Prediction model for hearing outcome in patients with idiopathic sudden sensorineural hearing loss

Abstract

The aim of this study is to develop a regression model for predicting hearing outcome in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). A total of 174 consecutive patients with ISSNHL (average of the hearing levels at 250, 500, 1,000, 2,000, and 4,000 Hz was ≥40 dB; time from onset to treatment was ≤30 days) were retrospectively analyzed. They received steroid administration (400 mg/day of hydrocortisone sodium succinate followed by tapered doses) in combination with hyperbaric oxygen therapy. The hearing improvement rate compared to the unaffected contralateral ear was calculated. Correlations between the hearing improvement rate and four prognostic factors (patient's age, days from onset to treatment, initial hearing level, and the presence of vertigo) were examined by simple and multiple regression analyses. In the simple regression analysis, significant correlations were observed between the hearing improvement rate and all four prognostic factors. In the multiple regression analysis, the correlation was significant for patient's age, days from onset to treatment, and the presence of vertigo with partial correlation coefficients of -0.221, -0.324, and -0.329, respectively, but was not significant for the initial hearing level. We subsequently formulated a multiple regression equation for predicting the hearing improvement rate. The multiple correlation coefficient was 0.495 with a p value of 1.42 × 10(-9). Using this regression model, the hearing improvement rate is still difficult to predict with 95% probability, but is predictable with 70% probability.

Predictors of hearing recovery in patients with severe sudden sensorineural hearing loss

“…The association between the subjective perception of vertigo and worse outcome could be demonstrated by several studies [32, 33, 36–45]. But, the association between objective calorimetric tests and hearing outcome was only investigated by a few [29, 31, 32].…”

Endolymphatic space imaging in idiopathic sudden sensorineural hearing loss with vertigo

“…3D‐FLAIR MRI post‐transtympanic gadolinium injection has contributed to the detection of endolymphatic hydrops in patients with ISNHL and vertigo who had not previously been definitely diagnosed in vivo. Vertigo is considered a factor that compromises the efficiency of treatment in ISNHL 9. In our study, the results of the 3D‐FLAIR MRI after intratympanic gadolinium injection indicates an underlying association between endolymphatic hydrops and vertigo.…”

Effects and Prognostic Factors of Acupuncture Treatment for Idiopathic Sudden Sensorineural Hearing Loss

“…Because of the multifactorial etiopathology, a number or different regimens have been used as therapy, including vasodilators, anticoagulants, corticosteroids, vitamins, plasma expander, histamine, antiviral agents, batroxobin, contrast media, stellate ganglion block, hyperbaric oxygen, and carbogen (Suzuki H et al, 2011).…”

“…The presence of vertigo is one of important prognostic factors for recovery of hearing loss which many studies recommended (Kang D & Wan L, 2005;Suzuki H et al, 2011;Cvorović L et al, 2008). Some studies reported that BPPV in patients with SSHL, representing definitive vestibular damage, was closely related to poor prognosis (Lee NH & Ban JH, 2010).…”

“…Many studies regarded the severity of hearing loss is one of the important prognostic factors for improvement of ISSHL (Byl FM., 1984;Fetterman BL et al, 1999;Psifidis AD et al, 2006;Cvorovic L et al, 2008;Ceylan A et al, 2007) However, the standard of severity which could affect the prognosis, was different in each study Moreover, some studies have reported that the initial hearing level had no statistical point on prognosis (Suzuki H et al, 2011;Wang L et al, 2009). In our study, there was no difference in severity of hearing loss between improvement and no improvement groups.…”