Predicting tDCS treatment outcomes of patients with major depressive disorder using automated EEG classification

Al-Kaysi, Alaa M.; Al-Ani, Ahmed; Loo, Colleen; Powell, Tamara Y.; Martin, Donel; Breakspear, Michael; Boonstra, Tjeerd W.

doi:10.1016/j.jad.2016.10.021

Cited by 77 publications

(61 citation statements)

References 43 publications

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“…Consistent with this hypothesis, stimulation to the IPS, which shows strong prefrontal connections, lead to impairments on a stop signal task compared to stimulation of the tempoparietal junction, an area not connected to the prefrontal cortex 74 . Also consistent with this network hypothesis of TMS effects, recent work has shown that prefrontal stimulation alters parietal activity 75 , and that the therapeutic effects of prefrontal stimulation may be mediated in part through these changes in parietal activity 76 .…”

Section: Discussionmentioning

confidence: 61%

Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety

et al. 2020

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Anxiety disorders are the most prevalent mental disorders, with few effective neuropharmacological treatments, making treatments development critical. While noninvasive neuromodulation can successfully treat depression, few treatment targets have been identified specifically for anxiety disorders. Previously, we showed that shock threat increases excitability and connectivity of the intraparietal sulcus (IPS). Here we tested the hypothesis that inhibitory repetitive transcranial magnetic stimulation (rTMS) targeting this region would reduce induced anxiety. Subjects were exposed to neutral, predictable, and unpredictable shock threat, while receiving double-blinded, 1 Hz active or sham IPS rTMS. We used global brain connectivity and electric-field modelling to define the single-subject targets. We assessed subjective anxiety with online ratings and physiological arousal with the startle reflex. Startle stimuli (103 dB white noise) probed fear and anxiety during the predictable (fear-potentiated startle, FPS) and unpredictable (anxietypotentiated startle, APS) conditions. Active rTMS reduced both FPS and APS relative to both the sham and no stimulation conditions. However, the online anxiety ratings showed no difference between the stimulation conditions. These results were not dependent on the laterality of the stimulation, or the subjects' perception of the stimulation (i.e. active vs. sham). Results suggest that reducing IPS excitability during shock threat is sufficient to reduce physiological arousal related to both fear and anxiety, and are consistent with our previous research showing hyperexcitability in this region during threat. By extension, these results suggest that 1 Hz parietal stimulation may be an effective treatment for clinical anxiety, warranting future work in anxiety patients.

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Section: Discussionmentioning

confidence: 61%

Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety

et al. 2020

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“…A number of studies have confirmed the role of tDCS in antidepressant treatment (Vigod et al, 2014 ; Al-Kaysi et al, 2017 ; Brennan et al, 2017 ). At present, the left and right DLPFC are typically used as anode and cathode stimulation sites for the majority of tDCS treatment methods, which can increase the excitability of the left DLPFC and inhibit the excitability of the right DLPFC to alleviate depressive symptoms (Meron et al, 2015 ).…”

Section: Transcranial Direct Current Stimulation (Tdcs)mentioning

confidence: 93%

Recent Advances in Non-invasive Brain Stimulation for Major Depressive Disorder

Shui

Sheng

et al. 2017

Front. Hum. Neurosci.

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Non-invasive brain stimulation (NBS) is a promising treatment for major depressive disorder (MDD), which is an affective processing disorder involving abnormal emotional processing. Many studies have shown that repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) over the prefrontal cortex can play a regulatory role in affective processing. Although the clinical efficacy of NBS in MDD has been demonstrated clinically, the precise mechanism of action remains unclear. Therefore, this review article summarizes the current status of NBS methods, including rTMS and tDCS, in the treatment of MDD. The article explores possible correlations between depressive symptoms and affective processing, highlighting the relevant affective processing mechanisms. Our review provides a reference for the safety and efficacy of NBS methods in the clinical treatment of MDD.

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“…These observed effects on EEG components, which are considered to have a source in medial frontal cortex, suggest tDCS to affect cortical functioning beyond focal changes at the stimulation site. Two studies by Al-Kaysi et al utilized machine learning methods in EEG data of 10 MDD patients to predict clinical outcomes following tDCS applications over the left DLPFC [ 30 , 31 ]. The authors demonstrated that a multichannel deep belief network can be used to accurately classify between the EEG data that was recorded after active and sham tDCS [ 30 ] and identified features from the baseline resting-state EEG that differentiate patients who respond to tDCS treatment from those who do not [ 31 ].…”

Section: Resultsmentioning

confidence: 99%

“…Two studies by Al-Kaysi et al utilized machine learning methods in EEG data of 10 MDD patients to predict clinical outcomes following tDCS applications over the left DLPFC [ 30 , 31 ]. The authors demonstrated that a multichannel deep belief network can be used to accurately classify between the EEG data that was recorded after active and sham tDCS [ 30 ] and identified features from the baseline resting-state EEG that differentiate patients who respond to tDCS treatment from those who do not [ 31 ]. Al-Kaysi et al [ 30 , 31 ] also found frontal channels to perform better in predicting clinical scores, while the parietal-occipital channels better in cognition score.…”

Section: Resultsmentioning

confidence: 99%

Modulation of Electrophysiology by Transcranial Direct Current Stimulation in Psychiatric Disorders: A Systematic Review

Kim

Kwak

Lee

et al. 2018

Psychiatry Investig

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Objective Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique increasingly used to relieve symptoms of psychiatric disorders. Electrophysiologic markers, such as electroencephalography (EEG) and event-related potentials (ERP), have high temporal resolution sensitive to detect plastic changes of the brain associated with symptomatic improvement following tDCS application. Methods We performed systematic review to identify electrophysiological markers that reflect tDCS effects on plastic brain changes in psychiatric disorders. A total of 638 studies were identified by searching PubMed, Embase, psychINFPO. Of these, 21 full-text articles were assessed eligible and included in the review. Results Although the reviewed studies were heterogeneous in their choices of tDCS protocols, targeted electrophysiological markers, and disease entities, their results strongly support EEG/ERPs to sensitively reflect plastic brain changes and the associated symptomatic improvement following tDCS. Conclusion EEG/ERPs may serve a potent tool in revealing the mechanisms underlying psychiatric symptoms, as well as in localizing the brain area targeted for stimulation. Future studies in each disease entities employing consistent tDCS protocols and electrophysiological markers would be necessary in order to substantiate and further elaborate the findings of studies included in the present systematic review.

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Predicting tDCS treatment outcomes of patients with major depressive disorder using automated EEG classification

Cited by 77 publications

References 43 publications

Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety

Low-frequency parietal repetitive transcranial magnetic stimulation reduces fear and anxiety

Recent Advances in Non-invasive Brain Stimulation for Major Depressive Disorder

Modulation of Electrophysiology by Transcranial Direct Current Stimulation in Psychiatric Disorders: A Systematic Review

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