Predicting the intermediate syndrome in organophosphorus poisoning

Coulson, James

doi:10.4103/0972-5229.160268

Cited by 3 publications

(3 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The occurrence of this syndrome was reported in up to 18% of OP related admissions during an early case-series and recent work suggest variable occurrence from 8% to 49%. 5,[34][35][36] Present study showed occurrence of intermediate syndrome in 12.38% and its proportion was higher in severe poisoning as per the POP scale as compared to those with mild poisoning.…”

Section: Variablementioning

confidence: 82%

“…OPs inhibit the enzyme acetyl cholinesterase at variety of locations resulting in excessive accumulation of acetylcholine at muscarinic and nicotinic synapses within both peripheral and central nervous systems leading to variety of clinical effects like acute cholinergic crisis, intermediate syndrome, delayed polyneuropathy and other rare presentations. 4,5 Many patients develop respiratory failure and cardiac arrests depending upon severity of poisoning leading to deaths. 6 OP poisoning is associated with a high case fatality rate (CFR) with more preventable deaths occurring in developing countries than in developed countries and yet there are no clear-cut evidence-based guidelines for the best management of OP poisoning.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 However, there is no consensus regarding these factors to determine severity and also to predict morbidity and mortality. 5,11 Present study was conducted to study socio-demographic profile of these OP poisoning cases from rural population and to study different factors associate with morbidity and mortality in rural population that can help in identifying patients in need of intensive monitoring and treatment to prevent the deaths…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The clinico-demographic study of morbidity and mortality in patients with organophosphate compound poisoning at tertiary care hospital in rural India

Mundhe¹,

Birajdar²,

Chavan³

2017

Int J Adv Med

View full text Add to dashboard Cite

Background: Organophosphates (OP) are commonly used and potentially fatal insecticides. Given the unrestricted availability and widespread use, OP poisoning is very much common following either accidental or intentional exposures. Many parameters are proposed to predict outcome, yet there is no consensus about these parameters. This study aimed to investigate different factors associate with morbidity and mortality in rural population that can help in identifying patients in need of intensive care and treatment to prevent deaths.Methods: This was a cross-sectional observational study of 323 patients, admitted to the tertiary care rural public hospital with OP poisoning between December 2015 to November 2016.Results: Of the 323 patients studied, 62.85% were male, 227 (70.27%) were suicides, 241 (74.61%) ingested OP compounds, 40 (12.38%) patients developed intermediate syndrome and 56 (17.34%) died. There were statistically significant differences between ventilatory support group and no ventilatory group for suicidal intention, sex, comorbid psychiatric conditions, route of exposure, certain clinical features on admission, GCS score, POP scale, time from exposure to initiation of treatment, plasma pseudocholinesterase levels, oxygen saturation, and random blood sugar levels (p<0.05).Conclusions: OP poisoning is a life-threatening condition which requires immediate management. Early initiation of decontamination, atropine and pralidoxime therapy, with supportive ICU care, can save lives. Different demographic, exposure related parameters; some of the clinical features, treatment variables and certain laboratory findings can provide useful prognostic information and help to predict outcomes. A measures to control unchecked availability of these compounds and early transfer of victims to health care facility is needed to save many lives.

show abstract

Section: Variablementioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The clinico-demographic study of morbidity and mortality in patients with organophosphate compound poisoning at tertiary care hospital in rural India

Mundhe¹,

Birajdar²,

Chavan³

2017

Int J Adv Med

View full text Add to dashboard Cite

show abstract

Assessment of mechanically ventilated patients intoxicated with organophosphates by a novel surface electromyographic index

Sánchez

Mañanas

2017

Journal of Critical Care

View full text Add to dashboard Cite

The Problem of the Intermediate Syndrome Following Poisoning With Anti-Cholinesterase Agents

Tyunin

Чепур

Gogolevsky

et al. 2017

Toksikologičeskij vestnik

View full text Add to dashboard Cite

Etiology and pathogenesis current concepts of the intermediate syndrome in cases of poisoning with anticholinesterase compounds (organophosphorus compounds, carbamates) are considered in the review. Characteristics of the syndrome clinical picture and its diagnostics methods using electromyography are presented.. Data on the experience of broadly used basic antidotal agents (cholinesterase reactivators, M – and N-cholinoreceptors) and pathogenic therapy of poisonings were analyzed and summarized. To solve the problem, priority research directions were determined, such as search for formation mechanisms of the nondepolarizing neuromuscular blocker and development of methods for prophylaxis and therapy using drugs targeting N-cholinoreceptors.

show abstract

Predicting the intermediate syndrome in organophosphorus poisoning

Cited by 3 publications

References 9 publications

The clinico-demographic study of morbidity and mortality in patients with organophosphate compound poisoning at tertiary care hospital in rural India

The clinico-demographic study of morbidity and mortality in patients with organophosphate compound poisoning at tertiary care hospital in rural India

Assessment of mechanically ventilated patients intoxicated with organophosphates by a novel surface electromyographic index

The Problem of the Intermediate Syndrome Following Poisoning With Anti-Cholinesterase Agents

Contact Info

Product

Resources

About