Predicting the need for colectomy in pediatric patients with ulcerative colitis

Clinical variables as prognostic tools in pediatric-onset ulcerative colitis: A retrospective cohort study

“…Hyams et al 25 found severity of disease at presentation-measured as >5 stools/day and daily gross blood-to be a significant risk factor for colectomy during the first 5 years of follow-up. Falcone et al 26 reported the combination of steroid dependence and pancolitis was associated with an increased need for colectomy in pediatric patients with UC. These studies are limited in their ability to guide clinical decisions.…”

Restorative Proctocolectomy for Pediatric Patients with Ulcerative Colitis

“…Falcone et al reviewed 73 patients with UC aged from 1 to 18 years and reported that those who were steroid dependent and/or who suffered from pancolitis tended to fail to seek medical treatment and thus needed a colectomy within 3 years from diagnosis. 14 Hyams et al reported that children with severe UC at the onset showed a high risk for later requiring a colectomy during the first 5 years of follow-up. 15 In our cases, 80% of the patients wee steroid dependent, and 93% had pancolitis.…”

Laparoscopic subtotal colectomy for medically refractory ulcerative colitis: the time has come

“…While some patients remain relatively asymptomatic, others present with disease manifestations requiring operative intervention [6,7]. Operative indications include failure of immunosuppressive therapy, toxic megacolon, colonic perforation, evidence of carcinoma or dysplasia, and systemic complications from immunosuppressants [8,9].…”