Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study

Tran, Maxwell; Lefebvre, Diana L.; Dharma, Christoffer; Dai, David; Mandhane, Piush J.; Subbarao, Padmaja; Turvey, Stuart E.; Anand, S. S.; Azad, Meghan B.; Becker, Allan B.; Befus, A. Dean; Bräuer, Michael; Brook, J. R.; Chen, E.; Cyr, Michael; Daley, Denise; Dell, Sharon D.; Denburg, J. A.; Duan, Qingling; Eiwegger, Thomas; Grasemann, Hartmut; HayGlass, Kent T.; Hegele, Richard G.; Holness, D. L.; Hystad, Perry; Kobor, Michæl S.; Kollmann, Tobias R.; Kozyrskyj, AL; Laprise, Catherine; Lou, Wendy; Macri, Joseph; Miller, Greg; Moraes, TJ; Paré, Peter D.; Ramsey, Clare D.; Ratjen, Félix; Sandford, Andrew J.; Scott, J. Anthony G.; Sears, Malcolm R.; Silverman, Frances; Simons, Elinor; Takaro, Tim K.; Tebbutt, Scott J.; To, Teresa

doi:10.1016/j.jaci.2017.08.024

Cited by 150 publications

(148 citation statements)

References 37 publications

Supporting

Mentioning

120

Contrasting

Unclassified

Order By: Relevance

“…However, we and others have noted that "atopic dermatitis" is often a misnomer as quite frequently AD is diagnosed in the absence of allergic sensitization. In another publication from this population-based, longitudinal birth cohort, we reported that AD without evidence of allergic sensitization was not associated with an increased risk of subsequent asthma, 35 whereas the combination of AD and allergic sensitization at age 1 year was associated with increased risks for both asthma and food allergy at 3 years. The combined effect of diagnosed AD and allergic sensitization was greater than the sum of their individual effects on these risks.…”

Section: Discussionmentioning

confidence: 76%

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases

Dharma

Lefebvre

Tran

et al. 2017

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 76%

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases

Dharma

Lefebvre

Tran

et al. 2017

Clin Experimental Allergy

Self Cite

View full text Add to dashboard Cite

show abstract

“…We have previously reported that the clinical assessment of AD using the UK Working party criteria provided the strongest correlation with clinical outcomes of allergic diseases at 3 years. 14 We have now extended follow-up time, and evaluated which AD diagnostic measure was most associated with clinical outcomes (atopy, asthma, allergic rhinitis, and food allergy) at age 5 years. We applied unadjusted Poisson regression models to calculate the risk ratios of exhibiting these characteristics associated with AD diagnosed by each method.…”

Section: Discussionmentioning

confidence: 99%

“…1 Other studies have utilised electronic medical records 7,8 seeking a diagnosis by an attending physician, while others relied on parentreported physician diagnosis, where parents were typically asked "Has your child been diagnosed with eczema?". [9][10][11][12] Some studies have employed direct examination of the child by a health care professional, [13][14][15][16] while others have combined more than one of these methods. 13,15 It is unknown if these methods are comparable.…”

Section: Introductionmentioning

confidence: 99%

Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria‐based assessment

Dharma

Lefebvre

Tran

et al. 2018

Paediatric Perinatal Epid

Self Cite

View full text Add to dashboard Cite

Background Persisting atopic dermatitis (AD) is known to be associated with more serious allergic diseases at later ages; however, making an accurate diagnosis during infancy is challenging. We assessed the diagnostic performance of questionnaire‐based AD measures with criteria‐based in‐person clinical assessments at age 1 year and evaluated the ability of these diagnostic methods to predict asthma, allergic rhinitis and food allergies at age 5 years. Methods Data relate to 3014 children participating in the Canadian Healthy Infant Longitudinal Development (CHILD) Study who were directly observed in a clinical assessment by an experienced healthcare professional using the UK Working Party criteria. The majority (2221; 73.7%) of these children also provided multiple other methods of AD ascertainment: a parent reporting a characteristic rash on a questionnaire, a parent reporting the diagnosis provided by an external physician and a combination of these two reports. Results Relative to the direct clinical assessment, the area under the Receiver Operating Characteristic curve for a parental report of a characteristic rash, reported physician diagnosis and a combination of both were, respectively, 0.60, 0.69 and 0.70. The strongest predictor of asthma at 5 years was AD determined by criteria‐based in‐person clinical assessment followed by the combination of parental and physician report. Conclusions These findings suggest that questionnaire data cannot accurately substitute for assessment by experienced healthcare professionals using validated criteria for diagnosis of atopic dermatitis. Combining the parental report with diagnosis by a family physician might sometimes be appropriate (eg to avoid costs of a clinical assessment).

show abstract

“…In many children with asthma, the appearance of different allergic conditions follows a sequence that has been labelled the “atopic march” [76]. This sequence connects the different expressions of allergic diseases that vary with age, which often have transient symptoms.…”

Section: Reviewmentioning

confidence: 99%

Aeroallergens in Canada: Distribution, Public Health Impacts, and Opportunities for Prevention

Sierra-Heredia

North

Brook

et al. 2018

IJERPH

View full text Add to dashboard Cite

Aeroallergens occur naturally in the environment and are widely dispersed across Canada, yet their public health implications are not well-understood. This review intends to provide a scientific and public health-oriented perspective on aeroallergens in Canada: their distribution, health impacts, and new developments including the effects of climate change and the potential role of aeroallergens in the development of allergies and asthma. The review also describes anthropogenic effects on plant distribution and diversity, and how aeroallergens interact with other environmental elements, such as air pollution and weather events. Increased understanding of the relationships between aeroallergens and health will enhance our ability to provide accurate information, improve preventive measures and provide timely treatments for affected populations.

show abstract

Predicting the atopic march: Results from the Canadian Healthy Infant Longitudinal Development Study

Abstract: Atopic dermatitis without concomitant allergic sensitization was not associated with an increased risk of asthma. In combination, atopic dermatitis and allergic sensitization had strong interactive effects on both asthma and food allergy risk at age 3 years.

Cited by 150 publications

References 37 publications

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases

Patterns of allergic sensitization and atopic dermatitis from 1 to 3 years: Effects on allergic diseases

Diagnosing atopic dermatitis in infancy: Questionnaire reports vs criteria‐based assessment

Aeroallergens in Canada: Distribution, Public Health Impacts, and Opportunities for Prevention

Contact Info

Product

Resources

About