Predicting the risk of parafoveal scotoma in myopic normal tension glaucoma: role of optic disc tilt and rotation

Sung, Mi Sun; Heo, Hwan; Ji, Yong‐Sok; Park, S W

doi:10.1038/eye.2017.33

Cited by 15 publications

(21 citation statements)

References 40 publications

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“…The results of the current study agree with these previous reports. [20][21][22] In the current study, both the Drasdo and the Sjöstrand models resulted in better structure-function relationships than those achieved by the no-displacement model, particularly around the fovea. Ohkubo et al 5 compared the pointwise structure-function relationships of patients with glaucoma (average MD value of HFA 10-2 test: -5.49 ± 5.74 dB; range, -20.25 to +2.94 dB) in nonlong AL eyes (more than -6 diopters of myopia) using the Sjöstrand model.…”

Section: Discussionmentioning

confidence: 91%

“…Araie et al 21 reported that the power of myopia was significantly correlated with depression in the inferior VF of 10-2 test locations in glaucoma eyes. Sung et al 22 reported that among 99 eyes with early myopic normal tension glaucoma, 42 (42.42%) showed scotoma within 10 degrees. As implied by these studies, VF sensitivity tends to decrease as myopia increases, and myopic glaucoma eyes tend to show inferior and parafoveal VF defects.…”

Section: Discussionmentioning

confidence: 99%

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Comparing Structure-Function Relationships Based on Drasdo's and Sjöstrand's Retinal Ganglion Cell Displacement Models

Hirasawa

Fujino

Yanagisawa

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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To compare structure-function relationships based on the Drasdo and Sjöstrand retinal ganglion cell displacement models. METHODS. Single eyes from 305 patients with glaucoma and 55 heathy participants were included in this multicenter, cross-sectional study. The ganglion cell and inner plexiform layer (GCIPL) thickness was measured using spectral domain optical coherence tomography. Visual field measurements were performed using the Humphrey 10-2 test. All A-scan pixels (128 × 512 pixels) were allocated to the closest 10-2 location with both displacement models using degree and millimeter scales. Structure-function relationships were investigated between GCIPL thickness and corresponding visual sensitivity in nonlong (160 eyes) and long (200 eyes) axial length (AL) groups. RESULTS. In both the nonlong and long AL groups, compared with the no-displacement model, both the Drasdo and the Sjöstrand models showed that the structure-function relationship around the fovea improved (P < 0.05). The magnitude of improvement in the area was either comparable between the model or was larger for the Drasdo model than the Sjöstrand model (P < 0.05). Meanwhile, structure-function relationships outside the innermost retinal region that were based on the Drasdo and Sjöstrand models were comparable to or were even worse than (in the case of the Drasdo model) those obtained using the no-displacement model. CONCLUSIONS. Structure-function relationships evaluated based on both the Drasdo and Sjöstrand models significantly improved around the fovea, particularly when using the Drasdo model. This was not the case in other areas.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Comparing Structure-Function Relationships Based on Drasdo's and Sjöstrand's Retinal Ganglion Cell Displacement Models

Hirasawa

Fujino

Yanagisawa

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…The prevalence of myopia has markedly increased over the past three decades, especially in China [ 1 ]. In myopic eyes, there are morphological changes in the optic disc, such as β -peripapillary atrophy ( β -PPA), tilt, and rotation [ 2 ]. The myopic β -PPA, also known as the optic disc crescent, is a white area with a well-defined boundary and visible sclera due to uncovering of the retinal pigment epithelium (RPE), a common structure in myopic eyes [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Is the Retinal Vasculature Related to β-Peripapillary Atrophy in Nonpathological High Myopia? An Optical Coherence Tomography Angiography Study in Chinese Adults

