Prediction error and somatosensory insula activation in women recovered from anorexia nervosa

Frank, Guido; Collier, Shaleise; Shott, Megan E.; O’Reilly, Randall C.

doi:10.1503/jpn.150103

Cited by 39 publications

(41 citation statements)

References 49 publications

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“…The regions that showed altered brain responses in the present study (i.e., the rostral ACC and posterior insula) have been implicated in AN pathology . Insular dysfunction has specifically been reported . Furthermore, studies have reported insular function differences among AN subtypes.…”

Section: Discussionsupporting

confidence: 46%

Differences in neural responses to reward and punishment processing between anorexia nervosa subtypes: An fMRI study

Murao

Sugihara

Isobe

et al. 2017

Psychiatry Clin Neurosci

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AN-bp patients showed altered neural responses to punishment in brain regions implicated in emotional arousal. Our findings suggest that individuals with AN-bp are more sensitive to potential punishment than individuals with AN-r and healthy individuals at the neural level. The present study provides preliminary evidence that there are neurobiological differences between AN subtypes with regard to the reward system, especially punishment processing.

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Section: Discussionsupporting

confidence: 46%

Differences in neural responses to reward and punishment processing between anorexia nervosa subtypes: An fMRI study

Murao

Sugihara

Isobe

et al. 2017

Psychiatry Clin Neurosci

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show abstract

“…Following surgery, we found decreased fALFF within the insula, putamen thalamus, caudate, cingulate cortex (including the anterior cingulate) and the middle and inferior frontal gyri. In terms of the functionality of these areas, the insula specifically has been implicated in a variety of experiments involving obesity (as shown via meta‐analysis) (Brooks et al ., ), as well as in eating disorders such as anorexia nervosa (Frank et al ., , ) and bulimia nervosa, where insular size differences distinguished the two diseases (Frank et al ., ). Furthermore, the insula is suggested to be involved in self‐referential processing within eating disorders (Esposito et al ., ) and obesity (Dietrich et al ., ).…”

Section: Discussionmentioning

confidence: 99%

A resting‐state fMRI study of obese females between pre‐ and postprandial states before and after bariatric surgery

Wiemerslage

Zhou

Olivo

et al. 2016

Eur J of Neuroscience

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Past studies utilizing resting-state functional MRI (rsfMRI), have shown that obese humans exhibit altered activity in brain areas related to reward compared to normal-weight controls. However, to what extent bariatric surgery-induced weight loss alters resting-state brain activity in obese humans is less well-studied. Thus, we measured the fractional amplitude of low-frequency fluctuations from eyes-closed, rsfMRI in obese females (n = 11, mean age = 42 years, mean BMI = 41 kg/m 2 ) in both a pre-and postprandial state at two time points: four weeks before, and four weeks after bariatric surgery. Several brain areas showed altered resting-state activity following bariatric surgery, including the putamen, insula, cingulate, thalamus and frontal regions. Activity augmented by surgery was also dependent on prandial state. For example, in the fasted state, activity in the middle frontal and pre-and postcentral gyri was found to be decreased after surgery. In the sated state, activity within the insula was increased before, but not after surgery. Collectively, our results suggest that resting-state neural functions are rapidly affected following bariatric surgery and the associated weight loss and change in diet.

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“…Learning depends on associations between anticipated and actual outcomes (Schultz et al 1997), and differences between the expected and observed interoceptive state, or prediction errors, may promote avoidance learning and behavior (Paulus & Stein 2006). Women with AN have difficulty distinguishing actual from anticipated sensations (Khalsa et al 2015), and women remitted from AN (RAN) show altered neural activation during anticipation and receipt of sucrose tastes (Frank et al 2016; Oberndorfer et al 2013b). Return to homeostasis after state changes may also be impaired in AN: Interoceptive accuracy in AN decreases after eating (Khalsa et al 2015), and habituation to fullness is protracted (Zucker et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Altered interoceptive activation before, during, and after aversive breathing load in women remitted from anorexia nervosa

et al. 2017

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Background The neural mechanisms of anorexia nervosa (AN), a severe and chronic psychiatric illness, are still poorly understood. Altered body state processing, or interoception, has been documented in AN, and disturbances in aversive interoception may contribute to distorted body perception, extreme dietary restriction, and anxiety. As prior data implicate a potential mismatch between interoceptive expectation and experience in AN, we examined whether AN is associated with altered brain activation before, during, and after an unpleasant interoceptive state change. Methods Adult women remitted from AN (RAN; n = 17) and healthy control women (CW; n = 25) underwent functional magnetic resonance imaging during an inspiratory breathing load paradigm. Results During stimulus anticipation, the RAN group, relative to CW, showed reduced activation in right mid-insula. In contrast, during the aversive breathing load, the RAN group showed increased activation compared with CW in striatum and cingulate and prefrontal cortices. The RAN group also showed increased activation in prefrontal cortices, bilateral insula, striatum, and amygdala after stimulus offset. Time course analyses indicated that RAN responses in interoceptive processing regions during breathing load increased more steeply than those of CW. Exploratory analyses revealed that hyperactivation during and after breathing load was associated with markers of past AN severity. Conclusions Anticipatory deactivation with a subsequent exaggerated brain response during and after an aversive body state may contribute to difficulty predicting and adapting to internal state fluctuation. Because eating changes our interoceptive state, restriction may be one method of avoiding aversive, unpredictable internal change in AN.

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Prediction error and somatosensory insula activation in women recovered from anorexia nervosa

Cited by 39 publications

References 49 publications

Differences in neural responses to reward and punishment processing between anorexia nervosa subtypes: An fMRI study

Differences in neural responses to reward and punishment processing between anorexia nervosa subtypes: An fMRI study

A resting‐state fMRI study of obese females between pre‐ and postprandial states before and after bariatric surgery

Altered interoceptive activation before, during, and after aversive breathing load in women remitted from anorexia nervosa

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