Predicting serious bacterial infection in febrile young infants utilizing body temperature

Nomura, Osamu; Ihara, Takateru; Sakakibara, Hiroshi; Hirokoshi, Yuho; Inoue, Nobuaki

doi:10.1111/ped.13831

Cited by 9 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While fever may be caused by simple viral infections, it can also arise from serious bacterial infections (SBI), which can be life threatening. Specifically, for infants younger than 3 months with fever, the risk of SBI such as meningitis, urinary tract infection, and bacteremia higher compared to older children 1‐4 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the accuracy of immature granulocyte percentage in predicting pediatric serious bacterial infection

Güngör

Göktüğ

Tekeli

et al. 2021

Int J Lab Hematology

View full text Add to dashboard Cite

Introduction Serious bacterial infections (SBI) are major causes of mortality and morbidity in children. The aim of this study was to determine the accuracy of the immature granulocyte (IG) percentage in predicting SBI. Methods Patients admitted to the pediatric emergency department with fever were divided into two groups: with SBI and with non‐SBI. White blood cell (WBC) count, absolute neutrophil count (ANC), C‐reactive protein (CRP), and the percentage of IG value were recorded, and their accuracy in predicting SBI was evaluated. Results Sixty‐one (14.3%) patients fell into the SBI group and 367 (85.7%) were with non‐SBI. Mean IG percentage among SBI patients was 0.84 ± 1.21 and 0.27 ± 0.20 for with non‐SBI patients (P = .001). Based on disease, the highest IG percentage was found in patients diagnosed with sepsis (IG 3.7 ± 3.5%) and with bacterial meningitis (IG 1.6 ± 1.3%). The area under the curve (AUC) of IG percentage to predict SBI was 0.83 with 95% confidence interval (CI) [0.78‐0.88]; WBC was 0.76 (95% CI 0.70‐0.83); ANC was 0.73 (95% CI 0.67‐0.80), and CRP was 0.79 (95% CI 0.73‐0.85). When infection markers were compared to the most appropriate cut‐off values in predicting SBI, IG percentage showed the highest sensitivity and specificity. When the cut‐off value was determined as >0.35 for IG percentage, sensitivity was 75.4% and specificity was 76.6% in predicting SBI. Conclusion Patients with SBI had a higher IG percentage. Compared to other biomarkers, IG percentage had higher sensitivity and specificity in predicting SBI.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of the accuracy of immature granulocyte percentage in predicting pediatric serious bacterial infection

Güngör

Göktüğ

Tekeli

et al. 2021

Int J Lab Hematology

View full text Add to dashboard Cite

show abstract

“…Tokyo Metropolitan Children’s Medical Center is a pediatric tertiary care center in Tokyo, Japan with about 38 000 annual pediatric visits to the ED. While the initial management of patients is usually provided by pediatric or emergency medicine residents, board‐certified emergency physicians or pediatricians supervise patient care. The attending physicians determine the indications for treatment according to patient care guidelines.…”

Section: Methodsmentioning

confidence: 99%

Metered‐dose inhaler ipratropium bromide for children with acute asthma exacerbation: A prospective, non‐randomized, observational study

Nomura

Ihara

Morikawa

et al. 2020

Pediatrics International

Self Cite

View full text Add to dashboard Cite

Background Ipratropium bromide (IB), when administered with β2‐agonists, is effective in reducing hospital admissions of children presenting to the emergency department (ED) with severe asthma. While IB is commonly delivered in its nebulized form, using a metered‐dose inhaler (MDI), can, reportedly, shorten patients’ length of stay in the ED. However, the effectiveness and safety of IB administration using an MDI with a spacer have not been established. This study aimed to investigate the effectiveness and safety of MDI‐delivered IB in pediatric patients with acute asthma exacerbation. Methods This prospective, non‐randomized, observational study included patients aged ≥4 years with a history of severe asthma exacerbation. Patients received IB via MDI with a spacer three times at 20‐min intervals. IB use was determined by the physicians’ treatment policy. Propensity score matching was used to adjust the confounding factors related to IB administration. Results Of the 158 patients, 88 were treated with IB and 70 were treated without IB. A propensity score‐matching analysis extracted 54 patients from each group. We found no statistical difference in the admission rate of the two groups (IB group: 25.9% vs non‐IB group: 31.5%; P = 0.67). The post‐treatment modified pulmonary index scores (mean ± SD) were also similar (IB: 6.6 ± 2.0 vs non‐IB: 6.3 ± 2.5; P = 0.53). Only one patient (1.0%) treated with IB experienced vomiting, which resolved spontaneously. Conclusion The metered‐dose inhaler IB was ineffective in reducing the admission rate possibly because it was less effective than a nebulizer for IB inhalation.

show abstract

“…There were approximately 38,000 annual pediatric visits to the ED of the hospital. While the initial patient management is usually provided by pediatric or emergency medicine residents and pediatric emergency medicine fellows, board-certificated emergency medicine physicians or pediatricians supervise patient care [ 15 , 16 ]. Patients with sepsis or suspected sepsis were treated based on the institutional protocol by following the International Pediatric Sepsis Consensus Conference (2005) [ 17 ] and Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock (2012) [ 18 ].…”

Section: Methodsmentioning

confidence: 99%

Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock

et al. 2021

Self Cite

View full text Add to dashboard Cite

(1) Background: It is critical to administer antibiotics and fluid bolus within 1 h of recognizing sepsis in pediatric patients. This study aimed to identify the predictor of the successful completion of a 1-h sepsis bundle for infants with suspected sepsis. (2) Methods: This is an observational study using a prospective registry including febrile young infants (aged < 90 days) who visited a pediatric emergency department with a core body temperature of 38.0 °C or higher and 36.0 °C or lower. Univariate and logistic regression analyses were conducted to determine the predictor (s) of successful sepsis bundle completion. (3) Results: Of the 323 registered patients, 118 patients with suspected sepsis were analyzed, and 38 patients (32.2%) received a bundle-compliant treatment. Among potential variables, such as age, sex, and vital sign parameters, the logistic regression analysis showed that heart rate (odds ratio: OR 1.02; 95% confidence interval: 1.00–1.04) is a significant predictor of the completion of a 1-h sepsis bundle. (4) Conclusions: We found that tachycardia facilitated the sepsis recognition and promoted the successful completion of a 1-h sepsis bundle for young infants with suspected septic shock and a possible indicator for improving the quality of the team-based sepsis management.

show abstract

Predicting serious bacterial infection in febrile young infants utilizing body temperature

Cited by 9 publications

References 21 publications

Evaluation of the accuracy of immature granulocyte percentage in predicting pediatric serious bacterial infection

Evaluation of the accuracy of immature granulocyte percentage in predicting pediatric serious bacterial infection

Metered‐dose inhaler ipratropium bromide for children with acute asthma exacerbation: A prospective, non‐randomized, observational study

Predictor of Early Administration of Antibiotics and a Volume Resuscitation for Young Infants with Septic Shock

Contact Info

Product

Resources

About