Prediction model for live birth in ICSI using testicular extracted sperm

Meijerink, A.M.; Cissen, M.; Mochtar, Monique H.; Fleischer, Kathrin; Thoonen, I.J.M.; Melker, Annemieke A. de; Meißner, Andreas; Repping, Sjoerd; Braat, D.D.M.; Wely, Madelon van; Ramos, Liliana

doi:10.1093/humrep/dew146

Cited by 30 publications

(28 citation statements)

References 31 publications

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“…There are various factors known to influence pregnancy outcomes following TESE-ICSI cycles, such as paternal age, maternal age, male testosterone, sperm motility, and/or type of azoospermia [12][13][14]. Among these factors, the motility of spermatozoa is emphasized as an important predictive factor for successful fertilization by ICSI [15].…”

Section: Discussionmentioning

confidence: 99%

Effect of in vitro testicular spermatozoa culture on pregnancy outcomes: an experience at a single university hospital

Lee

Yoo²,

Lee

et al. 2021

Yeungnam Univ J Med

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Section: Discussionmentioning

confidence: 99%

Effect of in vitro testicular spermatozoa culture on pregnancy outcomes: an experience at a single university hospital

Lee

Yoo²,

Lee

et al. 2021

Yeungnam Univ J Med

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“…Thus far, three studies have assessed the predictive factors of achieving pregnancy after TESE [242526]. Although predictive models for sperm retrieval or pregnancy outcome after TESE have been designed to counsel patients with NOA about their chances of successfully obtaining spermatozoa, they have not generally been implemented in clinical practice [27].…”

Section: Discussionmentioning

confidence: 99%

Factors influencing sperm retrieval following testicular sperm extraction in nonobstructive azoospermia patients

Salehi

Derakhshan-Horeh

Nadeali

et al. 2017

Clin Exp Reprod Med

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ObjectiveAzoospermia owing to testicular disorders is the most severe manifestation of male infertility. The main concern for patients with nonobstructive azoospermia (NOA) is the probability of successful sperm retrieval following testicular sperm extraction (TESE). Therefore, the goal of this study was to determine predictive factors correlated with sperm retrieval.MethodsWe assessed the testicular histopathological patterns, the choice of TESE surgical procedure, hormone levels, and chromosomal abnormalities in patients with NOA (n=170). The histopathology specimens were analyzed based on the histopathological patterns of hypospermatogenesis, maturation arrest, and Sertoli cell-only syndrome.ResultsThe mean rate of sperm retrieval was 48.8%. The rate of sperm retrieval was significantly higher in the hypospermatogenesis group than in the other groups (p<0.001). There was a positive correlation between micro-TESE (vs. conventional TESE) and the sperm retrieval rate (odds ratio, 8.077; p<0.01). A logistic regression model demonstrated that high levels of follicle-stimulating hormone (FSH) and small testicular volume were significantly associated with lower chances of successful sperm retrieval.ConclusionSome parameters, including testicular histopathology patterns, FSH levels, testicular volume, and method of TESE surgery, may be able to predict the chances of obtaining spermatozoa in patients with NOA. However, despite the efficiency of some predictive models, the hope of retrieving any functioning spermatozoa may be sufficient to disregard predictive factors of the success of intracytoplasmic sperm injection in these patients.

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“…TESE is now routinely offered worldwide to men with azoospermia with a success rate of retrieval of spermatozoa of ~50% for men with NOA and Klinefelter syndrome, and can go up to 100% for men with OA ( Chan and Schlegel, 2000 ; Cissen et al , 2016 ; Corona et al , 2017 ). The described live birth rates for ICSI with testicular retrieved spermatozoa vary from 10 to 45% per cycle for all types of azoospermia ( Bocca et al , 2017 ; Corona et al , 2017 ; Esteves and Agarwal, 2013 ; Meijerink et al , 2016 ).…”

Section: Introductionmentioning

confidence: 99%

The risk of TESE-induced hypogonadism: a systematic review and meta-analysis

Eliveld

Wely

Meißner

et al. 2018

Human Reproduction Update

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BACKGROUNDTesticular sperm extraction (TESE) is a surgical procedure to retrieve spermatozoa from the testes of men with azoospermia to help them achieve biological parenthood. Although effective, the surgical procedure is not without complications and haematoma, devascularization, inflammation and a decrease in testosterone levels have been described as such. The prevalence and duration of hypogonadism and associated symptoms after TESE have not been studied systematically.OBJECTIVE AND RATIONALEIn this systematic review we addressed the following research questions: Are serum testosterone levels decreased after TESE and, if so, do these levels recover over time? What is the prevalence of symptoms and signs related to hypogonadism after TESE and are they related to testosterone levels?SEARCH METHODSWe searched the databases Pubmed and Embase from 1 January 1993 to 26 June 2017. We combined subject headings with terms in title and/or abstract for participants, intervention and outcomes. We included all studies that reported on TESE, regardless of the specific technique used, that measured testosterone and/or LH, and/or had information on signs or symptoms related to hypogonadism as defined by hypogonadism guidelines. An additional inclusion criterion was that studies described these measurements both before and after TESE. The quality of the included studies was assessed using the Risk Of Bias In Non-randomized Studies—of Interventions tool.OUTCOMESWe identified 15 studies reporting on total testosterone levels of which five studies also reported on testicular volume and one study on erectile dysfunction. Men with Klinefelter syndrome and men with non-obstructive azoospermia had the strongest decrease in total testosterone levels 6 months after TESE, with a mean decrease of 4.1 and 2.7 nmol/l, respectively, which recovered again to baseline levels 26 and 18 months after TESE, respectively. At 6 months after TESE, some studies reported serum total testosterone concentrations below a cut-off value of 12 nmol/l, where symptoms and signs related to hypogonadism may appear. Furthermore, an increased prevalence of erectile dysfunction related to decreased total testosterone levels 6 months after TESE was reported. Also, in some men a decrease in testicular volume was reported. However, it is not clear if this is related to low testosterone levels.WIDER IMPLICATIONSThe transient, but statistically significant, decrease in total testosterone levels indicates that men are at risk of developing a temporary hypogonadism after TESE, but there is insufficient evidence for whether patients actually experience clinical symptoms in case of decreased serum testosterone levels. To be able to properly counsel TESE patients, more large-scale monitoring on signs and symptoms of hypogonadism, in combination with testosterone measurements, needs to be performed in men undergoing TESE.

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Prediction model for live birth in ICSI using testicular extracted sperm

Abstract: Not applicable.

Cited by 30 publications

References 31 publications

Effect of in vitro testicular spermatozoa culture on pregnancy outcomes: an experience at a single university hospital

Effect of in vitro testicular spermatozoa culture on pregnancy outcomes: an experience at a single university hospital

Factors influencing sperm retrieval following testicular sperm extraction in nonobstructive azoospermia patients

The risk of TESE-induced hypogonadism: a systematic review and meta-analysis

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