Predicting submaximal oxygen consumption during treadmill running in mice

Fernando, Pasan; Bonen, Arend; Hoffman‐Goetz, Laurie

doi:10.1139/y93-128

Cited by 133 publications

(91 citation statements)

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“…Mice that received higher subjective scores for trial quality were those that were able to run without much external stimulation (i.e., without much electrical stimulation or manual prodding). Fernando et al (13) noted that volitional running was easily maintained in mice without the use of electrical stimulation at speeds below 1.2 km/h (see also Ref. 6).…”

Section: Discussionmentioning

confidence: 99%

Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus)

Swallow

Garland

Carter

et al. 1998

Journal of Applied Physiology

192

200

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. Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus). J. Appl. Physiol. 84(1): 69-76, 1998.-An animal model was developed to study effects on components of exercise physiology of both ''nature'' (10 generations of genetic selection for high voluntary activity on running wheels) and ''nurture'' (7-8 wk of access or no access to running wheels, beginning at weaning). At the end of the experiment, mice from both wheel-access groups were significantly lighter in body mass than mice from sedentary groups. Within the wheel-access group, a statistically significant, negative relationship existed between activity and final body mass. In measurements of maximum oxygen consumption during forced treadmill exercise (V O 2 max ), mice with wheel access were significantly more cooperative than sedentary mice; however, trial quality was not a significant predictor of individual variation in V O 2 max . Nested two-way analysis of covariance demonstrated that both genetic selection history and access to wheels had significant positive effects on V O 2 max . A 12% difference in V O 2 max existed between wheelaccess selected mice, which had the highest mass-corrected V O 2 max , and sedentary control mice, which had the lowest. The respiratory exchange ratio at V O 2 max was also significantly lower in the wheel-access group. Our results suggest the existence of a possible genetic correlation between voluntary activity levels (behavior) and aerobic capacity (physiology).

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Section: Discussionmentioning

confidence: 99%

Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus)

Swallow

Garland

Carter

et al. 1998

Journal of Applied Physiology

192

200

View full text Add to dashboard Cite

show abstract

“…Exercise training began at 10 m/min, 0% grade, for 10 minutes for 5 d/wk on weeks 1 and 2, and was systematically increased until the desired exercise protocol was achieved. This training intensity corresponds to f70% to 75% of murine maximal oxygen uptake (14). Electrical stimulation was not used to encourage the animals to run.…”

Section: Methodsmentioning

confidence: 99%

Effects of Exercise Training on Antitumor Efficacy of Doxorubicin in MDA-MB-231 Breast Cancer Xenografts

Jones

Eves

Courneya

et al. 2005

Clinical Cancer Research

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Purpose: Exercise is becoming readily accepted as a beneficial adjunct therapy to maintain or enhance quality of life in breast cancer patients undergoing adjuvant chemotherapy. An essential precursor to these studies is to investigate whether exercise modulates the antitumor efficacy of chemotherapeutic agents. Experimental Design: Athymic female mice were transplanted with MDA-MB-231 breast xenografts and randomly assigned to one of four groups (n = 21 per group): (a) control, (b) exercise-only, (c) doxorubicin-only, or (d) exercise + doxorubicin. Exercise groups performed progressive treadmill running up to 18 m/min at 0% grade for 45 minutes, 5 d/wk for 8 weeks.Results: Tumor growth delay was significantly longer in the doxorubicin-only and exercise + doxorubicin groups compared with the control (median 42 versus 25 days, P = 0.0082; 36 versus 25 days, P = 0.029, respectively) and exercise-only groups (median 42 versus 25 days, P = 0.029; 36 versus 25 days, P = 0.080, respectively). There was no significant difference between the doxorubicin-only and exercise + doxorubicin groups (median 42 versus 36 days, P = 0.33), suggesting that moderate intensity exercise does not significantly influence doxorubicininduced tumor growth delay. Conclusion:These studies are essential to fully understand the safety and application of exercise as a supportive intervention in cancer control.

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“…Animals then either remained sedentary or began running on a treadmill (0.7 mph, 0% grade). This work rate results in a rate of oxygen consumption that is ϳ85% of maximum in the mouse (8). After 30 min, animals were anesthetized with pentobarbital sodium.…”

Section: Methodsmentioning

confidence: 99%

Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo

Halseth

Bracy

Wasserman

1999

American Journal of Physiology-Endocrinology and Metabolism

101

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. Overexpression of hexokinase II increases insulin-and exercise-stimulated muscle glucose uptake in vivo. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E70-E77, 1999.-The hypothesis of this investigation was that glucose uptake would be increased in skeletal muscle of transgenic mice (TG) overexpressing hexokinase II (HK II) compared with their nontransgenic littermates (NTG) during euglycemic hyperinsulinemia and treadmill exercise. For insulin experiments, catheters were surgically implanted in the jugular vein and carotid artery for infusions and sampling, respectively. Conscious mice underwent experiments ϳ5 days later in which 4 mU·kg Ϫ1 · min Ϫ1 insulin and variable glucose (n ϭ 7 TG and n ϭ 7 NTG) or saline (n ϭ 5 TG and n ϭ 4 NTG) was infused for 140 min. Over the last 40 min of the experiments, 2-deoxy-[ 3 H]glucose ([2-3 H]DG) was infused, after which muscles were removed. For the exercise experiments, jugular vein catheters were surgically implanted. Five days later, mice received a bolus of [2-3 H]DG and then remained sedentary (n ϭ 6 TG and n ϭ 8 NTG) or ran on a motorized treadmill (n ϭ 12 TG and n ϭ 8 NTG) for 30 min. TG and NTG had similar muscle [2-3 H]DG 6-phosphate ([2-3 H]DGP) accumulation in the basal state (P Ͼ 0.05). In the hyperinsulinemic experiments, TG required ϳ25% more glucose to maintain euglycemia (P Ͻ 0.05), and muscle [2-3 H]DGP accumulation normalized to infusate [2-3 H]DG was similarly increased (P Ͻ 0.05). In the exercise experiments, muscle [2-3 H]DGP accumulation was significantly greater in TG than NTG (P Ͻ 0.05). In conclusion, we did not detect an effect of HK II overexpression on muscle [2-3 H]DGP accumulation under basal conditions. Hyperinsulinemia and exercise shift the control of muscle glucose uptake so that phosphorylation is a more important determinant of the rate of this process. transgenic mice; glucose phosphorylation; 2-deoxyglucose

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Predicting submaximal oxygen consumption during treadmill running in mice

Cited by 133 publications

References 0 publications

Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus)

Effects of voluntary activity and genetic selection on aerobic capacity in house mice (Mus domesticus)

Effects of Exercise Training on Antitumor Efficacy of Doxorubicin in MDA-MB-231 Breast Cancer Xenografts

Overexpression of hexokinase II increases insulinand exercise-stimulated muscle glucose uptake in vivo

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