Prediction models and questionnaires developed to predict vitamin D status in adults: a systematic review

Naureen, Ghazala; Sanders, Kerrie M.; Busija, Ljoudmila; Scott, David; Lim, Kok Seong; Talevski, Jason; Connaughton, Catherine; Brennan-Olsen, Sharon

doi:10.1007/s00198-020-05539-1

Cited by 4 publications

(5 citation statements)

References 59 publications

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“…Female sex has also been found as a significant predictor of hypovitaminosis D in previous studies [ 12 , 17 , 19 ], while in most others [ 15 , 34 , 36 , 39 , 40 ], no difference in 25(OH)D concentrations between sexes was found. The association between elevated BMI and lower vitamin D concentration found herein was consistent with the results of all previous reports that have included this variable in their models [ 38 ]. Nevertheless, the magnitude of the effect of these three socio-demographic variables (age, sex, and BMI) on vitamin D concentrations seems limited in a general adult population.…”

Section: Discussionsupporting

confidence: 92%

“…Nevertheless, the magnitude of the effect of these three socio-demographic variables (age, sex, and BMI) on vitamin D concentrations seems limited in a general adult population. Regarding lifestyle factors, the smoking status and sport practice were significant predictors of vitamin D concentration, which is in agreement with previous models that have included them [ 38 ].…”

Section: Discussionsupporting

confidence: 90%

“…Performing an ad hoc study using a specific questionnaire allowed a more reliable and precise collection and measurement of predictive factors. Contrary to most published models [ 38 ], we reported the contribution of individual risk factors in the predictive ability of our model. Individual sun exposure was measured through a number of various questions, making it possible to select the measure that was the easiest to collect among those with equivalent predictive abilities.…”

Section: Discussionmentioning

confidence: 68%

“…Surprisingly, this factor has rarely been included in previously published models [ 19 , 36 ], although the physiological association between skin phototype and vitamin D synthesis has been demonstrated for a long time [ 37 ]. Although sun exposure is an important significant contributor to the predictive ability of the vitamin D status models, individual sun exposure behavior had been precisely measured in only about half of the published models so far [ 38 ]. In addition, individual sun exposure has been measured in various ways regarding intensity, chronology, and surface exposed.…”

Section: Discussionmentioning

confidence: 99%

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Development and Validation of a Predictive Model of Hypovitaminosis D in General Adult Population: SCOPYD Study

et al. 2021

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The worldwide global increase in serum 25-hydroxyvitamin D (25(OH)D) measurements has led some countries to restrict reimbursement for certain clinical situations only. Another approach could consist in providing physicians with screening tools in order to better target blood test prescription. The objective of the SCOPYD study was to identify the best combination of predictors of serum VitD concentration among adults aged 18–70 years. Potential risk factors for VitD deficiency were collected using a comprehensive self-administered questionnaire. A multivariable linear regression was used to build a predictive model of serum 25(OH)D concentration. Among 2488 participants, 1080 (43.4%) had VitD deficiency (<50 nmol/L) and 195 (7.8%) had severe deficiency (<25 nmol/L). The final model included sunlight exposure in the preceding week and during the last holidays, month of blood sampling, age, sex, body mass index, skin phototype, employment, smoking, sport practice, latitude, and VitD supplementation in preceding year. The area under the curve was 0.82 (95% CI (0.78; 0.85)) for severe deficiency. The model predicted severe deficiency with a sensitivity of 77.9% (95% CI (69.1; 85.7)) and a specificity of 68.3% (95% CI (64.8; 71.9)). We identified a set of predictors of severe VitD deficiency that are easy to collect in routine that may help to better target patients for serum 25(OH)D concentration determination.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

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Development and Validation of a Predictive Model of Hypovitaminosis D in General Adult Population: SCOPYD Study

et al. 2021

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“…Errors and potential bias may derive from heterogeneity of patient samples, insufficient sample sizes of comparative groups of patients and controls, short observation periods, or variable follow-up times; in addition, studies may fail to consider the seasonal variability of calcidiol concentrations associated with, inter alia, outdoor sun exposure, the alcohol consumption and smoking habits of HNSCC patients (tobacco smoke may influence vitamin D3 metabolism and function), or fail to relate the degree of vitamin D3 deficiency to the local/regional dissemination of the tumour. Many studies also used non-standardised food frequency questionnaires to assess dietary intake of vitamin D3 [107,108,[289][290][291][292][293]. Furthermore, the studies are often carried out between different populations in heterogeneous ethnic groups with different degrees of exposure to solar ultraviolet B (UVB) radiation and subsequent vitamin D3 (the "sunshine" vitamin) deficiency status.…”

