Predicting tablet tensile strength with a model derived from the gravitation-based high-velocity compaction analysis data

Tanner, Timo; Antikainen, Osmo; Pollet, Arne; Räikkönen, Heikki; Ehlers, Henrik; Juppo, Anne; Yliruusi, Jouko

doi:10.1016/j.ijpharm.2019.05.024

Cited by 10 publications

(1 citation statement)

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“…The force chain network is unique and historic due to friction [19]. After tablet formation, the force chains between particles at this time include, but are not limited to, hydrogen bonding, van der Waals bonding, and solid bridge formation [20]. DEM can capture these micromechanical behavioral features from the particle scale.…”

Section: Introductionmentioning

confidence: 99%

Evolution characteristics of micromechanics provides insights into the microstructure of pharmaceutical tablets fabricated by bimodal mixtures

Zhao

Luo

et al. 2023

Preprint

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This research focuses on the evolution of mechanical behavior of bimodal mixtures undergoing compaction and diametrical compression. The clusters were built and discrete element modeling (DEM) was used to investigate the densification process and micromechanics of bimodal mixtures. Additionally, a more comprehensive investigate of the respective breakage of the bimodal mixtures has been carried out. On this basis, qualitative and quantitative analysis of the stress, force chain, contact bonds and density field evolution characteristics of the clusters are investigated during the compression process. The entire loading process of the clusters is divided into three stages: rearrangement, breakage and elastic-plastic deformation. Additionally, there are differences in the evolution of micromechanics behavior of different particles in the bimodal mixture, with PGS breakage and deformation occurring before MCC. With the tablet deformation, the fragmentation process of the tablet started at the point of contact and extended toward the center, and the curvature of the force chain increased. This approach may potentially hold a valuable new information relevant to important transformation forms batch manufacturing to advanced manufacturing for the oral solid dosage form.

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Section: Introductionmentioning

confidence: 99%