Predicting the failure of ultrathin porous membranes in bulge tests

Gillmer, Steven R.; Fang, David Z.; Wayson, Sarah E.; Winans, Joshua D.; Abdolrahim, Niaz; DesOrmeaux, Jon Paul S.; Getpreecharsawas, Jirachai; Ellis, Jonathan D.; Fauchet, Philippe M.; McGrath, James L.

doi:10.1016/j.tsf.2017.04.004

Cited by 18 publications

(16 citation statements)

References 28 publications

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“…Other silicon‐based membranes, such as those used in the canine model, being thicker are therefore less diffusively efficient than our silicon‐nitride membranes . A major challenge when working with these membranes, however, is the brittle nature of ultrathin silicon, which can result in sudden membrane failure above a critical pressure . We have made significant improvements over the last decade in our ability to manufacture ultrathin membranes with high yield and to increase the amount of continuous membrane area.…”

Section: Introductionmentioning

confidence: 99%

Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis

Hill

Walker

Salminen

et al. 2020

Adv Healthcare Materials

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Conventional hemodialysis (HD) uses floor‐standing instruments and bulky dialysis cartridges containing ≈2 m2 of 10 micrometer thick, tortuous‐path membranes. Portable and wearable HD systems can improve outcomes for patients with end‐stage renal disease by facilitating more frequent, longer dialysis at home, providing more physiological toxin clearance. Developing devices with these benefits requires highly efficient membranes to clear clinically relevant toxins in small formats. Here, the ability of ultrathin (<100 nm) silicon‐nitride‐based membranes to reduce the membrane area required to clear toxins by orders of magnitude is shown. Advanced fabrication methods are introduced that produce nanoporous silicon nitride membranes (NPN‐O) that are two times stronger than the original nanoporous nitride materials (NPN) and feature pore sizes appropriate for middle‐weight serum toxin removal. Single‐pass benchtop studies with NPN‐O (1.4 mm2) demonstrate the extraordinary clearance potential of these membranes (105 mL min−1 m−2), and their intrinsic hemocompatibility. Results of benchtop studies with nanomembranes, and 4 h dialysis of uremic rats, indicate that NPN‐O can reduce the membrane area required for hemodialysis by two orders of magnitude, suggesting the performance and robustness needed to enable small‐format hemodialysis, a milestone in the development of small‐format hemodialysis systems.

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Section: Introductionmentioning

confidence: 99%

Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis

Hill

Walker

Salminen

et al. 2020

Adv Healthcare Materials

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“…To assess the performance of the MSN membranes, we measured the hydraulic permeance and maximum differential pressure tolerance (often referred to as burst pressure) at different slit widths (0.2, 0.5, and 1.0 µm); we also measured gas permeance as an additional characterization of these novel membrane structures. As an additional pore size comparison, nanoporous silicon nitride (NPN) membranes with cylindrical pores of average 60 nm diameter (DesOrmeaux et al, ; Gillmer et al, ) were also tested. The 0.2 µm MSN membranes, which had the highest porosity, displayed the highest nitrogen gas permeance (Figure b).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the maximum differential pressure tolerance for the 0.2 µm MSN membrane was approximately 1.8‐times higher than those for the other two MSN membranes that were twice as thick (Figure c). All else remaining constant, thinner membranes should possess proportionally lower differential pressure tolerances (Gillmer et al, ). However, increasing the porosity of a membrane increases its flexibility and so raises its differential pressure tolerance by providing a means for strain relief (Gillmer et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…All else remaining constant, thinner membranes should possess proportionally lower differential pressure tolerances (Gillmer et al, ). However, increasing the porosity of a membrane increases its flexibility and so raises its differential pressure tolerance by providing a means for strain relief (Gillmer et al, ). Our data suggests that the three‐times greater porosity of the 0.2 µm MSN membranes, compared to the 0.5 and 1.0 µm MSN membranes, may have compensated for its two‐times lower thickness and resulted in its higher maximum differential pressure tolerance.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the maximum differential pressure tolerance for the 0.2 µm MSN membrane was approximately 1.8-times higher than those for the other two MSN membranes that were twice as thick ( Figure 2c). All else remaining constant, thinner membranes should possess proportionally lower differential pressure tolerances (Gillmer et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Development of isoporous microslit silicon nitride membranes for sterile filtration applications

Wright

Miller

Csordas

et al. 2019

Biotech & Bioengineering

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The widely used 0.2/0.22 µm polymer sterile filters were developed for small molecule and protein sterile filtration but are not well-suited for the production of large nonprotein biological therapeutics, resulting in significant yield loss and production cost increases. Here, we report on the development of membranes with isoporous sub-0.2 μm rectangular prism pores using silicon micromachining to produce microslit silicon nitride (MSN) membranes. The very high porosity (~33%) and ultrathin (200 nm) nature of the 0.2 µm MSN membranes results in a dramatically different structure than the traditional 0.2/0.22 µm polymer sterile filter, which yielded comparable performance properties (including gas and hydraulic permeance, maximum differential pressure tolerance, nanoparticle sieving/fouling behavior). The results from bacteria retention tests, conducted according to the guidance of regulatory agencies, demonstrated that the 0.2 µm MSN membranes can be effectively used as sterile filters. It is anticipated that the results and technologies presented in this study will find future utility in the production of non-protein biological therapeutics and in other biological and biomedical applications. K E Y W O R D Sbiological therapeutics, silicon nanomembranes, sterile filtration

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The Modular µSiM Reconfigured: Integration of Microfluidic Capabilities to Study In Vitro Barrier Tissue Models under Flow

Mansouri

Ahmed

Ahmad

et al. 2022

Adv Healthcare Materials

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Microfluidic tissue barrier models have emerged to address the lack of physiological fluid flow in conventional "open-well" Transwell-like devices. However, microfluidic techniques have not achieved widespread usage in bioscience laboratories because they are not fully compatible with traditional experimental protocols. To advance barrier tissue research, there is a need for a platform that combines the key advantages of both conventional open-well and microfluidic systems. Here, a plug-and-play flow module is developed to introduce on-demand microfluidic flow capabilities to an open-well device that features a nanoporous membrane and live-cell imaging capabilities. The magnetic latching assembly of this design enables bi-directional reconfiguration and allows users to conduct an experiment in an open-well format with established protocols and then add or remove microfluidic capabilities as desired. This work also provides an experimentally-validated flow model to select flow conditions based on the experimental needs. As a proof-of-concept, flow-induced alignment of endothelial cells and the expression of shear-sensitive gene targets are demonstrated, and the different phases of neutrophil transmigration across a chemically stimulated endothelial monolayer under flow conditions are visualized. With these experimental capabilities, it is anticipated that both engineering and bioscience laboratories will adopt this reconfigurable design due to the compatibility with standard open-well protocols.

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Predicting the failure of ultrathin porous membranes in bulge tests

Cited by 18 publications

References 28 publications

Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis

Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis

Development of isoporous microslit silicon nitride membranes for sterile filtration applications

The Modular µSiM Reconfigured: Integration of Microfluidic Capabilities to Study In Vitro Barrier Tissue Models under Flow

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