“…Adequate in vivo functional islet mass in the pancreas donor is one of many factors that can have an impact on the outcome of pancreatic islet isolation. Therefore, we agree with Hubert et al [1] that a reliable method to screen functional donor islet mass in vivo has the potential to improve successful islet isolation outcomes. Other tests, such as glucose tolerance tests, beta cell secretory capacity [5], positron-emission tomography [6], and glucose-or arginineinduced acute insulin release (AIR), have been used to assess functional islet mass.…”