Predicting portal hypertension as assessed by acoustic radiation force impulse: correlations with the Doppler ultrasound

Abstract

Objective The purpose of this study was to assess the value of acoustic radiation force impulse (ARFI) for evaluating portal hypertension by correlating the elasticity of liver cirrhosis, as measured by ARFI, with haemodynamic indices measured by Doppler ultrasound. Methods We evaluated the data of a total of 154 prospectively enrolled patients who underwent both duplex Doppler ultrasound and ARFI imaging. The duplex Doppler ultrasound indices, including the mean portal vein velocity, splenic index (SI) and splenoportal index (SPI) were evaluated to determine the statistical correlation with shear wave velocity (SWV) of ARFI. We also analysed the differences in the correlations between the SI, SPI and SWV of the group who had varices. The correlations were assessed with Spearman9s rank correlation coefficients. Results There was an increase of SWV in parallel with the increase of the SI (r50.409, p,0.01) and SPI (r50.451, p,0.01). In the patient group who did not have varices (n574), the Doppler indices were found to be more correlated with the SWV (SI: r50.447, SPI: r50.552, p,0.01). However, the group with varices showed no correlation between the SWV and the Doppler parameters. Conclusion SWV of ARFI was well correlated statistically with Doppler parameters, but is of limited value in predicting portal hypertension directly owing to great variability of Doppler parameters. By evaluating the correlation between ARFI and Doppler ultrasound, we suggest that the SWV might be a non-invasive supplementary tool for predicting portal hypertension.

Liver and spleen elastography of dogs affected by brachycephalic obstructive airway syndrome and its correlation with clinical biomarkers

“…Twenty-two beagle dogs, from the institutional animal nutrition laboratory, were selected and comprised the mesocephalic group, according to the following defined criteria. The sample size was calculated based on previously results 64 and 15 mesocephalic and 30 brachycephalic dogs were needed to allow identification of a minimum 0.4 m/s differences on the shear wave velocity of the hepatic parenchyma, with a statistical power of 89%, using a 95% significance level. The final selection of 48 brachycephalic dogs and 22 mesocephalic allowed an increase of the statistical power to 95%.…”

Evaluation of Portal Hypertension and Varices by Acoustic Radiation Force Impulse Imaging of the Liver Compared to Transient Elastography and AST to Platelet Ratio Index

“…In our study splenomegaly as a possible sign for portal hypertension had a sensitivity for CSPH of 76 %. Furthermore, Doppler ultrasound has recently been compared with ARFI for the noninvasive diagnosis of portal hypertension and weak correlations with the portal splenic index were found [38]. However, the recent Baveno V consensus meeting on portal hypertension, the largest conference for this topic, did not report or discuss sonographic markers for the estimation of portal hypertension [3].…”

Risk Prediction of Portal Hypertension in Patients With HCV-Associated Liver Cirrhosis

“…При этом транзиентная эластография отличалась наилучшими характеристиками при использовании в качестве самостоятельного предиктора (AUC 0,883) [11]. Однако в настоящее время в литературе нет единого мнения в отношении возможности использования скорости сдвиговой волны (ARFI) для диагностики портальной гипертензии у пациентов с циррозом печени [12][13][14].…”