Predicting postoperative ischemic stroke problems
in patients following coronary bypass surgery using
neutrophil-lymphocyte ratio, platelet-lymphocyte ratio,
and red blood cell distribution width values

Tatlısuluoğlu, Derya; Tezcan, Büşra; Mungan, İbrahim; Çakirli, Yaşar Alp; Tümer, Naım Boran; Taşoğlu, İrfan

doi:10.5114/kitp.2022.117499

Cited by 3 publications

(3 citation statements)

References 41 publications

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“…24 High PLR and red cell distribution width (RDW) values have also been identified as useful and independent risk factors for predicting postoperative ischemic stroke in CPB patients. 25 In our study, LMR and NMR were able to predict the occurrence of VS 24 hours before CABG/CPB. The reduction in LMR and NMR values was dependent on decreased circulating monocytes and related to the development of VS.…”

Section: Discussionmentioning

confidence: 48%

Evolution of Hematological Parameters in Patients with Vasoplegia Following Coronary Artery Bypass Graft Surgery

Ramos,

Faé,

Hebeda

et al. 2023

ABC Heart Fail Cardiomyop

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Background: The utilization of extracorporeal circulation during a coronary artery bypass graft (CABG) surgery induces the secretion of inflammatory mediators associated with the onset of vasoplegic syndrome (VS). Blood cells contribute to the amplification of enzymatic mechanisms related to the development of VS, which is responsible for high mortality rates. Objectives: To investigate possible changes in hematological ratios to evaluate the evolution of VS in patients undergoing CABG. Methods: Analytical observational study of the retrospective cohort type, utilizing data collected from medical records in a reference cardiology hospital. Results: VS was associated with decreased monocyte rates (p = 0.02) 24 hours before the CABG, as well as elevated lymphocyte/monocyte ratio (LMR) (p = 0.01) and neutrophil/monocyte ratio (NMR) (p = 0.01) on the same period. Twenty-four hours after the procedure, increased neutrophil counts (p = 0.05) and platelet/lymphocyte ratio (PLR) (p = 0.03), as well as neutrophil/lymphocyte ratio (NLR) (p = 0.04), were associated with VS. Between 24 and 48 hours after CABG, neutrophil ratios (p = 0.01), PLR (p = 0.02), MLR (p = 0.04), and systemic inflammation response index (SIRI) (p = 0.02) were lower in patients who developed vasoplegia. Conclusion: A decreased monocyte count 24 hours before CABG was associated with the development of VS, as well as an elevated neutrophil count 24 hours after the procedure. Higher LMR and NMR 24 hours before the surgery, as well as PLR and MLR after the cardiac surgery were also associated with VS. Our data show different hematological changes at different times after CABG and highlight that new studies are essential to allow the use of hematological ratios in the monitoring of patients undergoing CABG.

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Section: Discussionmentioning

confidence: 48%

Evolution of Hematological Parameters in Patients with Vasoplegia Following Coronary Artery Bypass Graft Surgery

Ramos,

Faé,

Hebeda

et al. 2023

ABC Heart Fail Cardiomyop

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“…Red Cell Distribution Width (RDW) is a hematological parameter that is often elevated in the setting of inflammation and oxidative stress. RDW is currently associated with several diseases, including cardiovascular diseases such as stable angina [ 29 ], acute coronary syndrome [ 30 ], coronary bypass surgery [ 31 ], heart failure [ 32 ], and stroke [ 33 ]. Furthermore, albumin, with its anti-inflammatory, antioxidant, and anti-thrombotic properties, plays a crucial role in cardiovascular health [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Association of red cell distribution width/albumin ratio and in hospital mortality in patients with atrial fibrillation base on medical information mart for intensive care IV database

