Predicting total knee arthroplasty from ultrasonography using machine learning

Tiulpin, Aleksei; Saarakkala, Simo; Mathiessen, Alexander; Hammer, Hilde Berner; Furnes, Ove; Nordsletten, Lars; Englund, Martin; Magnusson, Karin

doi:10.1016/j.ocarto.2022.100319

Cited by 7 publications

(6 citation statements)

References 37 publications

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“…[ 46 ] The assessment of femoral articular thickness has been validated against pain scores, the WOMAC scale,[ 47 , 48 ] and muscle strength. [ 49 ] The medial compartment cartilage thickness loss was found to be associated with both concurrent and subsequent radiographic progression and with concurrent symptomatic progression,[ 50 ] with recent data suggesting that ultrasonographic examination of the knee and a machine learning method may provide added value to basic clinical and demographic descriptors in predicting total knee replacement in the future,[ 51 ] both contributing significantly to the process of establishing cartilage thickness as a biomarker of clinically relevant progression of knee OA.…”

Section: Discussionmentioning

confidence: 99%

The short-term effect of glucosamine-sulfate, nonanimal chondroitin-sulfate, and S-adenosylmethionine combination on ultrasonography findings, inflammation, pain, and functionality in patients with knee osteoarthritis: A pilot, double-blind, randomized, placebo-controlled clinical trial

Veličković1†,

Pavlov Dolijanović,

Stojanović

et al. 2023

Arch Rheumatol

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Objectives: This study aimed to investigate the efficacy of glucosamine-sulfate (GS), nonanimal chondroitin-sulfate (naCS), and S-adenosylmethionine (SAMe) combination on ultrasound findings, inflammation, pain, and functionality in knee osteoarthritis. Patients and methods: In the prospective, randomized, double-blind, placebo-controlled pilot study conducted between August 2019 and November 2019, 120 participants (28 males, 92 females; mean age: 66.4±7.9 years; range, 42.4 to 74.5 years) were randomized at a 1:1:1 ratio to the placebo group, the first experimental group (a combination of GS, naCS, and SAMe was administered to the experimental groups. The first experimental group received 375 mg of GS, 300 mg of naCS, and 100 mg of SAMe, whereas the second experimental group received 750 mg of GS, 600 mg of naCS, and 200 mg of SAMe). Laboratory (erythrocyte sedimentation rate, C-reactive protein, tumor necrosis factor alpha, interleukin [IL]-1β, IL-6, IL-17), clinical (Visual Analog Scale [VAS], short form health survey [SF-36], the Western Ontario and McMaster Universities Arthritis Index [WOMAC], and the Tegner Lysholm Knee Scoring Scale [TLKS]), and musculoskeletal ultrasound (MSUS) assessments were performed at baseline and after three and six months. Results: A minor increase was observed in the second experimental group after six months using ultrasonography to evaluate articular cartilage thickness (p<0.05). The investigational product's superiority in reducing osteoarthritis ultrasonographic findings was not proven. A moderately negative association was found between cartilage thickness and VAS scores at baseline (ρ=-0.36, p<0.01), while the presence of massive osteophytes on MSUS showed a low to moderate association with all clinical outcomes. There was no difference in the delta changes between groups for the VAS, TLKS, WOMAC, and SF-36. The only serum inflammatory marker outside the reference range was IL-1β, but no significant changes were observed after six months. Conclusion: According to the results of our investigation, treatment for knee osteoarthritis should be evaluated using more objective outcomes. The most important conclusion of our study is that IP may result in a slight increase in articular cartilage thickness, which was associated with a decrease in pain intensity at baseline. Clarification of the potential influence of this combination on radiographic progression and laboratory markers of inflammation requires further exploration.

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Section: Discussionmentioning

confidence: 99%

The short-term effect of glucosamine-sulfate, nonanimal chondroitin-sulfate, and S-adenosylmethionine combination on ultrasonography findings, inflammation, pain, and functionality in patients with knee osteoarthritis: A pilot, double-blind, randomized, placebo-controlled clinical trial

Veličković1†,

Pavlov Dolijanović,

Stojanović

et al. 2023

Arch Rheumatol

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“…Ultrasonography is a non-invasive diagnostic tool that uses high-frequency sound waves to produce real-time images of the knee joints and other internal structures within the body, including muscles, tendons, blood vessels, and organs [ 33 ]. It enables immediate evaluation of soft tissues, such as cartilage and menisci [ 34 , 35 ]. Differently from radiographs, it facilitates a 3D evaluation of the joint without ionizing radiation exposure [ 36 ].…”

Section: Imaging Of Knee Osteoarthritismentioning

confidence: 99%

Artificial intelligence in knee osteoarthritis: A comprehensive review for 2022

Özkan

Deniz

2023

Osteoarthritis Imaging

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“…Some studies have predicted KR using demographics and clinical data, highlighting the importance of the Kellgren-Lawrence grading (KLG) in disease prognosis [ 4 , 5 ]. With advancements in medical imaging analysis technology, several studies directly analysed medical images, primarily Magnetic Resonance Imaging (MRI) and X-ray, for KR prediction [ [6] , [7] , [8] , [9] , [10] , [11] , [12] ]. One study analysed the shape of MRI femur bone from the Osteoarthritis Initiative (OAI) dataset.…”

Section: Introductionmentioning

confidence: 99%

Radiomics analysis of patellofemoral joint improves knee replacement risk prediction: Data from the Multicenter Osteoarthritis Study (MOST)

Zhang,

Jiang,

Chan

et al. 2024

Osteoarthritis and Cartilage Open

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Predicting total knee arthroplasty from ultrasonography using machine learning

Cited by 7 publications

References 37 publications

The short-term effect of glucosamine-sulfate, nonanimal chondroitin-sulfate, and S-adenosylmethionine combination on ultrasonography findings, inflammation, pain, and functionality in patients with knee osteoarthritis: A pilot, double-blind, randomized, placebo-controlled clinical trial

The short-term effect of glucosamine-sulfate, nonanimal chondroitin-sulfate, and S-adenosylmethionine combination on ultrasonography findings, inflammation, pain, and functionality in patients with knee osteoarthritis: A pilot, double-blind, randomized, placebo-controlled clinical trial

Artificial intelligence in knee osteoarthritis: A comprehensive review for 2022

Radiomics analysis of patellofemoral joint improves knee replacement risk prediction: Data from the Multicenter Osteoarthritis Study (MOST)

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