“…In clinical practice, however, precisely discerning between good-and poor-prognosis couples is not always simple. The chances of pregnancy depend on patients' characteristics, such as age, ovarian reserve and cause of infertility, and IVF local policy, such as preimplantation genetic screening, extended culture, and number of transferred embryos; however, a precise personalized estimate remains difficult (van Loendersloot et al, 2014;McLernon et al, 2016b;Sarais et al, 2016). Most importantly, the definition of good-prognosis women, and thus the reliability of RIF diagnosis, should also be adapted to the local context given the elevated inter-centre variability of the effectiveness of IVF (Lintsen et al, 2010).…”