“…Maintaining the skin of the foot in an optimally-hydrated condition helps to prevent the development of fissuring and ulcer formation [ 6 , 7 , 8 ]. Studies [ 9 , 10 , 11 , 12 ] show the combined effects of increasing or decreasing temperature and relative humidity on the behavior of human skin, show an influence of skin hydration and wetness, and some previous studied collected and analyzed the skin changes and the development of superficial ulcer and support surface, considering the microclimate [ 13 , 14 ]. The thermoregulatory sweating abnormality signified early damage in diabetic feet, and assessing skin conditions should help identify neuropathy in diabetic patients with at-risk feet conditions [ 1 ].…”