Predicting Optical Effects of Tear Film Break Up on Retinal Image Quality Using the Shack-Hartmann Aberrometer and Computational Optical Modeling

Himebaugh, Nikole; Thibos, Larry N.; Bradley, Arthur; Wilson, Graeme; Begley, Carolyn G.

doi:10.1007/978-1-4615-0717-8_160

Cited by 27 publications

(19 citation statements)

References 16 publications

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“…In contrast, spherical aberration, for example, depends on the 4 th power of pupil radius, which means that most of the information is outside the central 3 mm and what is measured with a small pupil is mostly noise. Another reason may be the fact that the variance in C 2 0 is not related to the inherent noise of the instrument itself, but to the dynamic characteristics of the human visual system, such as accommodation micro-fluctuations[42,43], tear film changes[44], and eye movements leading to alignment errors[32,45]. …”

Section: Discussionmentioning

confidence: 99%

Variability of wavefront aberration measurements in small pupil sizes using a clinical Shack-Hartmann aberrometer

2004

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Background: Recently, instruments for the measurement of wavefront aberration in the living human eye have been widely available for clinical applications. Despite the extensive background experience on wavefront sensing for research purposes, the information derived from such instrumentation in a clinical setting should not be considered a priori precise. We report on the variability of such an instrument at two different pupil sizes.

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Section: Discussionmentioning

confidence: 99%

Variability of wavefront aberration measurements in small pupil sizes using a clinical Shack-Hartmann aberrometer

2004

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“…Notably, sensory descriptors applied by patients with DE resemble those applied by patients with painful peripheral neuropathies [1, 5, 6]. Many individuals with ocular conditions also report itch, sometimes occurring concurrent with pain [7, 8]. …”

Section: Introductionmentioning

confidence: 99%

Neuropathic symptoms of the ocular surface: dryness, pain, and itch

Andersen

Yosipovitch

2017

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of review To describe recent findings on epidemiology, pathophysiology and management of neuropathic symptoms of the ocular surface, with a focus on potential similarities between sensations of dry eye, pain and itch. Recent findings A narrative review of the literature was undertaken. Key references from research in dry eye, neuropathic symptoms of the ocular surface, ocular pain and itch as well as general references on itch and pain neurobiology were included. Recent findings suggest aspects of DE, chronic ocular pain, and itch symptomatology is driven by neuropathic pain mechanisms involving peripheral and central sensitization processes. Summary Ocular dryness, pain, and itch are prevalent complaints with several of shared features. Multiple lines of evidence suggest that peripheral and central neuronal sensitization processes are involved in generating and maintaining ocular sensory symptoms. Research is warranted on the epidemiology of ocular sensations, molecular mechanisms involved in nociception and pruriception in the eye, electrophysiological alterations in animal models of eye conditions, and therapeutic modalities that can alleviate unpleasant ocular sensations.

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“… Components of the dacruon. Relative thicknesses of lipid sealant film and muco‐aqueous pool 8 . Diagram not to scale.…”

Section: Os Conceptsmentioning

confidence: 99%

“…The base of the MAP is anchored to the varied epithelia of its OS sac, creating a dacruon/surface complex (DSC) rather than a simple interface. By their transparency, their refracting optical characteristics and by their being morphologically anchored to the eyeball, the fluids also refine vision 5,8–10 (Fig. 6).…”

Section: Os Conceptsmentioning

confidence: 99%

Fluids of the ocular surface: concepts, functions and physics

Cher¹

2012

Clinical Exper Ophthalmology

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General adoption of the ocular surface (OS) concept has advanced the therapy of the external eye. Fresh physical findings have prompted new concepts; examples taken from each section of the text are: (i) ever-present lipid sealant bridges the palpebral fissure capping the three-dimensional 'OS' sac. The muco-aqueous pool (MAP) is thus enclosed, secluded from atmosphere, evaporation mitigated. Hence, the OS is conceptually, a compartment. The term 'dacruon' (otherwise 'tear film') has been coined for the combined fluids of the OS, viz. lipid film and MAP. (ii) Investigative techniques of physics yield data on (say) surface tension and viscosity, and on functions such as anchorage of dacruon base to the varied mucosae of the OS, lubrication, renovation of intermarginal fluid layers as the eye opens after each blink, and refinement of optics and vision by the fluids attached to the cornea. (iii) Physical events in the opening eye produce the unique 'black line' phenomenon in which capillary force induces subsurface flows into thirsty menisci, bringing about parameniscal dark grooves, pupil-ward of each meniscus. Attenuation of fluorescein in the shallowed fluid gaps behind each groove makes the dye appear unilluminated ('black lines') relative to adjacent full-thickness MAP fluid glowing under cobalt-blue illumination. Isolated from cornea by grooves and gaps, the meniscal fluid cannot pass freely over the cornea. It therefore streams through the menisci to nasolacrimal outflow.

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Predicting Optical Effects of Tear Film Break Up on Retinal Image Quality Using the Shack-Hartmann Aberrometer and Computational Optical Modeling

Cited by 27 publications

References 16 publications

Variability of wavefront aberration measurements in small pupil sizes using a clinical Shack-Hartmann aberrometer

Variability of wavefront aberration measurements in small pupil sizes using a clinical Shack-Hartmann aberrometer

Neuropathic symptoms of the ocular surface: dryness, pain, and itch

Fluids of the ocular surface: concepts, functions and physics

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