2020
DOI: 10.1111/ijfs.14655
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Prediction, molecular docking and identification of novel umami hexapeptides derived from Atlantic cod (Gadus morhua)

Abstract: This paper investigated umami hexapeptides derived from myosin of Atlantic cod (Gadus morhua) using homology modelling, molecular docking, taste evaluation and e-tongue verification. After hydrolysing and prediction in silico, potential bioactivity, toxicity and physicochemical properties of 48 hexapeptides were predicted. Five hexapeptides were selected to dock with the T1R1-T1R3 homology model which was built with SWISS-MODEL. Docking results showed that the five hexapeptides could enter the docking region, … Show more

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Cited by 33 publications
(39 citation statements)
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“…Zhu et al. (2021) selected five hexapeptides to dock with a T1R1/T1R3 homologous model established by the Swiss model, and evaluated the three peptides with the lowest docking energy using electronic tongue and organoleptic evaluation. The results showed that all three peptides were umami, and the umami threshold of peptide INKPEL was 0.25 mg/ml.…”
Section: Screening Of Umami Peptidesmentioning
confidence: 99%
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“…Zhu et al. (2021) selected five hexapeptides to dock with a T1R1/T1R3 homologous model established by the Swiss model, and evaluated the three peptides with the lowest docking energy using electronic tongue and organoleptic evaluation. The results showed that all three peptides were umami, and the umami threshold of peptide INKPEL was 0.25 mg/ml.…”
Section: Screening Of Umami Peptidesmentioning
confidence: 99%
“…and umami peptide. Zhu et al (2021) digested the myosin of Gadus morhua with a virtual enzyme and predicted the potential biological activities of 48 hex-peptides. Yu et al (2021) obtained 747 peptides after virtual enzymolysis of myosin by pepsin, trypsin, and chymotrypsin.…”
Section: Peptides By Computer Simulation Digestionmentioning
confidence: 99%
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