Prediction and Prevention of Liver Failure After Major Liver Primary and Metastatic Tumors Resection

Каприн, А. Д.; Сидоров, Д. В.; Рубцова, Н. А.; Леонтьев, А. В.; Ложкин, М. В.; Петров, Л. О.; Grishin, N. A.; Лазутина, Т. Н.; Pylova, I. V.; Исаева, А. Г.

doi:10.17709/2409-2231-2016-3-2-2

Cited by 3 publications

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“…Accordingly, in the contemporary literature, cases of ischemia-reperfusion damage to the liver are described, which is often observed when performing operations in the hepatobiliary region using the Pringle maneuver [1]. The latter presumes temporary compression of the hepatoduodenal ligament blood vessels [2], followed by dissection of the liver parenchyma within the ischemic zone (5-10 mm from the demarcation line). This tactic is used during the surgeries, such as liver resection, and in the course of organ transplantation.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity Of Rat Liver With A Low Resistance To Hypoxia After Systemic Ischemia Reperfusion

et al. 2021

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Objective — To assess the antioxidant activity of rat liver after systemic ischemia reperfusion (IRP). Material and Methods — The study was conducted on 70 male rats. For all animals of the treatment group (n=35) under ether anesthesia, we were stopping stopping systemic circulation for five minutes. After that, the animals were given an external cardiac massage and artificial lung ventilation. We did not perform circulatory arrest after ether anesthesia in animals of the control group (n=35). In all animals, we were measuring the levels of serum hormones (corticosterone, aldosterone), the content of glucocorticoid and mineralocorticoid receptors in liver homogenates, and the activity of enzymes of the antioxidant system (superoxide dismutase and catalase). We were making control measurements on days 1, 3, 5, 7, 14, 21, and 35 after the simulated IRP. Results — On day 1 after simulation of IRP development, the levels of cortisol and aldosterone in the serum of treatment group rats were significantly higher, by 14.3% and 33.5%, respectively, compared with the control group. In response to stress (IRP), we observed the highest concentration of cortisol in the blood of treatment group rats on day 3 (p=0.0002), which decreased afterwards. On day 1 after IRP, there was a reduction in the activity of superoxide dismutase and catalase in treatment group rats, by 50.3% and by 29%, respectively (p<0.0001). The lowest antioxidant activity in the rat liver after IRP was observed on days 3-7. Conclusion — Systemic IRP is associated with pronounced changes in the dynamics of corticosteroid receptors in the liver, which leads to a reduction in the activity of key antioxidant enzymes.

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Section: Introductionmentioning

confidence: 99%

Antioxidant Activity Of Rat Liver With A Low Resistance To Hypoxia After Systemic Ischemia Reperfusion

et al. 2021

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“…Выполнение анатомических (реже -атипичных) резекций печени признано золотым стандартом лечения пациентов с первичным и метастатическим раком печени абсолютным большинством отечественных и зарубежных авторов [1]. При этом у пациентов со сниженными показателями функционального резерва печени, недостаточным объемом остающейся паренхимы данные операции связаны с высоким риском развития пострезекционной острой печеночной недостаточности [1,2]. Основным помощником в лечении больных, которым невыполнимо радикальное хирургическое лечение, остается использование различных видов абляции.…”

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First Russian Experience of Using the Integrated System of Laser Thermoablation Therapy in the Treatment of Metastatic Liver Cancer

Сидоров¹,

Stepanov²,

Ложкин³

et al. 2017

Issled. prakt. med. (Print)

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Extensive liver resections are the main method of treatment of patients with primary and metastatic liver cancer, which allows the noticeable prolongation of life. In patients with a reduced functional reserve of the liver or a missing volume of the remaining liver parenchyma, these interventions become impossible because of the increased risk of postresectional acute hepatic insufficiency. One of the most modern and promising ways to overcome this obstacle is the use of minimally invasive methods of tumor destruction. This article presents two observations of the clinical application of the laser ablator “Echolaser X4”: open laser ablation of the metastatic focus with subsequent atypical liver resection and percutaneous laser ablation of the metastasis of the neuroendocrine tumor into the liver. The presented experience testifies to the justification of using laser destruction of metastatic malignant liver tumors and demonstrates the possibilities of laser thermoablation therapy in patients who can not perform radical surgical treatment.

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Staged Surgical Treatment for Patients with Liver Tumors and Optimal Method of Vicarious Hypertrophy of the Liver Remnant: Literature Review

Pelts,

Tropin,

Pavlenko

et al. 2023

Kreativnaâ hirurgiâ i onkologiâ

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The evolution of hepatic surgery at the present stage of medical development requires specialists to develop patient-oriented rational surgical tactics and use modern methods for the diagnosis and prediction of post-resection liver failure in the surgical treatment of liver tumors by resection, thereby forming approaches that reduce the risks of severe postoperative complications associated with insufficient liver remnants remaining after extensive resection. The paper reviews the problematic issues of diagnosis and treatment of liver tumors, as well as provides current views on the relevance of timely prevention of post-resection liver failure. The study considers methods for assessing the risks of complications and adverse outcome when planning and performing extensive liver resections, defines the concept of post-resection liver failure, and highlights the main mechanisms of vicarious hypertrophy. The paper examines the most commonly used methods for vicarious hypertrophy of the parenchyma remaining after extensive liver resection, their advantages, and disadvantages. The main possible causes of failures in developing a strategy for two-stage liver resections are analyzed. A critical analysis of available contemporary literature enabled the authors of the paper to identify possible ways to further improve the results of extensive liver resections.

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Prediction and Prevention of Liver Failure After Major Liver Primary and Metastatic Tumors Resection

Cited by 3 publications

References 0 publications

Antioxidant Activity Of Rat Liver With A Low Resistance To Hypoxia After Systemic Ischemia Reperfusion

Antioxidant Activity Of Rat Liver With A Low Resistance To Hypoxia After Systemic Ischemia Reperfusion

First Russian Experience of Using the Integrated System of Laser Thermoablation Therapy in the Treatment of Metastatic Liver Cancer

Staged Surgical Treatment for Patients with Liver Tumors and Optimal Method of Vicarious Hypertrophy of the Liver Remnant: Literature Review

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