Prediction for 2-Year Vision Outcomes Using Early Morphologic and Functional Responses in the Comparison of Age-related Macular Degeneration Treatments Trials

Xue, Katie; Hua, Peiying; Maguire, Maureen G.; Daniel, Ebenezer; Jaffe, Glenn J.; Grunwald, Juan E.; Ying, Gui‐Shuang; Williams, David F.; Beardsley, Sara; Bennett, Steven R.; Cantrill, Herbert L.; Chan-Tram, Carmen; Cheshier, Holly; Damato, Kathyrn; Davies, John B.; Dev, Sundeep; Enloe, Julianne; Follano, Gennaro; Gilbert, Peggy; Johnson, Jill; Jones, Tori; Mayleben, Lisa; Mittra, Robert A.; Moos, Martha; Neist, Ryan; Oestreich, Neal; Quiram, Polly A.; Ramsay, Robert C.; Ryan, Edwin H.; Schindeldecker, Stephanie; Snater, John; Steele, Trenise; Selders, Dwight; Tonsfeldt, Jessica; Valardi, Shelly; Fish, Gary E.; Aguado, Hank; Arceneaux, Sally; Arnwine, Jean; Bell, Kim; Boleman, Bob; Bradley, Patricia; Callanan, David; Coors, Lori E.; Creighton, Jodi; Crew, Timothy; Cummings, Kimberly; Dock, Christopher; Duignan, Karen; Fuller, Dwain G.; Gray, Keith; Hendrix, Betsy; Hesse, Nicholas; Jaramillo, Diana; Jost, Bradley F.; Lash, Sandy; Lonsdale, Laura; Mackens, Michael; Mutz, Karin; Potts, Michael; Sanchez, Brenda; Snyder, William B.; Solley, Wayne A.; Tarter, Carrie; Wang, Robert; Williams, Patrick D.; Perkins, Stephen L.; Anderson, Nicholas; Arnold, Ann; Blais, Paul; Googe, Joseph M.; Higdon, Tina T.; Hunt, Cecile; Johnson, Mary A.; Miller, James M.; Moore, Misty; Morris, Charity K.; Morris, Christopher; Oelrich, Sarah; Oliver, Kristina; Seitz, Vicky; Whetstone, Jerry; Doft, Bernard H.; Bedel, Jay; Bergren, Robert L.; Borthwick, Ann; Conrad, P. 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doi:10.1016/j.oret.2023.02.008

Cited by 3 publications

(1 citation statement)

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“…Very short-term response to an anti-VEGF treatment has been advocated as an indicator of long-term outcome, since a patient who does not show even a small degree of improvement during the loading phase will likely continue not to respond to that treatment in the future. Several studies indicate that the long-term response can be predicted even after the first injections in some cases [ 15 , 31 – 33 ].…”

Section: Discussionmentioning

confidence: 99%

Real-World Outcomes of a Loading Phase with Intravitreal Faricimab in Neovascular Age-Related Macular Degeneration (n-AMD) and Diabetic Macular Edema (DME)

Giancipoli,

Guglielmi,

Bux

et al. 2024

Ophthalmol Ther

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Introduction The aims of this work were to evaluate the real-world efficacy and safety of a loading dose of intravitreal faricimab in eyes with active neovascular age-related macular degeneration (n-AMD) or diabetic macular edema (DME) and to analyze the treatment outcome in relation to specific biomarkers. Methods Patients with active n-AMD or DME, treated with four monthly intravitreal injections of faricimab, were enrolled in this retrospective, uncontrolled study. Best-corrected visual acuity (BCVA), central subfield thickness (CST), presence of retinal fluid (RF) on optical coherence tomography (OCT), and adverse events were assessed at baseline and at weeks 4, 8, 12, and 16. Predefined biomarkers were evaluated at baseline (BL) and at last visit. Results Sixteen eyes of 15 patients with n-AMD (n-AMD group) and 15 eyes of 12 patients with DME (DME group) were included. Mean (± standard deviation) logarithm of minimum angle of resolution (logMAR) BL BCVA changed from 0.68 (± 0.43) to 0.53 (± 0.36; P = 0.13) and from 0.51 (± 0.34) to 0.32 (± 0.24; P : 0.048) at week 16 in n-AMD and DME group, respectively. A statistically significant mean CST reduction was reported in both groups at last visit (n-AMD: − 166.5 μm; P = 0.0009/DME: − 110.8 μm; P = 0.0086). Seventy-five and 33% of eyes with n-AMD and DME respectively achieved complete RF resolution at last visit. Subfoveal inner and outer retinal damage correlated with a lower final BCVA in n-AMD group. The presence of large (> 100 μm) juxtafoveal microaneurysms (MAs) was significantly correlated with a higher chance of residual fluid in eyes with DME. Conclusions Both n-AMD and DME groups achieved satisfactory anatomical results after a loading-dose of intravitreal faricimab. BCVA improvement might be hampered by pre-existing retinal damage in eyes with n-AMD. Large, juxtafoveal MAs might represent a hallmark of a slower anatomical response to the treatment in eyes with DME.

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Section: Discussionmentioning

confidence: 99%