Pan,

Song

2024

BMC Cardiovasc Disord

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Background Atrial fibrillation (AF) is a common cardiac arrhythmia. The ratio of red cell distribution width (RDW) to albumin has been recognized as a reliable prognostic marker for poor outcomes in a variety of diseases. However, the evidence regarding the association between RDW to albumin ratio (RAR) and in hospital mortality in patients with AF admitted to the Intensive Care Unit (ICU) currently was unclear. The purpose of this study was to explore the association between RAR and in hospital mortality in patients with AF in the ICU. Methods This retrospective cohort study used data from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database for the identification of patients with atrial fibrillation (AF). The primary endpoint investigated was in-hospital mortality. Multivariable-adjusted Cox regression analysis and forest plots were utilized to evaluate the correlation between the RAR and in-hospital mortality among patients with AF admitted to ICU. Additionally, receiver operating characteristic (ROC) curves were conducted to assess and compare the predictive efficacy of RDW and the RAR. Results Our study included 4,584 patients with AF with a mean age of 75.1 ± 12.3 years, 57% of whom were male. The in-hospital mortality was 20.3%. The relationship between RAR and in-hospital mortality was linear. The Cox proportional hazard model, adjusted for potential confounders, found a high RAR independently associated with in hospital mortality. For each increase of 1 unit in RAR, there is a 12% rise in the in-hospital mortality rate (95% CI 1.06–1.19). The ROC curves revealed that the discriminatory ability of the RAR was better than that of RDW. The area under the ROC curves (AUCs) for RAR and RDW were 0.651 (95%CI: 0.631–0.671) and 0.599 (95% CI: 0.579–0.620). Conclusions RAR is independently correlated with in hospital mortality and in AF. High level of RAR is associated with increased in-hospital mortality rates.

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“…According to the literature, the neutrophil-to-lymphocyte ratio (NLR) predicts the development of postpericardiotomy syndrome (PPS) [16], atrial brillation (AF) [17,18], acute kidney injury (AKI) [19,20], saphenous vein graft failure [21,22], ischemic stroke (IS) [23] and even early postoperative mortality [24][25][26] after CABG. Therefore, NLR is a promising marker of prognosis for patients after CABG.…”

Section: Introductionmentioning

confidence: 99%

Low-grade inflammation in the prognosis of patients undergoing coronary artery bypass grafting: the value of neutrophil-to-lymphocyte ratio (NLR) and growth differentiation factor 15 (GDF15)

Garganeeva,

Kuzheleva,

Tukish

et al. 2023

Preprint

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Background Predicting major adverse cardiovascular events (MACEs) after coronary interventions is an urgent and important task. Subclinical inflammation markers are becoming increasingly investigated for this purpose. Aim To determine the role of the neutrophil-to-lymphocyte ratio (NLR) and growth differentiation factor 15 (GDF-15) in predicting MACE in patients after coronary artery bypass grafting (CABG). Methods This prospective observational study included 80 patients with coronary artery disease who underwent CABG and were followed up for at least 1 year. In a prospective follow-up, a combined endpoint (MACE) had 27.5% (a total of 22 events). Results The values of GDF-15 and NLR were comparable in groups with and without MACE. A ROC analysis showed a low AUC for NLR (AUC = 0.566 (p = 0.363)) and GDF-15 (AUC = 0.621 (p = 0.096)). The value of the product GDF-15*NLR was determined. The median was 3108.05 (2069; 4145) for patients who did not have MACE and 4108.8 (2779.4; 5890.5) for patients with MACE (p = 0.010). This association remained after the introduction of amendments to sex, age, diabetes, and left ventricular ejection fraction. Conclusions The value of the product indicators NLR and GDF-15 is associated with the development of adverse cardiovascular events in patients after CABG.

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Predicting postoperative ischemic stroke problems in patients following coronary bypass surgery using neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and red blood cell distribution width values

Cited by 3 publications

References 41 publications

Evolution of Hematological Parameters in Patients with Vasoplegia Following Coronary Artery Bypass Graft Surgery

Evolution of Hematological Parameters in Patients with Vasoplegia Following Coronary Artery Bypass Graft Surgery

Association of red cell distribution width/albumin ratio and in hospital mortality in patients with atrial fibrillation base on medical information mart for intensive care IV database

Low-grade inflammation in the prognosis of patients undergoing coronary artery bypass grafting: the value of neutrophil-to-lymphocyte ratio (NLR) and growth differentiation factor 15 (GDF15)

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