Predicting Obstructive Sleep Apnea Status With the Reflux Symptom Index in a Sleep Study Population

Teklu, Meron; Gouveia, Christopher J.; Yalamanchili, Amulya; Ghadersohi, Saied; Price, Caroline P.E.; Bové, Michiel; Attarian, Hrayr; Tan, Bruce K.

doi:10.1002/lary.28592

Cited by 18 publications

(22 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Third, the severity of LPR was evaluated through different patient‐reported outcome questionnaires including different GERD‐related 5,7,15 or laryngopharyngeal 6,14,17,21,22 symptoms. Thus, the comparison of our results with the literature remains limited regarding the use of different clinical outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…With regard to the clinical presentation of patients with OSAS and LPR, our observations supported that OSAS patients may have less severe clinical picture than LPR patients. To the best of our knowledge, only Teklu et al specifically investigated the symptom profile of LPR patients with or without OSAS, reporting that patients with OSAS had worse symptoms as measured by RSI 7 . As above‐mentioned, the inclusion of a high number of patients with GERD in the study of Tekly et al makes the comparison difficult.…”

Section: Discussionmentioning

confidence: 99%

“…The deposit of pepsin and other gastroduodenal enzymes into the respiratory tract leads to the development of an inflammatory reaction of the mucosa and respiratory symptoms. Many studies reported the coexistence between LPR and obstructive sleep apnoea syndrome (OSAS), but the exact role of reflux in the pathogenesis of OSAS is still unclear 5‐7 …”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Impedance‐pH monitoring profile of patients with reflux and obstructive sleep apnea syndrome: A controlled study

Bobin

Aurégan

Muls

et al. 2021

Clinical Otolaryngology

View full text Add to dashboard Cite

Objective To study the profile of patients with obstructive sleep apnoea syndrome (OSAS) and laryngopharyngeal reflux (LPR) at the hypopharyngeal‐oesophageal multichannel intraluminal impedance‐pH monitoring (HEMII‐pH) and to compare their reflux findings with LPR patients without OSAS. Design Prospective controlled study. Methods Patients with LPR and OSAS were prospectively recruited from August 2019 to June 2020. The profile of hypopharyngeal reflux events (HREs) of patients was studied through a breakdown of the HEMII‐pH findings over the 24 hours of testing. Reflux symptom score (RSS), and gastrointestinal and HEMII‐pH outcomes were compared between LPR patients and patients with LPR and OSAS. Multivariate analysis was used to study the relationship between reflux data and the following sleep outcomes: Apnea Hypopnea Index, Epworth Sleepiness Scale (ESS) and paradoxical sleep data. Results A total of 89 patients completed the study. There were 45 patients with LPR and 44 subjects with both OSAS and LPR. The numbers of upright and daytime HREs and the otolaryngological RSS were significantly higher in patients with LPR compared with those with OSAS and LPR. There was a significant positive association between RSS quality‐of‐life score and ESS (P = .001). The occurrence of HREs in the evening was associated with higher ESS (P = .015). Patients with OSAS, LPR and GERD had higher number of nocturnal HREs compared with those without GERD (P = .001). Conclusion The presence of OSAS in LPR patients is associated with less severe HEMII‐pH and ear, nose and throat symptoms. There may have different OSAS patient profiles according to the occurrence of GERD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Impedance‐pH monitoring profile of patients with reflux and obstructive sleep apnea syndrome: A controlled study

Bobin

Aurégan

Muls

et al. 2021

Clinical Otolaryngology

View full text Add to dashboard Cite

show abstract

“…VAS for cough [14] is used for assess the severity of cough by linear integral method. It ranges from 0 to 10.…”

Section: Visual Analogue Scale (Vas)mentioning

confidence: 99%

“…Cough symptom score Daytime and nighttime cough symptom was assessed using Chinese version of cough symptom score according to the 2015 guideline for the diagnosis and treatment of cough in China [14] . This scale is divided into 2 parts, daytime and nighttime cough symptom scores.…”

Section: Visual Analogue Scale (Vas)mentioning

confidence: 99%

Effect of Continuous Positive Airway Pressure on Chronic Cough in Obstructive Sleep Apnea Concomitant Gastroesophageal Reflux Patients: A Retrospective Observational Study

