21]. There is increasing evidence that has proven that this scoring system could predict major adverse cardiovascular events in patients with ACS or undergoing PCI [22, 23]. As in line with previous studies, in the present study, patients with higher SS have higher in-hospital mortality rate than patients with lower SS [7].…”

Section: Discussionmentioning

confidence: 99%

Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease

et al. 2019

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Aims MicroRNAs (miRNAs) are associated with the pathogenesis of coronary artery disease (CAD). The objective of this study is to explore plasma levels of miR-208b and miR-499 in CAD and analyze its association with the severity of CAD. Materials and Methods 195 consecutive CAD patients who underwent coronary angiography were enrolled in this study. Severity of coronary lesions was evaluated by the synergy between percutaneous coronary intervention with taxus and cardiac surgery score (SYNTAX) score (SS). Plasma levels of miR-208b and miR-499 were assessed by quantitative real-time polymerase chain reaction (qRT-PCR). The relationship between miR-208b and miR-499 and SS was analyzed. Results The qRT-PCR results showed that plasma levels of miR-208b and miR-499 in SS > 32 (high SS) group was higher than those in low (SS ≤ 22) and intermediate (22 < SS ≤ 32) groups. Meanwhile, plasma miR-208b and miR-499 levels were significantly positive correlated with the SS (Spearman's r = 0.535 and r = 0.407, respectively; both p < 0.001). Multivariate logistic analysis results showed that miR-208b (odds ratio [OR]: 2.069; 95% confidence interval [CI]: 1.351-3.167; p = 0.001) and miR-499 (OR: 1.652; 95% CI: 1.222-2.233; p = 0.001) were independent predictors of high SS. In receiver operating characteristic curve, the area under the curve of miR-208b and miR-499 in prediction of high SS was 0.775 and 0.713, respectively. Conclusions Higher plasma levels of miR-208b and miR-499 were positively associated with the severity of CAD, and plasma miR-208b and miR-499 can act as potential biomarkers for estimating the severity of CAD.

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Section: Discussionmentioning

confidence: 99%

Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease

et al. 2019

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“…New scientific reports have shown that this scoring system is also capable of predicting major cardiovascular events in patients undergoing PCI. [2] In other words, patients with a high SYNTAX score had lesions that were more complicated and resulted in worst prognosis following PCI.…”

Section: Introductionmentioning

confidence: 99%

Use of the SYNTAX Score II to predict mortality in interventional cardiology

Yang¹,

Zhang

Xu³

2019

Medicine

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Background:As the SYNTAX Score has limitations, it should be replaced by another better angiographic tool. By comparing mortality that was observed following percutaneous coronary intervention (PCI) in patients who were allotted a low versus a high score, we aimed to systematically investigate mortality prediction using the SYNTAX Score II in Interventional Cardiology.Methods:Electronic databases were searched for relevant publications using the terms “SYNTAX Score II and percutaneous coronary intervention.” The main outcome was all-cause mortality. This analysis was carried out by the RevMan 5.3 software [risk ratios (RRs) and 95% confidence intervals (95% CIs) were calculated].Results:A total number of 9443 participants were enrolled for this analysis. As different studies reported different range of SYNTAX Score II, we further classified these scores range into 4 different groups: 17 < SS > 17, 20 < SS > 20, 22 < SS > 22, and 26 < SS > 26 appropriately. Results of this analysis showed that the risk of mortality in patients with a high SYNTAX Score II (SS > 17) was significantly higher (RR: 2.65, 95% CI: 1.05–6.73; P = .04) than patients with a low SYNTAX Score II (SS < 17). Even when participants with a low SYNTAX Score II (SS < 20) were compared with patients who were assigned to a higher SYNTAX Score II (SS > 20), a significantly higher risk of mortality was associated with a high SYNTAX Score II (RR: 3.73, 95% CI: 1.99 – 6.96; P = .0001).Conclusion:Following PCI, the risk of mortality was higher in those patients with a high SYNTAX Score II. The SYNTAX Score II might be considered as an important tool to predict mortality in Interventional Cardiology. Future research should further explore the benefits of this tool.

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“…To further support this analysis, the SHINANO registry showed SYNTAX score to be beneficial in predicting the incidence of MACEs following PCI 20 . That particular registry included patients with prior heart failure and coronary artery disease.…”

Section: Discussionmentioning

confidence: 95%

Percutaneous Coronary Intervention, Coronary Artery Bypass Surgery and the SYNTAX score: A systematic review and meta-analysis

Bundhun

Yanamala

Huang

2017

Sci Rep

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The SYNTAX [Synergy Between percutaneous coronary intervention (PCI) With Taxus and coronary artery bypass surgery (CABG)] score is a decision-making tool in interventional cardiology. However, several facts still remain to be addressed: What about PCI or CABG with a low versus a high score respectively? And what about PCI with a low score versus CABG with a high score? Electronic databases were carefully searched for relevant publications. Odds ratios (OR) with 95% confidence intervals (CIs) were calculated and the analysis was carried out by RevMan 5.3. Eleven studies with a total number of 11,037 patients were included. In terms of clinical outcomes, this analysis showed PCI to have significantly favored patients with a low versus a high SYNTAX score. In patients who were re-vascularized by CABG, mortality and major adverse cardiac events were significantly lower with a low SYNTAX score. However, when PCI with a low SYNTAX score was compared with CABG with a high SYNTAX score, no significant difference in mortality and combined death/stroke/myocardial infarction were observed. In conclusion, the SYNTAX score might be considered useful in interventional cardiology. Nevertheless, the fact that it has limitations when compared to newer tools should also not be ignored.

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Prediction of 1-year clinical outcomes using the SYNTAX score in patients with prior heart failure undergoing percutaneous coronary intervention: sub-analysis of the SHINANO registry

Cited by 14 publications

References 30 publications

Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease

Plasma miR-208b and miR-499: Potential Biomarkers for Severity of Coronary Artery Disease

Use of the SYNTAX Score II to predict mortality in interventional cardiology

Percutaneous Coronary Intervention, Coronary Artery Bypass Surgery and the SYNTAX score: A systematic review and meta-analysis

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