Predicting Occult Lymph Node Metastasis in Parotid Cancer

Frankenthaler, Robert A.; Byers, Robert M.; Luna, Mario A.; Callender, David L.; Wolf, Pat; Goepfert, Helmuth

doi:10.1001/archotol.1993.01880170041008

Cited by 111 publications

(74 citation statements)

References 13 publications

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“…Facial nerve palsy has been reported as a poor prognostic factor in patients with previously untreated parotid gland cancer [2,4,5] . However, in our present study, the presence of facial nerve palsy at presentation was not found to be a good prognostic factor.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Cancer of the Parotid Gland: How Well Does Salvage Surgery Work for Locoregional Failure?

Kobayashi¹,

Nakao²,

Yoshida³

et al. 2009

ORL

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Purpose: Many articles have discussed the clinical features of previously untreated parotid cancer, but the clinical characteristics and treatment of recurrent parotid cancer have not yet been fully described. Materials: We retrospectively reviewed 20 patients with recurrent parotid cancer and analyzed the therapeutic strategies and the prognostic factors. Results: Twelve patients (60%) underwent definitive surgery, including 3 who underwent skull base surgery. The 5-year overall survival (OS) and 5-year disease-free survival (DFS) in the surgery group were 66.7 and 64.1%. In the definitive surgery group, the presence of lymph node metastasis and high-grade malignant histopathology were associated with a poor prognosis (p < 0.01). On the other hand, the presence of facial palsy at presentation, the surgical margin, the time of relapse and the T stage did not affect the DFS in our series. Conclusions: The results suggest that aggressive definitive surgery may be justified for the treatment of recurrent parotid cancer. The presence of lymph node metastasis and the histopathological malignancy grade are poor prognostic factors for OS and DFS.

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Section: Discussionmentioning

confidence: 99%

Recurrent Cancer of the Parotid Gland: How Well Does Salvage Surgery Work for Locoregional Failure?

Kobayashi¹,

Nakao²,

Yoshida³

et al. 2009

ORL

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“…Armstrong et al 7 reported a 16% rate of neck involvement among 386 patients with primary parotid cancer, whereas Frankenthaler et al 8 reported a 12% incidence.…”

Section: Discussionmentioning

confidence: 99%

Incidence of cervical node involvement in metastatic cutaneous malignancy involving the parotid gland

et al. 2001

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Patients with metastatic cutaneous SCC and melanoma involving the parotid gland had a high incidence of clinical (26% and 38%, respectively) and occult neck disease (35% and 27%). Treatment of the clinically negative neck in the presence of clinical metastatic parotid cancer should be considered to reduce the likelihood of failure in cervical nodes, to define the extent of disease, and to assist with patient selection for adjuvant therapy.

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“…For the next 2 decades, the surgeons at MD Anderson subscribed to this approach to the N0 neck in patients with salivary gland tumors [18,21] . Then, in 1993, Frankenthaler et al [22] reported the results of multivariate analysis of 11 clinical and histopathologic variables in patients who had undergone elective node dissection for cancer of the parotid gland. The factors that were correlated with the presence of occult cervical lymph node metastases were facial paralysis, an older age (>54 years), a high tumor grade, perilymphatic invasion, and extraparotid tumor extension.…”

Section: The Clinically Negative Neckmentioning

confidence: 99%

“…They concluded that patients with high-grade salivary gland carcinoma and a clinically N0 neck who have undergone surgery and postoperative radiation are not likely to benefit from ND [27] . [42] 6 Lymphovascular invasion 7 Facial paralysis and perineural invasion [22,33] …”

Section: The Clinically Negative Neckmentioning

confidence: 99%

Management of Regional Metastases of Malignant Salivary Gland Neoplasms

Medina¹,

Zbären

Bradley

2016

Salivary Gland Neoplasms

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Metastases from salivary gland carcinomas to the cervical lymph nodes are relatively uncommon. However, their impact on prognosis is significant and, thus, it is important to manage them appropriately. Treatment of clinically evident metastases consists primarily of surgery, frequently followed by radiation. Management of the N0 neck, on the other hand, remains controversial. While there seems to be agreement regarding the tumor and patient factors that make it more likely for a patient to harbor subclinical metastases in the lymph nodes, some clinicians prefer to treat those patients with surgery, i.e. a neck dissection, and others prefer to use elective radiation. These different approaches and their rationale will be discussed in detail.

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Predicting Occult Lymph Node Metastasis in Parotid Cancer

Cited by 111 publications

References 13 publications

Recurrent Cancer of the Parotid Gland: How Well Does Salvage Surgery Work for Locoregional Failure?

Recurrent Cancer of the Parotid Gland: How Well Does Salvage Surgery Work for Locoregional Failure?

Incidence of cervical node involvement in metastatic cutaneous malignancy involving the parotid gland

Management of Regional Metastases of Malignant Salivary Gland Neoplasms

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