Predicting Response of Exudative Age-Related Macular Degeneration to Bevacizumab Based on Spectralis Optical Coherence Tomography

Abstract

Improvement in best-corrected visual acuity after three injections of bevacizumab can be predicted from optical coherence tomography measurements. Specifically, the authors identified subretinal fluid width and intraretinal fluid location as significant markers.

Prospective Study of Vessel Density by Optical Coherence Tomography Angiography After Intravitreal Bevacizumab in Exudative Age-Related Macular Degeneration

“…Regarding the functional aspects, in our study BCVA did not improve after the three A p value of \ 0.05 was considered to be statistically significant VD Vessel density, SCP Superficial capillary plexus, DCP deep capillary plexus, R Pearson's correlation coefficient once-monthly injections of bevacizumab and it also did not show significant correlations with CMT, probably due to changes in the outer retinal layers involved in the exudative alterations, as has also been shown by several earlier studies [35][36][37]. Our study has a number of limitations; these include the relatively small sample size of the groups of subjects and the inability of the EDI-OCT software to automatically measure the choroidal thickness.…”

Spatial Correspondence Between Intraretinal Fluid, Subretinal Fluid, and Pigment Epithelial Detachment in Neovascular Age-Related Macular Degeneration

“…Previous reports investigating quantitative biomarkers in OCT, however, have demonstrated increased significance of SRF or IRC width compared to their axial dimension, for example, height or volume. 6,7 Cases with a tilted retina possibly introduced errors concerning actual axial spatial correspondence as the A-scan direction did not correspond to the true vertical plane perpendicular to the RPE (Fig. 5a).…”

“…Whereas IRC appears to be associated with poor visual outcomes, patients affected by SRF seem to have a more favorable visual prognosis. [5][6][7][8][9] Such findings concerning structure/function correlation of imaging biomarkers may be important for personalized treatment recommendations as well as future clinical trial designs.…”

Morphological Predictive Features on Spectral-Domain Optical Coherence Tomography for Visual Outcomes in Neovascular Age-Related Macular Degeneration Treated with Ranibizumab

“…Exudative age-related macular degeneration (AMD) is a leading cause of irreversible loss of central vision in developed countries [ 1 – 3 ]. By 2040, around 288 million adults worldwide are expected to develop AMD [ 4 ].…”

“…In an effort to avoid potential complications and optimize outcomes, different regimens have been investigated [ 9 – 16 ]. Nevertheless, despite those established regimens that have been found to improve visual acuity (VA) in up to one-third of patients with subfoveal neovascular AMD [ 9 – 11 ], 10% to 15% of patients continue to lose vision and more than half of patients will demonstrate a gradual loss after an initial gain [ 3 , 9 , 11 , 17 , 18 ]. Therefore, identifying predictive factors of good and bad responders with anti-VEGF treatment allows for more accurate prediction of prognosis based on patients' baseline and imaging characteristics.…”