Predicting Success: Patterns of Cortical Activation and Deactivation Prior to Response Inhibition

Hester, Robert; Murphy, Kevin; Foxe, John J.; Foxe, Deirdre M.; Javitt, Daniel C.; Garavan, Hugh

doi:10.1162/089892904970726

Cited by 126 publications

(109 citation statements)

References 47 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings are consistent with other evidence that TID in task-extraneous regions facilitates optimal performance, and that its absence is associated with performance decrements (26,47). These findings extend this work in two important ways.…”

Section: Discussionsupporting

confidence: 92%

“…A baseline comparison is necessary to resolve whether differential activity between two conditions, such as error vs. correct trials, is due to a relative increase in activation during errors, a relative decrease in activation during correct trials, or both (24). Two studies that compared error and correct trials with fixation did not report differential TID between the two conditions (2,47). Differences in various factors that influence TID, including stimulus presentation rate and task difficulty (48), may account for discrepant findings.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission

Polli

Barton

Cain

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

178

163

View full text Add to dashboard Cite

The anterior cingulate cortex (ACC) participates in both performance optimization and evaluation, with dissociable contributions from dorsal (dACC) and rostral (rACC) regions. Deactivation in rACC and other default-mode regions is important for performance optimization, whereas increased rACC and dACC activation contributes to performance evaluation. Errors activate both rACC and dACC. We propose that this activation reflects differential errorrelated involvement of rACC and dACC during both performance optimization and evaluation, and that these two processes can be distinguished by the timing of their occurrence within a trial. We compared correct and error antisaccade trials. We expected errors to correlate with an early failure of rACC deactivation and increased activation of both rACC and dACC later in the trial. Eighteen healthy subjects performed a series of prosaccade and antisaccade trials during event-related functional MRI. We estimated the hemodynamic responses for error and correct antisaccades using a finite impulse-response model. We examined ACC activity by comparing error and correct antisaccades with a fixation baseline and error to correct antisaccades directly. Compared with correct antisaccades, errors were characterized by an early bilateral failure of deactivation of rACC and other default-mode regions. This difference was significant in rACC. Errors also were associated with increased activity in both rACC and dACC later in the trial. These results show that accurate performance involves deactivation of the rACC and other default mode regions and suggest that both rACC and dACC contribute to the evaluation of error responses.default-mode network ͉ performance evaluation ͉ task-induced deactivation ͉ inhibition ͉ cognition E lectrophysiological and neuroimaging studies consistently report anterior cingulate cortex (ACC) activity during error commission (1-5). The ACC, however, is a heterogeneous structure that can be parsed into dorsal (dACC) and rostral (rACC) regions based on cytoarchitecture, function, and connectivity (6-9). The dACC extends caudally from the genu of the corpus callosum to the vertical plane of the anterior commissure and connects with the lateral prefrontal cortex and hippocampus to regulate effortful cognitive operations. The rACC lies anterior and ventral to the genu of the corpus callosum and forms a circuit with the amygdala, insula, and ventral striatum to oversee emotional processing (for review, see ref. 10). Given these specializations, it is likely that the dACC and rACC make different contributions during error commission. In the present study, we examined activity in both these regions during different phases of error commission.Error-related activity in both rACC and dACC is thought to reflect their contributions to performance evaluation (2, 5, 11). The dACC is believed to be the primary generator of the error-related negativity (ERN) (5, 12), an event-related potential occurring 80-180 ms post-error (13), although a generator in the medial prefrontal cor...

