Predicting the Likelihood of Nonsentinel Lymph Node Metastases in Triple Negative Breast Cancer Patients With a Positive Sentinel Lymph Node: Turkish Federation of Breast Disease Associations Protocol MF09-01

Özbaş, Serdar; Özmen, Vahit; İğci, Abdullah; Müslümanoğlu, Mahmut; Özçınar, Beyza; Balkan, Müjdat; Aydoğan, Fatih; Canda, Tülay; Omer, Hammad; Aksaz, Erol; Güllüoğlu, Bahadır M.; Kayahan, Münire; Özaslan, Cihangir; Cantürk, Nuh Zafer; Mersin, Hakan; Utkan, Zafer; Koçak, Savaş; Ulufi, Nalan; Polat, Ayfer Kamalı; Andaçoğlu, Oya; Soran, Atilla

doi:10.1016/j.clbc.2011.07.004

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…For predicting non-sentinel lymph node metastasis in TNBC, some of these widely used nomograms are not much better than coin tossing, with AUCs around 0.55. It is noteworthy that such nomograms still work well in ER positive patients in the same institute (21). This phenomenon can be partly attributed to that rather than being a single subtype, triple-negative breast cancer is a general concept covering a group of diseases, with a variety in biological behavior, as well as great differences compared with other subtypes (22).…”

Section: Discussionmentioning

confidence: 99%

Nomogram for Predicting Lymph Node Involvement in Triple-Negative Breast Cancer

Cui

Zhu

2020

Front. Oncol.

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BackgroundLymph node metastasis of triple-negative breast cancer (TNBC) is essential in treatment strategy formulation. This study aimed to build a nomogram that predicts lymph node metastasis in patients with TNBC.Materials and MethodsA total of 28,966 TNBC patients diagnosed from 2010 to 2017 in the Surveillance, Epidemiology and End Results (SEER) database were enrolled, and randomized 1:1 into the training and validation sets, respectively. Univariate and multivariate logistic regression analysis were applied to identify the predictive factors, which composed the nomogram. The receiver operating characteristic curves showed the efficacy of the nomogram.ResultMultivariate logistic regression analyses revealed that age, race, tumor size, tumor primary site, and pathological grade were independent predictive factors of lymph node status. Integrating these independent predictive factors, a nomogram was successfully developed for predicting lymph node status, and further validated in the validation set. The areas under the receiver operating characteristic curves of the nomogram in the training and validation sets were 0.684 and 0.689 respectively, showing a satisfactory performance.ConclusionWe constructed a nomogram to predict the lymph node status in TNBC patients. After further validation in additional large cohorts, the nomogram developed here would do better in predicting, providing more information for staging and treatment, and enabling tailored treatment in TNBC patients.

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Section: Discussionmentioning

confidence: 99%

Nomogram for Predicting Lymph Node Involvement in Triple-Negative Breast Cancer

Cui

Zhu

2020

Front. Oncol.

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Which nomogram is best for predicting non-sentinel lymph node metastasis in breast cancer patients? A meta-analysis

Zhu

Jin

et al. 2013

Breast Cancer Res Treat

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To present a systematic [corrected] review and meta-analysis to evaluate the nomograms developed to predict non-sentinel lymph node (NSLN) metastasis in breast cancer patients. We focused on the six nomograms (Cambridge, MSKCC, Mayo, MDA, Tenon, and Stanford) that are the most widely validated. The AUCs were converted to odds ratios for the meta-analysis. In total, the Cambridge, Mayo, MDA, MSKCC, Stanford, and Tenon models were validated in 2,156, 2,431, 843, 8,143, 3,700, and 3,648 patients, respectively. The pooled AUCs for the Cambridge, MDA, MSKCC, Mayo, Tenon, and Stanford models were 0.721, 0.706, 0.715, 0.728, 0.720, and 0.688, respectively. Subgroup analysis revealed that in populations with a higher micrometastasis rate in the SLNs, the Tenon and Stanford models had a significantly higher predictive accuracy. A meta-regression analysis revealed that the SLN micrometastasis rate, but not the NSLN-positivity rate, was associated with improved predictive accuracy in the Tenon and Stanford models. The performance of the MSKCC and Cambridge models was not influenced by these two factors. All of these prediction models perform better than random chance. The Stanford model seems to be relatively inferior to the other models. The accuracy of the Tenon and Stanford models is influenced by the tumor burden in the SLNs.

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Use of Established Nomograms to Predict Non-Sentinel Lymph Node Metastasis

Matsen

Zee

2014

Curr Breast Cancer Rep

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Predicting the Likelihood of Nonsentinel Lymph Node Metastases in Triple Negative Breast Cancer Patients With a Positive Sentinel Lymph Node: Turkish Federation of Breast Disease Associations Protocol MF09-01

Cited by 4 publications

References 38 publications

Nomogram for Predicting Lymph Node Involvement in Triple-Negative Breast Cancer

Nomogram for Predicting Lymph Node Involvement in Triple-Negative Breast Cancer

Which nomogram is best for predicting non-sentinel lymph node metastasis in breast cancer patients? A meta-analysis

Use of Established Nomograms to Predict Non-Sentinel Lymph Node Metastasis

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