Predicting quality of life from symptomatology in schizophrenia at exacerbation and stabilization

Bow-Thomas, C. Christine; Velligan, Dawn I.; Miller, Alexander L.; Olsen, Jerry

doi:10.1016/s0165-1781(99)00023-2

Cited by 104 publications

(56 citation statements)

References 12 publications

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“…Todos foram seccionais, com exceção de um estudo norte-americano. 16 Os estudos tenderam a cobrir os mesmos domínios de qualidade de vida: religião, situação empregatícia, situação financeira, relacionamentos sociais e familiares, atividades cotidianas e de lazer, saúde física e mental, segurança e moradia.…”

Section: Resultsunclassified

Fatores associados à qualidade de vida de pacientes com esquizofrenia

Souza

Coutinho

2006

Rev. Bras. Psiquiatr.

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A b s t r a c t Objective: Treatment of individuals with schizophrenia in Brazil has been gradually shifting from an almost exclusively hospitalbased approach to a community-based treatment. These patients have received treatments focused less on symptoms reduction, and more on social reintegration and improvement of their life conditions. Thus, it is necessary to evaluate the quality of life of these patients living in the community. Method: A review of studies was carried out to describe the distribution of sociodemographic and clinical factors that may influence quality of life of individuals with schizophrenia. Results: Twenty-five studies were selected, most of them from European countries. The majority of these studies was developed in the 90's. Almost all studies were crosssectional, and most of them evaluated samples of individuals living in the community. Sociodemographic factors, other than monthly income, were not associated to quality of life. However, some studies found associations between quality of life and gender, age, marital status and educational level. Depressive and anxiety symptoms were related to worse quality of life in several studies. Such finding was also true for negative and positive symptoms of schizophrenia, but without an homogeneous pattern. Conclusions: Generally, studies were not consistent regarding association between sociodemographic and clinical factors and quality of life of patients with schizophrenia. These lack of homogeneity may be due to either disease-related issues or design aspects of these studies, not adequate for causal inference.

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Section: Resultsunclassified

Fatores associados à qualidade de vida de pacientes com esquizofrenia

Souza

Coutinho

2006

Rev. Bras. Psiquiatr.

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“…Meltzer et al (1990) reported that both before and after clozapine treatment, all QLS scores from their patient sample were highly intercorrelated and correlated very highly with the total QLS score. Recent investigations of the relation between symptom exacerbation and stabilization and Quality of Life (QOL) have reported QLS total scores, rather than subscale scores, in the light of each subscale's very close relation with the total score (Bow- Thomas et al, 1999). The goal of the present study was to identify the smallest subset of items from the original QLS scale that can predict the total QLS score.…”

Section: Introductionmentioning

confidence: 92%

Development of an Abbreviated Schizophrenia Quality of Life Scale Using a New Method

Bilker

Brensinger

Kurtz

et al. 2002

Neuropsychopharmacol

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The goal of the study was to develop and apply a predictive model approach to reduce the number of items collected for scales that yield a total summary score. A parsimonious subset of items from the 21-item Quality of Life Scale (QLS) that can accurately predict the total scale score was sought and evaluated in 198 patients with schizophrenia, using a statistical modeling approach. Two additional data sets were used for model validation: the subset of 101 patients used in the model construction who had the QLS administered approximately 1 year later and a new sample of 37 patients. Using only seven QLS items as predictors, the correlation was 0.9831 between the predicted and true QLS totals. Applying the model based for these seven QLS items, the correlations from the first and second validation data sets were 0.9791 and 0.9637, respectively. The study demonstrates that a small subset of items of the QLS predicts the entire 21-item scale with high accuracy. Two validation samples have confirmed the finding. This reduces the effort associated with scale administration and is likely to increase the assessment of an important functional domain. Such models can guide efforts for item reduction in other rating instruments.

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“…As the studies used the QLS which was originally designed to assess deficit symptoms of schizophrenia, it may stand to reason that fewer negative symptoms were associated with better QOL assessed by the QLS. However, some studies showed the significant associations of positive symptom and other clinical factors with the QLS (17)(18)(19)(20).…”

Section: Relation Between Clinical Symp-toms and Quality Of Lifementioning

confidence: 99%

Quality of life and its predictors in people with schizophrenia

Tomotake

2011

J. Med. Invest.

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Predicting quality of life from symptomatology in schizophrenia at exacerbation and stabilization

Cited by 104 publications

References 12 publications

Fatores associados à qualidade de vida de pacientes com esquizofrenia

Fatores associados à qualidade de vida de pacientes com esquizofrenia

Development of an Abbreviated Schizophrenia Quality of Life Scale Using a New Method

Quality of life and its predictors in people with schizophrenia

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