Meng

et al. 2021

Preprint

View full text Add to dashboard Cite

Background:Chronic cough is common in obstructive sleep apnea. The aetiology of chronic cough in obstructive sleep apnea patients could be multifactorial. Several studies have reported high incidence rates of gastroesophageal reflux in obstructive sleep apnea patients, and gastroesophageal reflux may be one of causes of chronic cough in OSA patients. This study aimed to investigate the effect of continuous positive airway pressure on chronic cough in obstructive sleep apnea concomitant gastroesophageal reflux patients.Methods: Obstructive sleep apnea concomitant gastroesophageal reflux patients who also suffered chronic cough were enrolled. Patients who accepted continuous positive airway pressure as treatment group, and the patients who accepted general treatment (diet control, moderate exercise, sleeping on your side, limiting alcohol consumption and proton pump inhibitor±mosapride) as control group. Effects of different treatment modalities on chronic cough were assessed, and the correlation between chronic cough, obstructive sleep apnea and gastroesophageal reflux were performed by Pearson correlation analyses. Results: All Patients had poor sleep quality, severe daytime sleepiness, moderate-severe sleep apnea, significant weak acid reflux and moderate coughing events at the baseline. Compared with the baseline, PSQI and ESS score were improved in treatment group after 1 week’s treatment, the improvement became stronger with duration of therapy (P＜0.05). GERD-Q score, VAS score, daytime and night cough symptom score were all significantly improved in these two groups after treatment (P＜0.05), while this improvement was more pronounced in the treatment group ( P＜0.05). There were significant correlation between AHI and VAS score (r=0.612, P＜0.05), weak acid reflux and VAS score (r=0.429, P＜0.05), weak acid reflux and AHI (r=0.366, P＜0.05). Conclusion: The improvement in chronic cough and gastroesophageal reflux was due to the resolution of obstructive sleep apnea. AHI and weak acid reflux may be critical factors affecting the therapeutic effect of chronic cough in obstructive sleep apnea concomitant gastroesophageal reflux patients.

show abstract

International Consensus Statement on Obstructive Sleep Apnea

Chang

Goldberg

Alt

et al. 2023

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background: Evaluation and interpretation of the literature on obstructive sleep apnea (OSA) allows for consolidation and determination of the key factors important for clinical management of the adult OSA patient. Toward this goal, an international collaborative of multidisciplinary experts in sleep apnea evaluation and treatment have produced the International Consensus statement on Obstructive Sleep Apnea (ICS:OSA). Methods: Using previously defined methodology, focal topics in OSA were assigned as literature review (LR), evidence-based review (EBR), or evidencebased review with recommendations (EBR-R) formats. Each topic incorporated the available and relevant evidence which was summarized and graded on study quality. Each topic and section underwent iterative review and the ICS:OSA was created and reviewed by all authors for consensus. Results: The ICS:OSA addresses OSA syndrome definitions, pathophysiology, epidemiology, risk factors for disease, screening methods, diagnostic testing types, multiple treatment modalities, and effects of OSA treatment on multiple OSA-associated comorbidities. Specific focus on outcomes with positive airway pressure (PAP) and surgical treatments were evaluated. Conclusion:This review of the literature consolidates the available knowledge and identifies the limitations of the current evidence on OSA. This effort aims to create a resource for OSA evidence-based practice and identify future research needs. Knowledge gaps and research opportunities include improving the metrics of OSA disease, determining the optimal OSA screening paradigms, developing strategies for PAP adherence and longitudinal care, enhancing selection of PAP alternatives and surgery, understanding health risk outcomes, and translating evidence into individualized approaches to therapy.

show abstract

Predicting Obstructive Sleep Apnea Status With the Reflux Symptom Index in a Sleep Study Population

Cited by 18 publications

References 55 publications

Impedance‐pH monitoring profile of patients with reflux and obstructive sleep apnea syndrome: A controlled study

Impedance‐pH monitoring profile of patients with reflux and obstructive sleep apnea syndrome: A controlled study

Effect of Continuous Positive Airway Pressure on Chronic Cough in Obstructive Sleep Apnea Concomitant Gastroesophageal Reflux Patients: A Retrospective Observational Study

International Consensus Statement on Obstructive Sleep Apnea

Contact Info

Product

Resources

About