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission

Polli

Barton

Cain

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

178

163

View full text Add to dashboard Cite

show abstract

“…Thus, our findings are principally in concordance with earlier data supporting the idea that the dPMC is strongly involved in visuomotor association learning (Toni et al 1999;Toni et al 2001). The right (ipsilateral) hemispheric activation in the dorsal PMC is consistent with results of the group of Garavan et al (1999;Hester et al 2004) in showing that this area might be strongly involved in the inhibitory control of actions. Inhibition of movements is a necessary consequence of visuomotor learning because incorrect visuomotor association have to be prevented.…”

Section: Preparation For Motor Responsesupporting

confidence: 93%

Neuronal Modifications During Visuomotor Association Learning Assessed by Electric Brain Tomography

et al. 2006

View full text Add to dashboard Cite

Summary: In everyday life specific situations need specific reactions. Through repetitive practice, such stimulus-response associations can be learned and performed automatically. The aim of the present EEG study was the illustration of learning dependent modifications in neuronal pathways during short-term practice of visuomotor associations. Participants performed a visuomotor association task including four visual stimuli, which should be associated with four keys, learned by trial and error. We assumed that distinct cognitive processes might be dominant during early learning e.g., visual perception and decision making. Advanced learning, however, might be indicated by increased neuronal activation in integration-and memory-related regions. For assessment of learning progress, visual-and movement-related brain potentials were measured and compared between three learning stages (early, intermediate, and late). The results have revealed significant differences between the learning stages during distinct time intervals. Related to visual stimulus presentation, Low Resolution Electromagnetic Brain Tomography (LORETA) revealed strong neuronal activation in a parieto-prefrontal network in time intervals between 100-400 ms post event and during early learning. In relation to the motor response neuronal activation was significantly increased during intermediate compared to early learning. Prior to the motor response (120-360 ms pre event), neuronal activation was detected in the cingulate motor area and the right dorsal premotor cortex. Subsequent to the motor response (68-430 ms post event) there was an increase in neuronal activation in visuomotor-and memory-related areas including parietal cortex, SMA, premotor, dorsolateral prefrontal, and parahippocampal cortex. The present study has shown specific time elements of a visuomotor-memory-related network, which might support learning progress during visuomotor association learning.

show abstract

“…One important caveat regarding the left prefrontal dominance in set shifting revealed by our previous studies is that our modified WCST allowed subjects to respond slowly (Ϸ1,000 ms; see Fig. 2), unlike task switching paradigms in other studies where responses are made more rapidly, thus requiring inhibition of inappropriate responses implemented in the right prefrontal cortex (32)(33)(34)(35)(36). This task difference may account for the right frontal cortical involvement in task switching revealed by previous neuroimaging and neuropsychological studies (37,38).…”

Section: Discussionmentioning

confidence: 88%

Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference

Konishi

Chikazoe

Jimura

et al. 2005

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Once one cognitive set dominates our behavior, it continues to influence subsequent behavior for a while even after a task to be performed is changed to another. Despite abundant knowledge of the inhibitory mechanisms that are recruited at the first trial after the change (the first inhibition trial), little is known about the inhibition of prolonged proactive interference from a previous set that lingers for several trials after the first inhibition trial. The present functional MRI study explored the neural mechanisms for inhibition of a previous set that were recruited after the first inhibition trial. A modified Wisconsin Card Sorting Test was used where ''dual-match stimuli'' were intermittently presented and allowed subjects to perform correctly based on previously appropriate, now inappropriate, responses. In response to the dualmatch stimulus at ''release'' trials presented after the first inhibition trials, the subjects were transiently exempted from inhibiting the prolonged previous set. As expected from the exempted inhibitory demands, significant reaction time decrease was revealed in the release trials. Consistent with the behavioral results, transient signal decrease time-locked to the release trials was revealed in the left anterior part of the superior frontal sulcus. Moreover, the anterior prefrontal region was not sensitive to the task change, which exhibited a marked contrast to the left posterior inferior prefrontal region that showed significant signal changes in both events. These results revealed multiple inhibitory mechanisms in the lateral prefrontal cortex that are recruited in different temporal contexts of the interference from a previous cognitive set.

show abstract

Predicting Success: Patterns of Cortical Activation and Deactivation Prior to Response Inhibition

Cited by 126 publications

References 47 publications

Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission

Rostral and dorsal anterior cingulate cortex make dissociable contributions during antisaccade error commission

Neuronal Modifications During Visuomotor Association Learning Assessed by Electric Brain Tomography

Neural mechanism in anterior prefrontal cortex for inhibition of prolonged set interference

Contact Info

Product

Resources

About