Sun

Wang

You

et al. 2018

Journal of Ophthalmology

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Purpose The association between β-peripapillary atrophy and the retinal vasculature in nonpathological high myopia is unclear. The aim of this study is to investigate whether β-peripapillary atrophy contribute to the changes of the retinal vasculature using optical coherence tomography angiography. Methods In a cross-sectional study, one hundred and thirty eyes with nonpathological high myopia were included. β-peripapillary atrophy was analysed using Image J software based on fundus photographs. A 3.0 × 3.0 mm2 grid and a 4.5 × 4.5 mm2 grid were used to scan parafoveal and peripapillary regions using optical coherence tomography angiography, respectively. Vessel density and fractal dimensions of the retina and foveal avascular zone were analysed and quantified using en face projection images. Correlations between the vascular density, foveal avascular zone, and β-peripapillary atrophy were determined. Results Using multivariate analysis, β-peripapillary atrophy was negatively correlated with the vessel density in radial peripapillary capillaries (p=0.002) even after adjusting for other variables. This relationship was also confirmed in the macula (superficial retinal plexus: p < 0.05; deep retinal plexus: p < 0.05). The vessel densities in the nasal and inferior sectors were more strongly correlated with β-peripapillary atrophy. Conclusions There was a negative correlation between β-peripapillary atrophy and the retinal vasculature in highly myopic eyes, especially in radial peripapillary capillaries and deep retinal plexus. β-peripapillary atrophy can be visualized and is a convenient structural feature that can benefit the early diagnosis and detection of chorioretinal atrophy in high myopia.

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“…[16] Sung et al also reported that the greater disc tilt was associated with development of parafoveal scotoma in myopic eyes with early NTG. [17] During myopia progression, eyeball elongation resulted in scleral stretching and tilting of the optic disc. Myopic tilting of the optic disc might strain the temporal side of lamina cribrosa and axons of papillomacular bundle which make papillomacular bundle more vulnerable to glaucomatous damage.…”

Section: Discussionmentioning

confidence: 99%

“…[16] Sung et al also reported that greater disc tilt and lesser disc rotation were associated with the worse parafoveal VF defect in myopic patients with early normal tension glaucoma. [17]…”

Section: Introductionmentioning

confidence: 99%

The relationship between optic nerve head deformation and visual field defects in myopic eyes with primary open-angle glaucoma

et al. 2018

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PurposeTo investigate the relationship between the morphologic features of myopic optic nerve head (ONH) and visual field (VF) defects in myopic subjects with primary open-angle glaucoma (POAG) by intraindividual comparison.MethodsMyopic POAG subjects with unilateral glaucomatous VF defect were recruited. The morphologic features of myopic ONH, including optic disc tilt, optic disc rotation, and β-zone parapapillary atrophy (PPA) were measured from color fundus photographs. The comparisons were performed between the eyes with VF defects and the contralateral eyes without VF defects. Logistic regression analysis was performed to investigate the relationship between various ocular parameters and the presence of VF defects.ResultsWe retrospectively included 100 eyes of 50 myopic POAG subjects. (Mean age: 50.1 ± 10.0 years). The tilt ratio was similar between the paired eyes. The degree of optic disc rotation (12.96 ± 7.21°) in eyes with VF defects were statistically greater than the contralateral eyes (6.86 ± 4.30°; P < 0.001) without VF defect. The β-zone PPA-to-disc area ratio was significantly greater in eyes with VF defects than the contralateral eyes (P = 0.024) without VF defect. In multivariate logistic regression analysis, the greater degree of optic disc rotation was significantly associated with the presence of VF defects (P < 0.001). However, tilt ratio, β-zone PPA-to-disc area ratio, refractive error, and axial length were not associated with the presence of VF defects.ConclusionsAmong the morphologic features of myopic ONH, only the greater degree of the optic disc rotation was associated with the presence of VF defects in myopic subjects with POAG.

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Predicting the risk of parafoveal scotoma in myopic normal tension glaucoma: role of optic disc tilt and rotation

Cited by 15 publications

References 40 publications

Comparing Structure-Function Relationships Based on Drasdo's and Sjöstrand's Retinal Ganglion Cell Displacement Models

Comparing Structure-Function Relationships Based on Drasdo's and Sjöstrand's Retinal Ganglion Cell Displacement Models

Is the Retinal Vasculature Related to β-Peripapillary Atrophy in Nonpathological High Myopia? An Optical Coherence Tomography Angiography Study in Chinese Adults

The relationship between optic nerve head deformation and visual field defects in myopic eyes with primary open-angle glaucoma

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