Predicting weight gain in patients with cystic fibrosis on triple combination modulator
Kelly L. Stewart,
Rhonda Szczesniak,
Theodore G. Liou
Abstract:BackgroundCystic fibrosis (CF) is caused by CF transmembrane conductance regulator (CFTR) gene mutations producing dysfunctional CFTR proteins leading to progressive clinical disease. Elexacaftor‐tezacaftor‐ivacaftor (ETI) remarkably improves lung disease but is associated with substantial weight gain.Study Design and MethodsWe performed a single‐center longitudinal study predicting 6‐month weight gain after ETI initiation. We used linear mixed effects modeling (LME) to determine association of ETI treatment w… Show more
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