Predicting nuclear G-quadruplex RNA-binding proteins with roles in transcription and phase separation
Johanna Luige,
Alexandros Armaos,
Gian Gaetano Tartaglia
et al.
Abstract:RNA-binding proteins are central for many biological processes and their characterization has demonstrated a broad range of functions as well as a wide spectrum of target structures. RNA G-quadruplexes are important regulatory elements occurring in both coding and non-coding transcripts, yet our knowledge of their structure-based interactions is at present limited. Here, using theoretical predictions and experimental approaches, we show that many chromatin-binding proteins bind to RNA G-quadruplexes, and we cl… Show more
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