Section: Limitation Of Clinical Studiesmentioning

confidence: 99%

Role of Vitamin D in Head and Neck Cancer—Immune Function, Anti-Tumour Effect, and Its Impact on Patient Prognosis

Starska

2023

Nutrients

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Head and neck squamous cell carcinoma (HNSCC) describes a heterogeneous group of human neoplasms of the head and neck with high rates of morbidity and mortality, constituting about 3% of all cancers and ~1.5% of all cancer deaths. HNSCC constituted the seventh most prevalent human malignancy and the most common human cancer in the world in 2020, according to multi-population observations conducted by the GLOBOCAN group. Since approximately 60–70% of patients present with stage III/IV neoplastic disease, HNSCC is still one of the leading causes of death in cancer patients worldwide, with an overall survival rate that is too low, not exceeding 40–60% of these patients. Despite the application of newer surgical techniques and the implementation of modern combined oncological treatment, the disease often follows a fatal course due to frequent nodal metastases and local neoplastic recurrences. The role of micronutrients in the initiation, development, and progression of HNSCC has been the subject of considerable research. Of particular interest has been vitamin D, the pleiotropic biologically active fat-soluble family of secosteroids (vitamin-D-like steroids), which constitutes a key regulator of bone, calcium, and phosphate homeostasis, as well as carcinogenesis and the further development of various neoplasms. Considerable evidence suggests that vitamin D plays a key role in cellular proliferation, angiogenesis, immunity, and cellular metabolism. A number of basic science, clinical, and epidemiological studies indicate that vitamin D has multidirectional biological effects and influences anti-cancer intracellular mechanisms and cancer risk, and that vitamin D dietary supplements have various prophylactic benefits. In the 20th century, it was reported that vitamin D may play various roles in the protection and regulation of normal cellular phenotypes and in cancer prevention and adjunctive therapy in various human neoplasms, including HNSCC, by regulating a number of intracellular mechanisms, including control of tumour cell expansion and differentiation, apoptosis, intercellular interactions, angio- and lymphogenesis, immune function, and tumour invasion. These regulatory properties mainly occur indirectly via epigenetic and transcriptional changes regulating the function of transcription factors, chromatin modifiers, non-coding RNA (ncRNAs), and microRNAs (miRs) through protein-protein interactions and signalling pathways. In this way, calcitriol enhances intercellular communication in cancer biology, restores the connection with the extracellular matrix, and promotes the epithelial phenotype; it thus counteracts the tumour-associated detachment from the extracellular matrix and inhibits the formation of metastases. Furthermore, the confirmation that the vitamin D receptor (VDR) is present in many human tissues confirmed the physiopathological significance of vitamin D in various human tumours. Recent studies indicate quantitative associations between exposure to vitamin D and the incidence of HNC, i.e., cancer risk assessment included circulating calcidiol plasma/serum concentrations, vitamin D intake, the presence of the VDR gene polymorphism, and genes involved in the vitamin D metabolism pathway. Moreover, the chemopreventive efficacy of vitamin D in precancerous lesions of the head and neck and their role as predictors of mortality, survival, and recurrence of head and neck cancer are also widely discussed. As such, it may be considered a promising potential anti-cancer agent for developing innovative methods of targeted therapy. The proposed review discusses in detail the mechanisms regulating the relationship between vitamin D and HNSCC. It also provides an overview of the current literature, including key opinion-forming systematic reviews as well as epidemiological, prospective, longitudinal, cross-sectional, and interventional studies based on in vitro and animal models of HNSCC, all of which are accessible via the PubMed/Medline/EMBASE/Cochrane Library databases. This article presents the data in line with increasing clinical credibility.

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Predicting deseasonalised serum 25 hydroxy vitamin D concentrations in the D-Health Trial: An analysis using boosted regression trees

Waterhouse

Baxter

Romero

et al. 2021

Contemporary Clinical Trials

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Prediction models and questionnaires developed to predict vitamin D status in adults: a systematic review

Cited by 4 publications

References 59 publications

Development and Validation of a Predictive Model of Hypovitaminosis D in General Adult Population: SCOPYD Study

Development and Validation of a Predictive Model of Hypovitaminosis D in General Adult Population: SCOPYD Study

Role of Vitamin D in Head and Neck Cancer—Immune Function, Anti-Tumour Effect, and Its Impact on Patient Prognosis

Predicting deseasonalised serum 25 hydroxy vitamin D concentrations in the D-Health Trial: An analysis using boosted regression trees

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